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92 articles for “enrichment”
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Gene Expression Profiling in Autism Spectrum Disorder: A Microarray Analysis Using Gse42133
Abstract: Autism Spectrum Disorder (ASD) is a diverse neurodevelopmental disorder characterized by difficulties in social interaction, communication impairments, and restricted or repetitive patterns of behavior. Despite its increasing prevalence, the underlying molecular mechanisms remain poorly understood. Advances in transcriptomics offer opportunities to investigate the gene expression changes that may contribute to ASD pathophysiology. In this study, the microarray dataset GSE42133 was analyzed, which comprises gene expression profiles from peripheral blood samples …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 37–48 Read article
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Punjab’s Wetlands as Inland Analogues of Marine Ecosystems: Status, Stressors and CommunityLed Conservation.
Abstract: Aquatic and wetland ecosystems in Punjab, India, represent ecologically significant yet increasingly degraded socioecological systems embedded within an intensively managed agrarian landscape. Despite their recognised importance, existing studies largely treat these systems using conventional freshwater ecological frameworks, with limited integration of microbiologically mediated processes and broader ecosystem theories. A key research gap, therefore, lies in the lack of interdisciplinary approaches that can holistically interpret wetland structure, function, and governance across …
Published in International Journal of Marine Life · Vol. 3, Issue 1, 2026 · pp. 31–51 Read article
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Integrating Advanced Technologies for the Scientific Revalidation of Ayurvedic Principles
Abstract: Background: Ayurveda, a 5,000-year-old holistic healthcare system, emphasizes the dynamic balance of body, mind, and spirit. Recent advancements in science and technology have accelerated its integration into global healthcare systems. Objective: This paper explores the contribution of modern tools and methodologies to the scientific validation and enhancement of Ayurvedic principles across education, clinical practice, and research. Methods: A comprehensive literature review was conducted using databases like PubMed, Google Scholar, and …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 1–6 Read article
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Optimizing Airline Efficiency Using Big Data and Predictive Analytics
Abstract: Recent technological advancements have resulted in the generation of vast volumes of data across industries, including the airline sector, supporting operational control and service quality. Big Data Analytics (BDA) enables organizations to analyze large and complex datasets to derive actionable insights that support informed decision – making and superior operational performance. This review paper systematically analyzes twenty relevant research studies to explore the application of Big Data Analytics (BDA) within …
Published in Journal of Advanced Database Management & Systems · Vol. 13, Issue 1, 2026 Read article
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AI-Driven Inverse Design of Functionally Graded Bio-Nanocomposites for Sustainable High-Barrier Packaging
Abstract: Multilayer plastic packaging realizes high barrier performance through laminated heterogeneous structures, but the heterogeneous structure has severe end-of-life challenges caused by the interfacial incompatibility of materials and the poor recyclability. This study proposes the inverse design of functionally graded PLA-nanoclay composite films by reinforcement learning as a monolithic alternative to traditional multilayer systems. Twin-screw extrusion is designed as a continuous control Markov decision process, and proximal policy optimization (PPO) is …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1547–1564 Read article
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Upgrading Nutritive Value of Rice Straw: Processing, Supplementation, and Agronomic Innovations for Improved Utilization
Abstract: Rice straw, a major byproduct of rice production, holds significant potential as a livestock feed but is constrained by its high lignocellulosic content, low crude protein, and poor digestibility. Enhancing its nutritive value is imperative for sustainable livestock production. This study explores a range of innovative strategies aimed at improving rice straw’s digestibility and overall nutritional quality. Physical processing techniques, including chopping, grinding, soaking, and steam treatment, enhance its surface …
Published in Research & Reviews : Journal of Botany · Vol. 15, Issue 1, 2026 · pp. 42–58 Read article
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Microbially Modified Sustainable Cementitious Composites Using Industrial Ash Fillers
Abstract: The growing demand for sustainable, durable construction materials has driven the development of bio-engineered cementitious composites incorporating industrial by-products and self-healing mechanisms. This study investigates a microbially modified cementitious composite that integrates industrial ash fillers with bacteria-based self-healing technology to enhance mechanical performance and microstructural integrity while reducing cement consumption. Cement was partially replaced with industrial ash at 20%, 30%, and 40% replacement levels, and a uratolytic bacterial strain (Bacillus …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 331–350 Read article
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Formulation and Evaluation of Herbal Skin Cream
Abstract: Herbal cosmetics have gained significant attention in recent years due to increasing consumer preference for natural and safe skincare products. Herbal skin creams are semisolid formulations enriched with plant-derived ingredients that provide therapeutic as well as cosmetic benefits. These formulations are designed to enhance skin health by utilizing bioactive phytoconstituents such as flavonoids, alkaloids, tannins, essential oils, and vitamins. Herbal creams are generally prepared using oil-in-water (O/W) or water-in-oil (W/O) …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 20–32 Read article
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Differential Gene Expression Analysis of Human Atrial Fibroblasts Reveals Dysregulation of RNA Metabolism and Translational Machinery in Atrial Fibrillation
Abstract: Atrial fibrillation (AF) is a complex cardiac arrhythmia characterized by extensive structural remodeling and the activation of atrial fibroblasts, which drive the progression of fibrosis. To identify the underlying transcriptomic alterations, we analyzed six human atrial fibroblast RNA-Seq datasets (three control and three AF) retrieved from the Sequence Read Archive. After performing rigorous quality control and adapter trimming, we aligned the reads to the GRCh38 human reference genome using a …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 · pp. 15–25 Read article
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Mass Spectrometry–Based Phosphoproteomic Markers to Predict Kinase Inhibitor Response in Solid Tumors
Abstract: Mass spectrometry-based phosphoproteomics has emerged as a powerful tool for predicting kinase inhibitor responses in solid tumors, offering direct functional insights into signaling pathways that surpass traditional genomic profiling by capturing dynamic kinase activities and adaptive resistance mechanisms. Technological breakthroughs, including data- independent acquisition (DIA), trapped ion mobility spectrometry (timsTOF), and efficient enrichment methods like TiO2 or IMAC, now enable comprehensive profiling of over 40,000 phosphorylation sites from limited clinical …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article
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White-Rot Fungi-Based Bioprocessing for Circular Bioeconomy & Valorization of Lignocellulosic Waste
Abstract: The escalating global demand for sustainable resource management and the imperative to reduce dependence on fossil-based products have positioned the circular bioeconomy as a transformative paradigm for the 21st century. Lignocellulosic biomass, generated abundantly as agricultural and forestry residues, constitutes one of the most underexploited renewable carbon sources on Earth, yet its recalcitrant structure, interlinking cellulose, hemicellulose, and lignin, has long impeded its efficient valorization. White-rot fungi (WRF), predominantly belonging …
Published in International Journal of Fungi · Vol. 3, Issue 2, 2026 Read article