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480 articles for “Drug Delivery”
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Recent Advances and Technologies in Transdermal Drug Delivery System
Abstract: Transdermal drug delivery system is usually well liked by patients and second in terms of preference after oral route. The global market for transdermal system is expected to rise in near future. Skin is considered to be the major barrier in transdermal delivery. However, few technologies and advances such as radiofrequency, ultrasound, electroporation, iontophoresis, and microneedle have been identified to overcome these barriers. Systems or devices that incorporate these technologies …
Published in Trends in Drug Delivery · Vol. 3, Issue 1, 2016 · pp. 38–45 Read article
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Microemulsion: Novel Carrier for Drug Delivery
Abstract: Since the discovery of much novel formulation belongs to the lipid based drug delivery system, the handicapped property of drug molecule reverted to the fittest, doable and easily delivered with strategies of improving bioavailability and depleting dose of the same. Microemulsion system is clear, stable, isotropic mixture of oil, water and Smix (Surfactant and co-surfactant mixture), frequently in combination with a co-solvents. To date microemulsions have been shown to be …
Published in Trends in Drug Delivery · Vol. 3, Issue 1, 2016 · pp. 1–18 Read article
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Computer Simulations on Magnetic Particles Capturing in an Implant Assisted Channel for Targeted Drug Delivery
Abstract: In this paper, we studied the effect of magnetic field, inlet velocity and particle size on capture efficiency of magnetic particles transported in an implant assisted uniform channel through computational simulations. The dominant magnetic and drag forces are included in the simulations. The couple nonlinear Navier-Stokes equation for fluid flow and Newton’s second law equation for particle transport are solved using finite element based COMSOL multiphysics software. It is found …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 1–7 Read article
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An Overview on Natural Polymers in Novel Drug Delivery System
Abstract: Any pharmaceutical formulation contains two ingredients, one is the active ingredient and other is an excipient. An excipients help in the manufacturing of dosage form and it also improve physicochemical parameters of the dosage form. Polymer plays an important role as excipients in any dosage form. They influence drug release and it should be compatible, nontoxic, stable, economic etc. They are broadly classified as natural polymers and synthetic polymer. They …
Published in Trends in Drug Delivery · Vol. 3, Issue 2, 2016 · pp. 1–14 Read article
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Quality by Design (QbD) Approach for Optimization and Development of Nano Drug Delivery Systems
Abstract: To clearly understand the formulation of high quality pharmaceutical products, FDA generalized quality by design (QbD) in the field of pharmacy, which is based on the thorough understanding of how materials and process parameters affect the quality profile of final products. Quality by design is a risk management and science-based approach promoted by the United States food and drug administration to enhance pharmaceutical development throughout a product’s life cycle. The …
Published in Trends in Drug Delivery · Vol. 3, Issue 3, 2016 · pp. 23–32 Read article
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Development and characterization of Emulgel a Novel formulation for topical drug delivery of Ofloxacin
Abstract: The aim of this work is to develop best Emulgel formulation carrying Antifungal agent Ofloxacin Emulgel has been emerged as a promising drug delivery system. Formulation of Ofloxacin Emulgel was done by using Carbopol 934 as a gelling agent, liquid paraffin as hydrophobic phase, Tween-80 and span-80 as emulsifiers and surfactant. Ofloxacin has been used in pharmaceutical formulation since it has antimicrobial activity. It acts by inhibiting bacterial DNA gyrase …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 2, 2019 · pp. 19–23 Read article
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Self-Nanoemulsifying Drug Delivery System for Atorvastatin Calcium: Design, Optimization and Evaluation
Abstract: Atorvastatin calcium (ATC) is the choice of drug in the treatment of moderate to severe hypercholesterolemia. In the current study, ATC self-nanoemulsifying drug delivery systems (SNEDDS) were prepared in an attempt to improve the bioavailability by enhancing its solubility. The solubility of ATC in various oils, surfactants, and co-surfactants were determined. Based on their solubility, Capmul MCM (oil), Tween 20 (surfactant), propylene glycol (Co-surfactant) was selected for preparation of SNEDDS. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 2, 2015 · pp. 27–36 Read article
