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292 articles for “conclusion”
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article
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Sliding Mode Control of SolidWorks Designed Robotic Manipulator Co-simulated in MATLAB
Abstract: This study proposes a Sliding mode control (SMC) algorithm for controlling three degrees of freedom (3DOF) robotic arm. This concept was inspired by seeing the increasing of potential applications of robotic arm in automation industry, mainly in the applications like pick and place. The 3DOF robotic arm is designed in SolidWorks and then it is imported to MATLAB for simulation purposes. Initially, simulations are done by using the conventional PID …
Published in International Journal of Advanced Control and System Engineering · Vol. 1, Issue 1, 2023 · pp. 7–14 Read article
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Zero Trust Security Governance by Utilizing Identity and Access Management
Abstract: The Zero Trust Paradigm, a more stringent approach to network security, operates on the fundamental concept of “Never Assume, Always Authenticate.” It is currently being implemented in different countries to align with their national cybersecurity and access management governance policies. The differentiation of these Zero Trust systems is contingent upon factors such as awareness, infrastructure, expenses, and security demand. Additionally, the identity-based access management models within the Zero Trust system …
Published in International Journal of Mobile Computing Technology · Vol. 1, Issue 2, 2023 · pp. 6–17 Read article
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A Study of climate change and its impact on tourism
Abstract: Tourism is clearly linked to climate, as vacationers wish spending time in open-air and travel to delight in the sky or countryside. It is then amazing that the tourism works pays slight thoughtfulness to climate and climatic transformation. Numerous of investigations on tourism and climate change is, still, beginning to raise. Though it is a generally known statement that climate change can adversely effect on tourism sector and shake the …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 2, Issue 1, 2024 · pp. 1–10 Read article
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Assessment of Finerenone Safety and Efficacy in Individuals with Type 2 Diabetes and Chronic Kidney Disease
Abstract: Background: In this work, we provide strong evidence for the safety and efficacy of finerenone in people with type 2 diabetes and chronic kidney disease. Our goal is to improve patients' quality of life and general well-being through our research. Aim: Finerenone exhibited a significant decrease in the likelihood of renal and cardiovascular (CV) events in individuals with both type 2 diabetes and chronic kidney disease. This exploratory subgroup analysis …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 06–09 Read article
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Exploring the properties and extraction of neem leaves
Abstract: Neem (Azadirachta indica) is a versatile medicinal plant, for its diverse therapeutic properties. This abstract provides a comprehensive overview of recent research focusing on phytochemical analysis, biochemical characterization, and antimicrobial susceptibility testing of Neem extracts. Utilizing the different from of chemical used in it, phytochemical analysis identified a plethora of secondary metabolites within Neem, including alkaloids, flavonoids, terpenoids, steroids, saponin, tannins, quinone, and phenolic compounds, indicative of its complex chemical …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 32–39 Read article
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Deciphering Th-Related Gene Interactions in Chronic Spontaneous Urticaria: Bioinformatics Insights and Drug Affinity Exploration
Abstract: Objective: There has been a great deal of interest in how inflammatory dermatosis and The cell interact, but the etiopathogenesis of chronic spontaneous urticaria (CSU) is still inadequately comprehended. Through bioinformatics techniques, the purpose of this work is to elucdate the molecular mechanism underlying Th-related genes in CSU and seeks to find the highest affinity drug. Methods: The CSU RNA expression profiling dataset provided the basis for the investigation. The …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 1–15 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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Recombinant Insulin
Abstract: Recombinant insulin, a revolutionary product of biotechnology, has transformed the landscape of diabetes treatment. Developed through genetic engineering techniques, recombinant insulin offers a safer, more consistent alternative to traditional animal-derived insulin. Its production involves the insertion of the human insulin gene into host organisms such as Escherichia coli or Saccharomyces cerevisiae, which serve as efficient factories for insulin synthesis. Recombinant insulin is used to treat diabetic patients who are allergic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 39–43 Read article
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Optimizing Manufacturing Processes with Taguchi Method in Production Engineering
Abstract: The Taguchi Method, pioneered by Genichi Taguchi, stands as a powerful optimization tool within the realm of production engineering. This paper delves into the principles, applications, and significance of the Taguchi Method in enhancing manufacturing processes. With a focus on minimizing variation and improving performance, this methodology plays a crucial role in addressing challenges faced by industries in their pursuit of operational excellence. The core components of the Taguchi Method, …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 1, Issue 2, 2023 · pp. 1–8 Read article
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Integrated risk assessment framework for mixed use real estate development: Retail–office configuration
Abstract: Mixed-use real estate development is a multifaceted challenge that offers significant potential benefits, yet developers and urban planners face skepticism and uncertainty. Despite the promise of enhancing property values, promoting secure neighborhoods, stimulating economic vitality, and creating synergies, the associated risks demand a critical examination. This research seeks to address this gap by constructing a comprehensive risk assessment framework for mixed-use real estate projects. The literature review underscores the substantial …
Published in International Journal of Rural and Regional Development · Vol. 2, Issue 1, 2024 · pp. 22–36 Read article
