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89 articles for “anticancer property”
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Soursop Phytocompounds as Potential Anticancer Agents: A Molecular Docking Study
Abstract: Objective: According to tumor statistics, there will be a total of approximately 1,958,310 new malignancy cases, that balances to nearly 5,370 cases day by day. Without any questions its clearly evident that cancer is considered as one of the deadliest diseases of mankind. The course of this study emphasizes on computational approach for finding new drug for potential target proteins Bcl-2 (4MAN) and Mcl-1(5FDO) by docking against soursop (Annona Muricata …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 18–39 Read article
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Piezoelectric Nanoparticles Loaded with Curcumin for Cancer Treatment
Abstract: Conventional cancer chemotherapy treatments are often compromised by systemic toxicity which starts from the lack of tumor specificity of administered anticancer drugs. The side effects limit the dose of the drug that can be administrated, making effective cancer treatment difficult. Nanoparticle-based drug delivery has the potential to overcome this challenge by targeted delivery to tumor and taking the advantage of tumor’s natural leaky vasculature to increase the accumulation of drug-loaded …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 6, Issue 2, 2016 · pp. 1–6 Read article
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1,2,3,4-Tetrahydroquinoline: A Versatile Nucleus in the New Millennium
Abstract: Tetrahydroquinoline nucleus containing molecules are well known for their presence in natural products mainly in alkaloids, which constitute the active class of compounds possessing wide spectrum of biological activities. Tetrahydroquinoline skeleton is often used for the design of several synthetic compounds with diverse pharmacological properties. An immense wide range of pharmacological utility of such nucleus has inspired many synthetic and medicinal chemists to develop novel strategies for their synthesis, which …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 1, 2016 · pp. 1–18 Read article
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In-silico Approach of Few Selected Phytoconstituents on Newer Cancer Targets
Abstract: Background: Cancer’s high death rates are mainly due to, drug resistance and unmet medical demands. It necessitates novel anticancer medications. AI tools aid in efficient and faster drug discovery by analyzing data, modeling processes and optimizing pipeline stages. Aim: The aim of this present study is to evaluate phytoconstituents against novel and newer cancer targets. Methodology: The ligands Daidzein, Resveratrol and Genistein were targeted against the Glutamate dehydrogenase (PDB ID …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 12–17 Read article
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Design and Evaluation of Thermo-Responsive Poly(N-isopropylacrylamide)-Based Polymeric Nanoparticles for Temperature-Triggered Intratumoral Release of Doxorubicin in Solid Tumors
Abstract: Thermo-responsive polymeric systems have emerged as promising platforms for targeted intratumoral drug delivery in cancer therapy. This study aimed to develop and evaluate poly(N-isopropylacrylamide) (PNIPAM)-based polymeric nanoparticles as intelligent carriers for temperature-responsive delivery of doxorubicin (DOX) to solid tumors. Nanoparticles were synthesized via free radical polymerization using N-isopropylacrylamide as a thermoresponsive monomer and N,N′-methylenebisacrylamide as a crosslinker, forming a stable network with a tunable lower critical solution temperature (LCST).The optimized …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 159–168 Read article
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Phytochemical profiling and LC/MS analysis of Selaginella bryopteris (L.) Baker
Abstract: Selaginella bryopteris (L.) Baker, an endemic pteridophyte is found restricted to the Indian subcontinent mostly because of its environmental requirements of cool temperatures and optimum water availability. It is a drought-resistant species and shows curling in limited water supply reviving when water conditions are restored. This property makes this species a suitable plant for exploration of medicinal properties, although its restricted occurrence has limited this evaluation. The current study explores …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 1, 2025 · pp. 46–51 Read article
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Novel Synthesis of Encapsulated Super Paramagnetic Iron Nanoparticles (Fe3O4) and its Evaluation in Drug Delivery System
Abstract: Nanoparticles can be defined as solid, submicron, colloidal particles ranging in size from 10–100 nm in diameter, generally but not necessarily made of natural or synthetic polymers, in which drugs can be adsorbed, entrapped, that exhibit new or enhanced size-dependent properties as compared to microparticles. Iron oxide nanoparticles are often magnetic by nature, which means that they obey Coulomb’s law, and can be manipulated by an external magnetic field gradient. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 2, 2016 · pp. 11–24 Read article
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Green Synthesis of Silver Nanoparticles Using Ficus Religiosa Linn Leaf Extract
Abstract: Nanotechnology is always a promising field for many new technological innovations. Turning Chemical process green also gains more attention of researchers due to high environmental concern. The process that involves ecofriendly procedures, use of less toxic solvents, less toxic byproducts, use of cheaper raw materials are all becoming ever increase in demand for current research scenario. Plants especially those having medicinal properties are beneficial for synthesizing nanoparticles as it will …
Published in Journal of Catalyst & Catalysis · Vol. 8, Issue 2, 2021 · pp. 45–52 Read article
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Oxadiazole Derivatives Recent Progress in Synthesis and Bioactivity
Abstract: Over the past few decades, significant advancements have been made in the development of heterocyclic derivatives, leading to the production of numerous novel agents, both synthetic and natural in origin. Because of its numerous biological properties, including antibacterial, antiviral, and antifungal properties, thiazole is a special five-membered heterocyclic motif among heterocyclic compounds. It is utilized as a fundamental building block in many pharmaceutically significant compounds. To the best of our …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 62–67 Read article