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15 articles for “AKT”
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Computational Investigation of Phytochemicals Targeting AKT1 for Major Depressive Disorder: A Molecular Docking and ADMET Study
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric condition affecting approximately 280 million individuals worldwide, with women exhibiting a 50% higher likelihood of diagnosis than men. Despite significant advancements in treatment, MDD remains a chronic and relapsing disorder, necessitating the exploration of novel therapeutic interventions. This study focuses on the AKT1 gene, a key player in neuropsychiatric disorders, and investigates its interactions with natural phytochemicals as potential alternatives to conventional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Quality Appraisal for the Ornamental Bird, Fish, Dog, and Cat Foods Available in Bangladesh
Abstract: The study aimed to assess if the chemical composition of different avian, aquatic, dog, and cat foods commonly available in Chattogram, Bangladesh adheres to the recommended standards. Food samples were collected and subjected to proximate analysis for the dry matter (DM), crude protein (CP), crude fibre (CF), ether extract (EE), nitrogen free extract (NFE), and total ash (TA). The plant seeds used for ornamental birds exhibited substantial variability in terms …
Published in Research and Reviews : Journal of Veterinary Science and Technology Read article
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Network Pharmacology and Molecular Docking Approach to Reveal the Underlying Mechanisms of Isorhamnetin in the Treatment of Lymphangitis Carcinomatosis
Abstract: Objective: Lymphangitic carcinomatosis (LC) is a tumor that spreads through lung lymphatics and is most commonly seen secondary to adenocarcinoma. In the majority of cases, LC is a result of tumor cells spreading through the lymphatic system. However, approximately 20% of LC cases can be attributed to lymphangitis caused by tumors obstructing lymphatic drainage. This blockage commonly occurs near the lung hilum, where a centrally located mass can cause inflammation …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 1, 2023 · pp. 28–45 Read article
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Integrating Network Pharmacology and Molecular Docking to Investigate Boerhavia diffusa for Pancreatic Cancer Treatment
Abstract: Objective: In this study, network pharmacology was applied to determine the therapeutic effects of the bioactive compounds of Boerhavia diffusa. Network pharmacology can unearth the underlying mechanisms between drugs and the disease targets and aids in the discovery of novel medications for complex conditions such as cancer. Methods: To predict the molecular mechanisms of action of Boerhavia diffusa in the treatment of was screened using the GeneCards database. The Venn …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 29–49 Read article
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The Impact of Climate Change on Jute Production in Gaibandha District, Bangladesh
Abstract: Jute plays a crucial role in Bangladesh’s agricultural economy, especially in Gaibandha District, where it is a key crop for rural livelihoods. However, climate change, characterized by rising temperatures and unpredictable rainfall, poses significant threats to jute production. While numerous studies have explored the broader impact of climate change on agriculture, there is a gap in understanding how localized climate conditions specifically affect jute farming in Gaibandha, with many existing …
Published in International Journal of Climate Conditions · Vol. 2, Issue 1, 2025 · pp. 1–17 Read article
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Modeling Dispersed Count Data: Evaluating the Conway–Maxwell–Poisson Regression with COVID-19 Mortality Data
Abstract: Count data are prevalent in diverse fields such as biology, healthcare, psychology, and marketing, characterized by non-negativity and inherent heteroskedasticity, often exhibiting overdispersion or underdispersion. Traditional Poisson regression, which assumes equal mean and variance, is inadequate for such dispersed data. To address this, various generalized linear models (GLMs) and their extensions, including negative binomial (NB) and Conway–Maxwell–Poisson (CMP) regressions, are utilized. This study evaluates the performance of CMP regression compared …
Published in Research & Reviews : Journal of Statistics · Vol. 13, Issue 3, 2024 · pp. 18–26 Read article
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Comparative Effectiveness of Various Fungicides in Managing Mustard Clubroot Disease Caused by Plasmodiophora Brassicae
Abstract: The experiment was accomplished to find out which fungicide or fungicides work best against clubroot disease and how well they protect mustard plants. It also looked at how these fungicides affect the yield and other important growth factors of mustard. The study took place in the research field and lab of the Plant Pathology Division at the Regional Agricultural Research Station (RARS), Bangladesh Agricultural Research Institute (BARI), located in Jamalpur-2000, …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 15, Issue 1, 2026 · pp. 1–11 Read article
