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155 articles for “genome”
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A Review of Recent Advancements in Machine Learning and Deep Learning Approaches for Pet Diseases Prediction
Abstract: This systematic study assesses recent developments in Machine Learning (ML) and Deep Learning (DL) approaches to predict pet diseases. With the increasing role of Artificial Intelligence (AI) in pet healthcare, this study identifies recent research trends, limitations, and future directions. A comprehensive search was done using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines in selecting 20 relevant studies from over 300 articles published between 2020 and …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 3, 2025 · pp. 1–6 Read article
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Veterinary Immunology in Zoonotic Disease Control
Abstract: Zoonotic diseases, which are transmissible between animals and humans, pose a significant threat to global public health, food security, and economic stability. Veterinary immunology plays a pivotal role in understanding host–pathogen interactions, developing preventive strategies, and mitigating the impact of these diseases. Animals serve as reservoirs for a variety of pathogens, including viruses, bacteria, and fungi, which can persist asymptomatically or cause clinical disease. Understanding the immune mechanisms in both …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 3, 2025 · pp. 36–43 Read article
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CTCHFA: Discovery of Circulating Tumor Cells in Metastatic Breast Cancer and Nonmetastatic Cancer by using Novel Hybrid Hierarchical Clustering Algorithm in Firefly Distance
Abstract: AbstractBlood testing for circulating tumor cells (CTCs) has emerged as one of the highest fields in cancer research. CTC detection are an early gene marker of reaction to systemic therapy, whereas their molecular characterization has a strong field that can be translated to individualized targeted treatments and spare breast cancer (BC) patients from unnecessary and ineffective therapies. Genomic research regarding CTCs monitoring for BC is limited due to the lack …
Published in Journal of Computer Technology & Applications · Vol. 6, Issue 1, 2015 · pp. 9–18 Read article
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Reverse Pharmacology: A Gateway to Validation of Efficacy of Natural Drugs
Abstract: In spite of significant advances in genomics, proteomics, metabolomics and combinatorial chemistry in the present times, reverse pharmacology (RP) has led to deviation of drug discovery and development from its regular or normal process or path. RP is a trans-disciplinary path which reverses the drug discovery and development process from lab-clinic to clinic-lab. Natural products (NPs) of Unani medicine or traditional system of medicine (TSM) provide vast potential for novel …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 9, Issue 3, 2020 · pp. 48–53 Read article
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Molecular Evolution of Virulence Genes of Coronavirus: A Computational Study
Abstract: Corona Virus i.e., Covid 19 is consider as highly pathogenic and transmissible, which is responsible for emerging scenario of current pandemic disease. The family of this virus Coronaviridae, which affect respiratory system of human along with animal, and It is belived to be originated from bat. The homology of covid 19 is mix of SARA-CoV and MERS-CoV. The Single-stranded positive genomic RNA, which is coated by nucleocapsid protein is present …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 2, 2021 · pp. 22–35 Read article
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Seroprevalence of Hepatitis E Virus and Serum Level of Serum Aspartate Transaminase (AST) and Alkaline Phosphatase (ALP) Among Jaundice Patients in Kathmandu Valley, Nepal
Abstract: Hepatitis E is an acute disease caused by hepatitis E virus that usually manifest as acute jaundice. It is a waterborne infection and occurs sporadically or as epidemic outbreaks. Hepatitis E virus (HEV) is a positive-stranded RNA virus with a 7.2 kb genome with three open reading frames In this study we report the seroprevalence of HEV in different categories of jaundice patients along with their elevation of serum bilirubin, …
Published in Research and Reviews: A Journal of Medicine · Vol. 4, Issue 3, 2014 · pp. 37–42 Read article
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RsaI polymorphisms of ER-β and Idiopathic Male Infertility
Abstract: Purpose: Study on association between estrogen receptor gene polymorphism and male infertility has been interested, but highly specific genetic markers have been reported to be variable according to regions and nations. Herein we studied to figure out whether ERβ gene1082 G>A polymorphism could influence on sperm indices or not.Method: We dealt with 100 Korean patients with idiopathic male infertility diagnosed at our university hospital as a study group and 127 …
Published in Research and Reviews: A Journal of Medicine · Vol. 12, Issue 3, 2022 · pp. 34–41 Read article
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The Predatory Bacteria, Bdellovibrio and Like Organisms (BALOs): An Emerging Savior for Human Welfare
Abstract: Bdellovibrio and like organisms (BALOs) are capable of killing other Gram negative pathogenic and non-pathogenic bacteria dwelling in a diverse environmental niches such as soil, freshwater and ocean. The predatory nature of BALOs can be a viable alternative to conventional use of antibiotics to treat ocular, periodontal, respiratory and fish pathogen infections since the incessant use develops resistance against them. Unique property such as potential to survive in ecologically hazardous …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 3, 2018 · pp. 19–33 Read article