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Child-Friendly Innovation: A New Era in Pediatric Drug Delivery Systems
Abstract: Pediatric formulations are becoming more and more popular as a result of advancements in pharmaceutical delivery technology. For young patients, there isn't a safe and effective drug delivery system in place. Since children's pharmacokinetics and pathophysiologic profiles differ from those of adults, it is imperative to design and develop an innovative and appropriate delivery system to provide accurate and dependable medicine administration to pediatric patients. Discussions will be held under …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 · pp. 26–34 Read article
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Recent Trends in Ocular Drug Delivery: Challenges and Approaches
Abstract: Drug topically regulation can be accessed most easily in the eye. When given topically as eye drops, medication ocular bioavailability is quite low. Drug entry into specific ocular locations is complicated by the complex anatomy and physiology of the human eye. Research has long been interested in the topical administration of successful treatments. To provide a suitable ocular penetration and extend the duration of drug residence is their challenging task. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 22–38 Read article
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Exploring Chocolate’s Potential: A Review of Its Role in Drug Delivery and Health Benefits
Abstract: The abstract explores the versatile nature of chocolate, highlighting its role as a medium for drug delivery systems due to its resistance to microbial growth and rich nutritional profile. Medicated chocolate, infused with drugs, offers a palatable solution to enhance patient compliance, particularly among children, while stimulating serotonin production for added therapeutic benefits. Cocoa, abundant in polyphenols, contributes to chocolate's health advantages, including cholesterol reduction and cardiovascular health. Scientific evidence …
Published in Trends in Drug Delivery · Vol. 11, Issue 2, 2024 · pp. 16–24 Read article
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Pharmaceutical Bead Formulations: A Comprehensive Overview into Advanced Drug Delivery
Abstract: Pharmaceutical beads are a unique and flexible drug delivery vehicle that provides numerous possibilities to control the release of drugs, protect them, and increase their therapeutic performance. These beads make it possible to design several types of therapeutic regimens by incorporating active pharmaceutical ingredients in a polymeric or lipid matrix. This review discusses the bead technology in drug delivery from its inception to its present application, focusing on the most …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 78–100 Read article
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Transfersome and Its Importance in Drug Delivery
Abstract: Transferosomes are super adaptable lipid bilayer vesicles that can infiltrate the skin intactly. Each transferosomes comprises of at any rate one inward fluid compartment, which is encircled by a lipid bilayer with uncommonly custom fitted properties coming about because of the joining of "edge activators" into the vesicular layer. Transfersomes can disfigure and go through tight narrowing (from 5 to multiple times not exactly their own width) without quantifiable misfortune. …
Published in Trends in Drug Delivery · Vol. 7, Issue 3, 2020 · pp. 34–40 Read article
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Carbon Nanotubes: Revolutionizing Noval Drug Delivery Approach for Alzheimer's Disease
Abstract: The objective of the review was to comprehensively study the application of nanotechnology and investigate the potential of carbon nanotubes in serving as a drug delivery system to improve the condition of Alzheimer's disease. Alzheimer's disease, characterized as an irreversible and progressive cerebral disorder, presents clinical manifestations such as dementia, cognitive decline, altered personality, impaired motor function, confusion, and diminished cognitive planning. The neurodegenerative processes inherent in Alzheimer's disease stem …
Published in Trends in Drug Delivery · Vol. 10, Issue 3, 2023 · pp. 10–15 Read article
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A Novel Drug Delivery System - Microsphere
