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171 articles for “drug discovery and development”
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An Introduction of Glycoside- “It’s Classification, Biogenesis, Identification, Extraction and Healthful Uses”
Abstract: A glycoside is a molecule within which a sugar is absolute to another functional group through a glycoside bond. Glycosides play various vital roles in living organisms. Several plants store chemicals within the kind of inactive glycosides. It may be activated as thanks to that sugar half broken off then its creating the chemical offered to be used. In common terms, an organic compound is any molecule within which a …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 3, 2015 · pp. 4–11 Read article
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A Novel Analytical Method for the Simultaneous Estimation of Remogliflozin and Metformin Hydrochloride
Abstract: Specific and novel strategy has been improved for assessment of Remogliflozin and Metformin hydrochloride in mass and plan and cleaning tests by UPLC-PDA. The scientific method was the phosphate Buffer (pH: 4.5): Acetonitrile, (60:40%, v/v) utilizing the spherisorb C18, 5 µm, 4.6 mm×150 mm insightful segment with investigation season of 5 min. The progression of versatile stage through section was 1.0 ml/min. The test volume was 10 µl. The discovery …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 7, Issue 3, 2020 · pp. 1–15 Read article
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Nanotechnology and its Potential in the Future
Abstract: Nanotechnology is the study of extremely small structures. The prefix “Nano” is derived from the Greek word “nanos” meaning ‘DWARF’ (Small). The beauty of nanotechnology is its ability to make things smaller, so they have more impact on our lives. Nanotechnology deals with materials in the size of 0.1 to 100 nm. One nanometer is one billionth of a meter (10–9 m or 10–7 cm), about 100 thousand times smaller …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 12, Issue 1, 2022 · pp. 17–27 Read article
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Microemulsion: Novel Carrier for Drug Delivery
Abstract: Since the discovery of much novel formulation belongs to the lipid based drug delivery system, the handicapped property of drug molecule reverted to the fittest, doable and easily delivered with strategies of improving bioavailability and depleting dose of the same. Microemulsion system is clear, stable, isotropic mixture of oil, water and Smix (Surfactant and co-surfactant mixture), frequently in combination with a co-solvents. To date microemulsions have been shown to be …
Published in Trends in Drug Delivery · Vol. 3, Issue 1, 2016 · pp. 1–18 Read article
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Recent Advancements and Comprehensive Review on Hyphenated Techniques
Abstract: Hyphenated techniques represent a powerful class of analytical methods that combine two or more established techniques – typically a separation method with a spectroscopic detection technique – to achieve enhanced analytical performance. First introduced by Hirschfeld in 1980, the term “hyphenation” refers to the online coupling of such methods, enabling more precise, sensitive, and comprehensive analysis of complex samples. These techniques exploit the strengths of individual methods while overcoming their …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 37–50 Read article
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Drug Screening Using Stem Cell Technology
Abstract: Stem cell technology in drug screening has transformed the research and development sector of pharmaceuticals. Although stem cells imitate their human counterparts in terms of both safety and potential, it is a new paradigm for mimicking diseases of humans and scale measuring for toxicity. These tissues will, therefore, be more predictive of what will happen in humans during clinical situations, compared to conventional cell lines or animal models, since they …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 42–51 Read article
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Screening of Newer Phytoconstituents on Novel Enzymes for their Biological Activity
Abstract: Background: Hyperlipidemia and gout are prevalent metabolic disorders significantly impacting global health. The xanthine oxidase and HMG-CoA reductase pathways play pivotal roles in the pathophysiology of these conditions. This study explores the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors for these enzymatic targets, offering insights into innovative therapeutic strategies. Aim: To evaluate the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors of xanthine oxidase and HMG-CoA reductase …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 81–86 Read article
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Advancements in Quantum Computing: Challenges and Prospects
Abstract: Quantum computing has emerged as a promising field with the potential to revolutionize computation by harnessing the principles of quantum mechanics. In recent years, significant advancements have been made in the development of quantum computers, quantum algorithms, and quantum error correction. However, several challenges still need to be overcome before quantum computing can become a practical and scalable technology.This review article provides a comprehensive overview of the recent advancements in …
Published in Research & Reviews : Journal of Physics · Vol. 12, Issue 1, 2023 · pp. 22–25 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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Synthesis and Evaluation of New Coumarin Derivatives for Inflammatory Bowel Disease Against DSS-Induced Acute Ulcerative Colitis Mice Model
Abstract: Objective: The discovery of the now numerous mouse models of intestinal inflammation has increased our understanding of the intestinal inflammation that occurs in inflammatory bowel disorders (IBD). This study aimed to investigate the use of a standardized animal model subjected to coumarin derivative treatment, and the action of synthesized molecule administration of dextran sodium sulphate (DSS)- induced colitis in experimental mice. Materials and Methods: We generated a variety of unique …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 14, Issue 4, 2023 Read article
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2D QSAR Studies on Some Novel 17a-aza-D-Homo Steroids as 5α-Reductase Inhibitors
Abstract: The major circulating hormone dihydrotestosterone (DHT) is responsible for the development and progression of benign prostate hyperplasia (BPH). Dihydrotestosterone (DHT) is by produced by NADPH dependent reduction of testosterone (T) under the catalytic effect of the enzyme 5α-reductase (5 alpha R). Inhibition of 5α-reductase enzyme is the novel approach for treatment of BPH. Present work describes relationship between the 5α-reductase inhibitory activity for structurally related amides and esters of 17a-Aza-D-Homo-17-one …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 1–14 Read article