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Nitric Oxide Synthase (NOS) in Breast Carcinoma
Abstract: Breast cancer is the most alarming problem of the current time. Nitric oxide, a free radical gas is synthesized by isoenzymes called nitric oxide synthase. Nitric oxide synthase consists of three isoforms; Nitric oxide produced is cytotoxic which is known to inhibit the DNA synthesis causing its damage. Keeping this in mind, nitric oxide synthase was determined in breast cancer and normal breast tissue. For this tissue from 60 breast …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 1, 2018 · pp. 23–28 Read article
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Arsenic as a Cause of Cancer
Abstract: Inorganic Arsenic (iAs) is a pervasive and ubiquitous environmental toxin that has created world-wide human health problems. Populations exposed to high concentrations of arsenic-contaminated drinking water suffer serious health consequences ranging from acute toxicities to development of malignancies, including alarming cancer incidence and death rates. Epidemiologic studies have shown a relationship between chronic arsenic exposure and disease of the skin, lung, urinary bladder, and conceivably liver, kidney, and prostate in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 3, 2016 · pp. 8–21 Read article
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Advances in Lung Cancer Detection and Diagnosis: An Integrative Approach Using Computational Chemistry, Statistics, Bioinformatics, Artificial Intelligence, and Machine Learning
Abstract: Lung cancer is still one of the most common and lethal cancers globally, accounting for more than a million deaths each year. Prompt detection is important, and imaging techniques like chest X-rays, MRIs, PETs, CTs, and molecular imaging have become important tools. But still, even though all these techniques do not provide an accurate classification of the lesion, they have led to the development of computer-based high-resolution image analysis. Computer …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 2, 2026 Read article
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Unveiling Actionable Pathogenic Genes for Precision Oncology in Brain Cancers: Glioblastoma and Astrocytoma
Abstract: Glioblastoma (GBM) and astrocytoma are aggressive primary brain tumors characterized by significant molecular heterogeneity, complicating effective treatment. This study employed targeted next-generation sequencing of 529 cancer-associated genes on matched tumor-normal pairs from GBM and astrocytoma patients. Somatic variants were identified using a rigorous bioinformatic pipeline adhering to GATK Best Practices, with variant allele frequencies (VAF) calculated to assess clonal dominance. Functional annotation and driver mutation classification were performed using Ensemble …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 · pp. 43–59 Read article
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CRISPR-Based Enhancement of Secondary Metabolites in Artemisia annua: Focus on Artemisinin Biosynthesis
Abstract: Medicinal plants are natural biofactories producing secondary metabolites with significant therapeutic value, including terpenoids, alkaloids, and phenolics. Among these, artemisinin, a sesquiterpene lactone from Artemisia annua L. is the cornerstone of global antimalarial therapy along with additional anticancer, antiviral, and antimicrobial activities. However, artemisinin content in the native plants is inherently low (typically 0.01–0.8% dry weight), restricting affordable and consistent supply. Conventional approaches to increase production include classical breeding, singlegene …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 2, 2026 · pp. 23–35 Read article
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A Comprehensive Review: Personalized Treatment Strategies in Stable Ischemic Heart Disease
Abstract: Stable Ischemic Heart Disease (SIHD) is one of the leading cardiovascular disorders associated with high morbidity and mortality worldwide. Since early symptoms such as chest pain, fatigue, and shortness of breath are often non-specific and difficult to recognize, diagnosis becomes challenging, and many cases remain undetected until advanced stages or complications occur. Traditional diagnosis depends heavily on clinical evaluation, electrocardiography, stress testing, and imaging techniques. The development of improved treatment …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 Read article
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Next-Generation Biorepositories: Accelerating Infectious Disease Research and Vaccine Innovation
Abstract: Next-generation biorepositories have emerged as critical infrastructure for advancing infectious disease research and accelerating vaccine development. By integrating cellular, genomic, and clinical data within harmonized frameworks, these repositories overcome traditional limitations of fragmented datasets and limited interoperability. The evolution from conventional biobanks to digitally enabled, multi-omics platforms has enabled comprehensive analysis of pathogen–host interactions, facilitating the identification of novel vaccine targets and correlates of protection. The COVID-19 pandemic underscored the …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 Read article