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Efficacy of New Fungicides in Controlling Powdery Mildew of Sweet Gourd
Abstract: This experiment was conducted at the Plant Pathology Division, Regional Agricultural Research Station (RARS), Jamalpur, Bangladesh during 2025 of Rabi & Kharif-1 seasons to find out the effectiveness of new fungicides against Powdery mildew disease of sweet gourd. Twenty (20) new fungicides viz. Acrozet 50 WP, Qingdao GBW, Hea 10 FC, Top star 32.5 SC, Nila 80 WP, Soazeb 72 WP, Safezeb 80 WP, Canvas 32.5 SC, Pyzim 50 WP, …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 14, Issue 3, 2025 · pp. 134–142 Read article
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Screening of Mustard Varieties and Lines against Clubroot and Alternaria Leaf Spot Diseases
Abstract: The experiment was conducted to find out the resistant varieties/lines against clubroot and Alternaria leaf spot diseases of mustard at the Plant Pathology Division, RARS Jamalpur, Bangladesh during the Rabi season of 2024-2025 with sixty-two (62) varieties and lines of Mustard collected from Oilseed Research Centre (ORC) and Plant Genetic Resources Centre (PGRC), Joydebpur, Gazipur-1701, Bangladesh. To screen for clubroot and Alternaria leaf spot diseases and to evaluate yield and …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 14, Issue 3, 2025 · pp. 97–106 Read article
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Assessing the Effectiveness of New Fungicides Against Potato Late Blight Disease (Phytophthora Infestans)
Abstract: An experiment was conducted in the field of the Plant Pathology Division, Regional Agricultural Research Station (RARS), Bangladesh Agricultural Research Institute (BARI), Jamalpur, Bangladesh during the rabi season of 2024–2025 to determine the appropriate chemical fungicide for controlling late blight disease of potato. The evaluation included twenty-five new fungicides approved by the Pesticide Technical Advisory Committee (PTAC), Bangladesh, along with a standard control (Ridomil Gold MZ 68 WG) and an …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 15, Issue 1, 2026 · pp. 28–38 Read article
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Evaluation of New Fungicides for the Management of Mango Anthracnose Disease Caused by Colletotrichum Gloeosporioides
Abstract: A field experiment was conducted at the field of Plant Pathology Division, Regional Agricultural Research Station (RARS), Bangladesh Agricultural Research Institute (BARI), Jamalpur-2000, Bangladesh during February to July 2024 to assessment the efficacy/effectiveness of thirty-five (35) new fungicides received from Pesticide Technical Advisory Committee (PTAC), Bangladesh with control treatment against anthracnose disease of mango. Most of the fungicides under inspection were able to control the disease successfully. This study suggests …
Published in International Journal of Trends in Horticulture · Vol. 3, Issue 1, 2026 · pp. 1–16 Read article
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Role of PI3K/AKT/mTOR Signaling Pathways in Breast Cancer
Abstract: Abstract: Breast cancer is among the most commonly diagnosed cancers and remains a leading cause of mortality among women globally. Although early detection and interventions aimed at curtailing tumor progression have significantly improved breast cancer survival rates, there is an ongoing demand for more potent systemic therapies to effectively prevent metastasis. A central pathway frequently associated with the growth, survival, and motility of breast cancer cells is the PI3K/AKT/mTOR signaling …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 23–34 Read article
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In Silico Prediction of Multitarget Mechanism of Quinoline and Its Analogs on Phosphoinositide-3-Kinase Pathway Proteins
Abstract: Objective: Phosphoinositide 3-kinases (PI3Ks), the target of rapamycin (PI3K/Akt/mTOR, PAM), are a family of enzymes that play a role in the growth, proliferation, differentiation, motility, survival, and intracellular trafficking of cells, all of which are essential for healthy cellular function and are also connected to cancer. In this study, quinoline and its derivatives were employed to analyze its inhibition activity on the phosphoinositide-3-kinase pathway. Methods: In this work, eight phytocompounds …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 57–76 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia
Abstract: Objective: Acute myeloid leukemia (AML) is an apoptotic condition in the hematopoietic system induced by the differentiation and maturation of stem cells into erythrocytes, and leukemic cell proliferation is suppressed as the PI3K-Akt-mTOR pathway is pharmacologically targeted with certain inhibitors. As a result, in silico molecular docking of compounds against AML receptors, CTMP, was used in computational research on Hemidesmus indicus to uncover therapeutic phytochemicals for AML. Thus, this study …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 38–53 Read article