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284 articles for “tolerance”
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Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
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Integrating Biotechnology, Physiology, and Agroecological Practices for Sustainable Crop Production and Protection
Abstract: Global agriculture is currently confronting a wide range of complex challenges, including a rapidly growing population, climate change, increasing pest and disease pressures, soil degradation, water scarcity, and the urgent need for sustainable intensification of crop production. Addressing these issues requires integrated strategies that combine crop improvement (through modern breeding and biotechnology), precision agronomic practices related to soil, irrigation, and nutrition, as well as advancements in plant physiology, molecular biology, …
Published in International Journal of Trends in Horticulture · Vol. 2, Issue 2, 2025 · pp. 1–6 Read article
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The Role of Symmetry in Topological Insulators and Superconductors
Abstract: Topological insulators and superconductors constitute a class of quantum materials characterized by insulating bulks and symmetry-protected conducting boundaries. Symmetry principles, notably time-reversal (TRS), particle-hole (PHS), and chiral symmetry, play a fundamental role in determining the topological phases and their classification within the Altland-Zirnbauer scheme. TRS protects gapless surface states in topological insulators, while PHS stabilizes Majorana modes in topological superconductors. Symmetry-protected topology extends this framework by considering partial symmetry breaking, …
Published in Emerging Trends in Symmetry · Vol. 1, Issue 2, 2025 · pp. 01–05 Read article
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Performance Analysis of GLARE Composites in Aerospace Engineering
Abstract: The fuel consumption of an aircraft is largely governed by its payload, which emphasizes the continuous demand for advanced lightweight structural materials to enhance the lift-to-weight ratio and improve overall fuel efficiency. Fiber Metal Laminates (FMLs) have emerged as a novel class of hybrid materials that combine alternating layers of thin metals with fiber-reinforced polymer composites, thereby offering mechanical properties superior to those of the individual constituents. Among the different …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 771–779 Read article
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Assessment of Matrix Cracking and Fiber Breakage in Hybrid Composite Materials.
Abstract: Hybrid composite materials, combining two or more distinct fiber or matrix constituents, have emerged as advanced structural solutions for aerospace, automotive, marine, and civil engineering applications. However, their complex microstructure makes them susceptible to multiple interacting damage mechanisms, particularly matrix cracking and fiber breakage. This study provides a comprehensive assessment of these damage modes, emphasizing their initiation, evolution, and combined effects on the mechanical integrity of hybrid composites. Matrix cracking …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 2, 2025 · pp. 1–5 Read article
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Terminalia arjuna: The Medicinal Tree
Abstract: Over 85% of the medications used in both conventional and alternative medical systems come from plant sources. The stem bark of Terminalia arjuna (T. arjuna) is rich in minerals, flavonoids, and glycosides. T. arjuna bark is unique because flavonoids have been shown to have anti-inflammatory, lipid-lowering, and antioxidant properties, and glycosides are cardiotonic. A variety of topics related to its ethnomedical, phytochemical, pharmacological, and clinical significance to different medical conditions …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 3, 2025 · pp. 27–34 Read article
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Thermal Stability and Impact Performance of Basalt–Carbon Hybrid Laminates in Polyimide–Phenolic Matrices
Abstract: The impact resistance and thermal stability of the advanced polymer composites are properties that are necessary for the components that are subjected to dynamic conditions, which show the overall reliability and service performance of the laminates applied in automotive structures, protective casings, etc. These properties prevent premature softening or breakdown during long-term exposure to heat. Impact resistance and thermal stability of composite laminates are studied based on fiber orientation and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 247–260 Read article
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Experimental Analysis of Glass Fiber Composite on Low Velocity Impacts
Abstract: This research specifically deals with determining the retained tensile strength after loading Glass Fiber Reinforced Polymer (GFRP) composites following low-velocity impact. The purpose is to determine the degree to which these impacts affect the structural performance and mechanical integrity of GFRP materials. Experimental tests were conducted on glass fiber composite specimens in order to observe variation in tensile strength upon impact. The results indicated significant tensile strength reduction in impact …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 789–796 Read article
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Cancer Chemotherapy-Induced Cachexia: Bridging Mechanisms, Management, and Future Therapies
Abstract: Involuntary weight loss, skeletal muscle atrophy, adipose tissue depletion, anorexia, and systemic inflammation are all symptoms of chemotherapy-induced cachexia, a complex illness. Although it is common, it remains poorly understood and is often referred to as an "orphan disease." This study covers the epidemiology, pathophysiology, clinical symptoms, diagnosis, treatment, and emerging treatment options for chemotherapy-induced cachexia. To comprehend the causes, clinical results, and therapeutic approaches, a literature-based synthesis of recent …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 17–26 Read article
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Feasibility Analysis of Wireless Power Transfer Technologies for Electric Vehicle Charging Applications
Abstract: The rapid pace of electric vehicles (EVs) has heightened the pressure on the need to have flexible, safe, and efficient infrastructures in addition to the plug-in infrastructures. The Wireless Power Transfer (WPT) has become a promising alternative that provides automated charging, better convenience, and a possible integration into the smart highways and urban environment. The present paper provides a feasibility study of the key WPT technologies in EV charging namely, …
Published in Journal of Automobile Engineering and Applications · Vol. 13, Issue 1, 2026 · pp. 29–40 Read article
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ML-Driven Optimization Framework for the Analysis, Design, and Development of Efficient Wireless Power Transfer Systems for EV Charging
