Search
153 articles for “metabolite”
-
In Vitro and In Vivo Screening on Anti-diabetic Properties of Hemidesmus indicus in Alloxan Induced Diabetic Rat Model
Abstract: The aim of the present study is to investigate the anti-diabetic potential of Hemidesmus indicus Linn. R. root extract in Alloxan induced diabetic rat. In phytochemical analysis most of the metabolites in the root extract was noticed such as Anthraquinones, flavonoids, phenols, steroids and proteins. In vitro alpha amylase inhibition assay shows significant percentage of inhibition (14.58%, 22.92%, and 45.83%) with increasing concentration of extracts (0.01 ml, 0.1 ml and …
Published in Research & Reviews : Journal of Herbal Science · Vol. 8, Issue 2, 2019 · pp. 1–6 Read article
-
Assessment of Antioxidant and Antimicrobial (Therapeutic) Potentials of Some Medicinally Important Beverages
Abstract: Herbal tea is widely used for its medicinal properties. Here the Tulsi ginger tea and Tulsi lemongrass tea were taken for antimicrobial and antioxidant assays to compare their therapeutic potentials. Different solvents viz water and Methnol: HCl (99:1) were taken to compare the antioxidant and antimicrobial activities. At the same time Ashwagandha and Arjuna Churna was taken to assess their therapeutic/medicinal values by assessing antioxidant and antimicrobial potential against two …
Published in Research & Reviews : Journal of Herbal Science · Vol. 10, Issue 2, 2021 · pp. 8–13 Read article
-
Therapeutic Medicinal Plants: Traditional uses of the Himalayan Cherry Prinsepia utilis used by Traditional Healers of the North Western Himalayan Region
Abstract: The medicinal plants of the northwestern Himalayas are noted for their unparalleled biodiversity and important secondary metabolites that are peculiar to this dynamic geoclimatic zone. The scientific documentation of the richness, distribution, and conventional applications of medicinal flora in this Mountainous region can be crucial in the conservation and sustainable use of these valuable plant resources. These medicinal plants have been used for their therapeutic properties since ancient times. The …
Published in Research & Reviews : Journal of Herbal Science · Vol. 12, Issue 3, 2023 · pp. 13–20 Read article
-
Development of A Rapid Microtiterplate Based Colorimetric Method for Estimation of Non-esterified Fatty Acids in Bovine Plasma
Abstract: Non-esterified fatty acid (NEFA) is one of the most important blood metabolites contributing significantly during body growth, cyclicity, pregnancy and lactation, and it plays more vital role particularly during transition phase of the biological processes like pregnancy to lactation transition period. Determination of blood concentrations of NEFA is, therefore, important. The measurement technique or assay for measurement of blood NEFA should be simple, reliable, accurate, rapid and cheap. Here, the …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 4, Issue 3, 2015 · pp. 29–34 Read article
-
Modulation of Receptor Proteins: A Recent Paradigm in Drug Discovery and Target
Abstract: The main aim in drug discovery is to design different ligands those work on specific drug targets. However, various effective drugs work through the modulation of many proteins than single target. Advancement in system biology are establishing a phenotypic strength and a network structure, which suggests that, the excellent selective compounds may be performed less than desired clinical efficacy in comparison to multi-target drugs. In this new appreciation of the …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 14–24 Read article
-
Assessment and In Vitro Studies of Potent Amylase Inhibitor from Different Plant Species
Abstract: Flavonoids are naturally occurring compounds widely distributed in plants, which have hypoglycemic potential. Amylase inhibitors belong to flavonoids that block amylases which are involved in hydrolyzing the carbohydrates to yield low molecular weight dextrin and sugars. Inhibition of α-amylase along with α-glucosidase can significantly reduce the post-prandial increase of blood glucose and can be an important strategy in the control of blood glucose level in the type-2 diabetic patients. In …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 1–6 Read article
-
Exploring Molecular Structural Requirement of Acetylcholinesterase Inhibitors Using Molecular Docking Study
Abstract: To explore the molecular structure requirement of acetyl-cholinesterase inhibitors, we used some flavonoid derivatives and calculated its binding interaction with acetylcholinesterase enzyme using 1EVE PDB. Flavonoids are one of the largest class and plant secondary metabolites known to have variety of biological activity for human wellbeing. Also reported its acetylcholinesterase inhibitory potency by various researchers. To know the properties and selection of flavonoids, we were used databases through Google Scholar, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 20–34 Read article
-
Quantitative Estimation of the Total Flavonoid Contents of Anogeissus pendula Stem
Abstract: Flavonoids are the typical secondary metabolites contents which are very useful in the plants as well as for human beings. They are one of the sources of several kinds of biological activity in the stem as well as in other part of the plants. These flavonoids are the typical antioxidants as well as they are used in inflammation; they are the typical antimicrobial, they have well distribution in the whole …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 55–57 Read article
-
Preliminary Phytochemical Investigation of the Leaves and Stem of the Prosopis cineraria (L.) Druce
Abstract: The trees are the greatest gift to the mankind; the civilization on this planet depends on the successful utilization of the plants and the animals for the various purposes. Early man depends on the nature’s mercy and they hunted the animal for the hunger but as the human started the domestication, they use the trees and they observed the natures for the several purposes. The trees are the reservoirs of …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 39–43 Read article
-
Extraction and Purification of Total Phenolic Content from seeds of Dimocarpus longan fruit
Abstract: Total phenolic compounds are belonging to secondary metabolites and played an antioxidant and anti-cancer activity. In the Soxhlet extraction process, the extraction of total phenolic content concentration was 8.6 µg/ml obtained from seeds of longan fruit at 5 hr. This extract was drawn in to the column chromatography and its concentration was increased to 9.2 µg/ml. The purity of phenolic content was improved by column chromatography at 40 min. Keywords: …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 4, Issue 3, 2017 · pp. 19–21 Read article
-
Pharmacognostic and Phytochemical Investigation of Pods of Albizia lebbeck (L.) Benth.
Abstract: Albizialebbeck (L.) Benth. is well known as the medicinal plant in the Ayuerveda, Siddha and Unani system of medicines. The drug isolated from different parts of this plant is used in different sciences of medicines like Unani, Ayuerveda, allopathic, Sidda, naturopathic and homeopathic. The present investigation deals with pharmacognostical and primary phytochemical screening of the pod of Albbizzialebbeck (L.) Benth. The pharmacognostical studies include fluorescence, organoleptic evaluation and physicochemical analysis. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 6, Issue 1, 2019 · pp. 10–15 Read article
-
Production and Partial Purification of Tannase from Bacillus sp.
Abstract: Micro-organisms tannase is industrial-important enzymatic enzymes can, through oxidation with secondary metabolites including such tannins, catalyze that production of Gallic acid or glucose. Tannase are commonly used in the production, drink, food processing and brewing and chemical industries. Tannic acid with low-value agro-industrial waste was also commonly used in manufacturing besides tannase production. Tannase also have huge 124–310 KDa variety with molecular weights as well as a great deal with …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 2, 2023 · pp. 42–51 Read article
-
Quantitative Determination of Isomeric Components of essential oils by RP-HPLC-PDA in multi-herbal tablets
Abstract: Essential oils are lipophilic and highly volatile secondary plant metabolites, principally mono- and sesquiterpenes. The widespread usage and applications in biopharmaceutics and cosmoceutics of these components drives their quality assessments criteria to be established. Gas chromatography is one of the predominantly used technique for analyzing volatile oils. Although Gas Chromatography employs estimation designs operated at elevated temperatures leading for plausible structural alterations of thermo labile compounds. Hence, a novel gradient …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 19–28 Read article