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Liminality and Urban Acceptance: A Case of Majnu ka Tilla, Delhi
Abstract: This paper recognizes liminality as an important urban phenomenon that has an impact on lived experiences in the city. Looking through the lens of liminality allows an incorporation of a multilayered and processual approach that recognizes the in betweenness and ambiguities in the urban. To do so, the Tibetans exile community settlement of Majnu ka Tilla in Delhi, identified to be in a state of permanent liminality that is embedded …
Published in International Journal of Urban Design and Development · Vol. 2, Issue 1, 2024 · pp. 36–46 Read article
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Crystal Engineering Strategies for Tailoring Mechanical Properties of Structural Materials
Abstract: Crystal engineering has emerged as a promising approach for designing materials with tailored mechanical properties, enabling advancements in various fields such as aerospace, automotive, and construction. This review examines the diverse strategies employed in crystal engineering to manipulate the mechanical behavior of structural materials. One key strategy involves controlling the crystal structure at the atomic level through techniques such as alloying, doping, and phase transformations. Alloying introduces foreign atoms into …
Published in International Journal of Crystalline Materials · Vol. 1, Issue 1, 2024 · pp. 01–06 Read article
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Mixed use settlements in a metro city: Effects on people & context
Abstract: Mixed-use settlement is a building or a combination of buildings designed to functionally and physically integrate multiple uses such as commercial, institutional, recreational, and other uses along with residential uses. In such spaces, there are more opportunities for pedestrian activities due to the presence of a majority of the daily necessities at near distances. How public spaces are designed plays a significant role in affecting one’s mental state and sense …
Published in International Journal of Urban Design and Development · Vol. 2, Issue 1, 2024 · pp. 22–35 Read article
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An Evaluation of CNN and SVM Algorithms for Facial Recognition
Abstract: With the use of facial recognition technology, someone's identity can be confirmed or identified. Real-time or picture-based facial recognition technology can be used to identify individuals. One of the most important elements in the field of biometric security is facial recognition. The technology is mostly used in the fields of law enforcement and defence, while interest in other fields is growing. To recognize the face, numerous technologies and algorithms were …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 1, Issue 2, 2023 · pp. 12–19 Read article
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Importance of inflammatory marker ratio and lipid profile ratio in Acute Ischemic Stroke
Abstract: Background: Acute Ischemic Stroke is a chronic inflammatory disease that is projected to be one of the leading causes of mortality affecting millions of people globally. It is essential to study the Platelet lymphocyte ratio (PLR), Neutrophil lymphocyte ratio (NLR) ratios and C reactive protein (CRP) in impacting the inflammatory status during stroke. It is also important that altered lipid metabolism could influence the inflammatory conditions associated with AIS. Hence …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 19–31 Read article
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A Narrative Review on an Insight of Herbal Origin Drugs and Their Traditional Medicine Formulations for the Treatment of Nephrolithiasis
Abstract: Ethnopharmacological relevance. There is no satisfactory treatment at present to cure or prevent kidney stone recurrences using predictable medicines. There are several marketed formulations in Ayurveda, Unani and Homeopathic Traditional Medicines (TM) have potential lithotriptic effects and clinical applications. In India, prevalence rates of complementary and alternative medicine (CAM) for the treatment of nephrolithiasis are being estimated at 63.9%. Aim of the review This review article intended to scientifically documented …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 1, 2024 · pp. 14–30 Read article
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Assessing Efficacy and Safety: Oxytocin Monotherapy vs. Oxytocin + Carbetocin Combination Therapy
Abstract: Objective: Comparing the Effectiveness between Oxytocin monotherapy and Oxytocin + Carbetocin. Methods: A prospective, non-randomized, observational study focusing on 221 women with CS was conducted. The patients eligible based on inclusion and exclusion criteria were screened and final sample size was 139. Individual patient data including patient demographics, medical history, OT notes, pre and post CBC reports, and safety data were obtained from the patient records. The study compared between …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 1, 2024 · pp. 40–51 Read article
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Tropical Medicine and Leishmaniasis: Unraveling the Complexities of a Neglected Tropical Disease
Abstract: Protozoan parasites of the genus Leishmania are the cause of the vector-borne disease leishmaniasis, which poses a serious threat to global public health in tropical and subtropical areas. Despite being common and having a significant effect on human health, leishmaniasis is still a neglected tropical disease, with little funding available for investigation and prevention. This article examines the relationship between leishmaniasis and tropical medicine, emphasizing the particular difficulties this intricate …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 2, 2024 · pp. 29–39 Read article
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Blockchain Technology: Comprehensive Review and Future Directions
Abstract: Blockchain technology has emerged as a transformative power, restructuring sectors by offering increased security, transparency, and decentralization. This research paper serves as a comprehensive examination of blockchain, aiming to dissect its intricate structure, explore its myriad applications, confront existing challenges, and envision future advancements. At its core, the problem addressed herein is the imperative to comprehend the present landscape of blockchain technology, discern its limitations, and chart a course toward …
Published in International Journal of Computer Science Languages · Vol. 2, Issue 1, 2024 · pp. 33–38 Read article