Abstract: The fast uptake of electric vehicles (EVs) has heightened the necessity of effective, dependable and convenient charging systems. The Wireless Power Transfer (WPT) systems can be taken as a potential solution as they allow charging cells without contact, without any risks, and without any overcrowding; the efficiency of the system is strongly influenced by the alignment of coils, the fluctuations of air-gaps, the conditions of the loads, and geometrical arrangements …
Published in International Journal of Manufacturing and Production Engineering · Vol. 4, Issue 1, 2026 · pp. 1–9 Read article
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Electromagnetic and Dielectric Performance of Polymer–Ceramic Composite Substrates for Fractal-Based IoT-Antenna Fabrication
Abstract: Polymer–ceramic composite substrates play a crucial role in determining the electromagnetic performance, mechanical stability, and thermal reliability of radio-frequency devices. In this work, a polymer-based composite substrate is systematically investigated for its suitability in compact IoT and RFID antenna applications. A fractal-structured antenna is employed as a functional test platform to evaluate the dielectric behavior, impedance characteristics, and radiation efficiency of the composite substrate. Novelty of the proposed reader antenna …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1518–1534 Read article
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Bioinspired Nanocomposite Bone Pins: Fabrication, Evaluation, and Suitability for Orthopedic Implant Applications
Abstract: Bone tissue engineering (BTE) requires scaffolds that mimic bone’s mineral–organic composition, offering mechanical strength, bioactivity, and degradation rates compatible with regeneration. Conventional metallic implants face corrosion and toxic ion release risks, while ceramics like hydroxyapatite (HAp) are bioactive but brittle. This study reports a multifunctional hybrid scaffold combining HAp for osteoconductivity; polycaprolactone (PCL) and collagen for flexibility and biocompatibility with sodium citrate for nanoparticle dispersion, ferrocene (Fc) for catalytic bioactivity; …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 526–540 Read article
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Quorum Sensing and Biofilm Dynamics in Pathogens: An Evolving Frontier in Infectious Disease
Abstract: Bacterial and fungal pathogens rarely act as solitary invaders. Instead, they engage in sophisticated chemical communication known as quorum sensing (QS) to coordinate population-wide behaviours and construct structured, multicellular biofilm communities. These biofilms, composed of extracellular polymeric substances, not only facilitate microbial persistence on biotic and abiotic surfaces but also confer remarkable protection against host immune defenses and antimicrobial therapies. QS systems act as central regulators of biofilm dynamics, orchestrating …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 18–23 Read article
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Multi-Layer Aluminum–Polymer Hybrid Structures for Improved Automotive Impact Performance
Abstract: Layered metal–polymer hybrid laminates have emerged as promising candidates for lightweight automotive structures requiring high impact resistance and structural reliability. In this study, aluminum/glass–epoxy hybrid laminates were fabricated using a symmetric stacking sequence through hot compression molding to evaluate their mechanical and energy absorption performance. Density analysis revealed an average measured density of 2.34 g/cm³, closely matching the theoretical value of 2.36 g/cm³, with a deviation of approximately 1.02%, indicating …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 42–53 Read article
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Improving Black Cotton Soil with Sodium Hydroxide and Fly Ash: An Assessment of Optimum Moisture Content, Dry Density, and California Bearing Ratio
Abstract: This study investigates the stabilization of Black Cotton Soil (BCS), an expansive clayey soil primarily composed of montmorillonite minerals, using sodium hydroxide (NaOH) and fly ash. Due to its high plasticity and significant volume changes with moisture, BCS is challenging for construction purposes. Adding NaOH and fly ash can potentially improve the soil's moisture tolerance, compressibility, and reduce its plasticity, making it more suitable for structural applications. The research evaluates …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 192–201 Read article
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High-Velocity Impact Response of CFRP and Hybrid Composites: A Comprehensive Review on Ballistic Resistance and Damage Mechanisms
Abstract: This review consolidates recent advances in the study of high-velocity impact response of carbon fiber reinforced polymer and hybrid composites. Carbon fiber reinforced polymer composites are widely applied in aerospace, automotive, and defense due to their high strength-to-weight ratio, stiffness, and durability. However, their susceptibility to impact damage such as delamination, matrix cracking, and fiber breakage limits their performance under dynamic loading. To overcome these challenges, researchers have explored reinforcement …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 100–122 Read article
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Integration of Modular Multilevel Converter Topology in the Design and Control of Hybrid Electric Vehicles
Abstract: A back-to-back modular multilevel converter (BMMC) based plug-in hybrid electric vehicle power conversion system is proposed to solve the problems of traditional MMC-EV. The local AC harmonics generated by the operation of MMC-EV accelerate the battery degradation and reduce the battery life. Currently, electric vehicles are in great demand due to the rising oil prices and environmental pollution concerns. Since the backbone of electric vehicles is the energy storage system, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1195–1205 Read article
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GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
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Damage Evolution and Delamination Resistance in Polymer Matrix Functionally Graded Laminates
Abstract: Functionally graded laminates (FGLs) in polymer-matrix systems represent a promising pathway to enhance damage tolerance and delay delamination in advanced structural composites. In this study, we explore the mechanisms of damage initiation, propagation, and delamination resistance in polymer matrix functionally graded laminates (PM-FGLs) through a combined experimental–computational approach. Laminates with linear, exponential, and bio-inspired gradation profiles were fabricated using vacuum-assisted resin transfer molding (VARTM) and additive manufacturing techniques. Comprehensive mechanical …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 321–337 Read article