Abstract: Microspheres are the multi-particulate novel medication conveyance measurement structure, it contains the molecule size range from 1 to 50µ and typically round fit as a fiddle with free stream property. It generally known as "Microparticles". Microspheres are set up by covering the medication particles with the polymeric arrangement (which got in characteristic, semi-manufactured or engineered structure) to accomplish the controlled arrival of medication, which produce the drawn out activity with …
Published in Trends in Drug Delivery · Vol. 7, Issue 3, 2020 · pp. 27–33 Read article
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A Novel Liquid Crystal Drug Delivery for Transdermal Application
Abstract: The present study was aimed at the formulation of liquid crystals of acyclovir that will be incorporated into a transdermal patch. Liquid crystals serve as drug carrier and have a good penetration-enhancer property, due to the extensive similarity of these colloidal systems with the intercellular lipids in the stratum corneum. The liquid crystals were prepared using tween 80 as emulsifier, cetosteryl alcohol as emulsion stabilizer and double-distilled water. Liquid crystals …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 28–37 Read article
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Formulation and Evaluation of Transungual Drug Delivery of Fluconazole Using Permeation Enhancers Screened by Hydration of Nail Plate
Abstract: The objective of the work was to formulate nail lacquer containing fluconazole an antifungual drug for the treatment of onychomycosis. Onychomycosis, a common fungal nail infection affects the people. Topical and ungual therapy is limited because of the poor permeation of the drug through nail plate. Film base was prepared using varying concentration of cellulose acetate and ethyl cellulose as polymers. The permeation enhancers were screened by nail plate hydration. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 32–45 Read article
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Design of Nanoparticle Drug Delivery System for NonSteroidal Anti Inflammatory Agents in the Treatment of Autoimmune Diseases
Abstract: Aim: The aim of the present study is to develop nanoparticle drug delivery system for naproxen and ibuprofen. Methodology: Ibuprofen nanoparticles were prepared by nanoprecipitation technique. Naproxen nanoparticles were prepared by desolvation technique. By adapting continuous addition method and intermittent addition, five formulations were prepared with each polymer. The obtained nanoparticles were evaluated for particle size, zeta potential, yield, drug content, entrapment efficiency and loading capacity. In vitro drug dissolution …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 23, Issue 1, 2021 · pp. 26–33 Read article
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Efficacy of Chiropractic Combined with Local Ultraviolet Irradiation and Low-frequency Drug Delivery of Huangbaeksu in Knee Synovitis
Abstract: Synovitis of knee joint is an early inflammatory type of osteoarthritis which is a degenerative chronic condition that involves degradation of articular cartilage and synovium, producing joint pain, tenderness, and stiffness. The aim of the present study was to assess the efficacy of chiropractic combined with local ultraviolet irradiation and low-frequency drug delivery of Huangbaeksu in knee synovitis cases. A total of 60 patients with knee synovitis were randomized into …
Published in Research and Reviews: A Journal of Medicine · Vol. 13, Issue 1, 2023 · pp. 1–8 Read article
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Lipid Drug Conjugates: A Novel Approach for Drug Delivery A Systematic Review
Abstract: The lipid drug conjugates (LDCS) a novel lipid based nanoparticles which has been extensively employed for the delivery and targeting of drugs. These have been exploited for many features in the field of pharmaceutical technology. The lipid drug conjugates have a 33% drug loading capacity more than the solid lipid nanoparticles (SLNs). The lipid drug conjugates have the potential to act as a delivery system for hydrophilic and lipophilic drugs, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 3, 2012 · pp. 1–8 Read article
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A Review on: Oral Thin Films: A New Approach to Effective and Easy Drug Delivery
Abstract: Oral Thin Film (OTF) is an advance drug delivery system in which drug is incorporated into dissolvable strip and place in oral cavity for rapid absorption. OTF is useful for patient such as pediatric and geriatric who have difficulty swallowing pills. It provides rapid action, precise dosage and improved bioavailability. OTFs consist of fast-dissolving films, extended-release films, and mucoadhesive films for various therapeutic applications. The manufacturing processes of OTFs such …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 22–41 Read article