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1972 articles for “4-dioxopyrimidine-5-carbonitrile” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
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Study of Electrochemical and Mechanical Properties of Graphene/HAp Composite Coating on Ti-13Nb-13Zr Alloy via Electrophoretic Deposition for Biomedical Application
Abstract: Titanium-13niobium-13zirconium alloy has widespread potential in biomedical applications due to its high degree of biocompatibility, favourable mechanical properties, high corrosion resistance, and high possibility of osseointegration. The surface was improved by electrophoretic deposition method using hydroxyapatite and graphene (5 g nanoHAp) (5 g nanoHAp+0.06 nanoGr) and suspended in ethanol solution at different conditions of time (1, 3, and 7 minutes) and voltage (50, 70, and 100 V). The effect of …
Published in Journal of Polymer & Composites · Vol. 11, Issue 2, 2023 · pp. 91–106 Read article
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Experimental Study on Fresh and Mechanical Properties of Crimpled Steel Fibers in Self-compacting Concrete
Abstract: The flow and strength characteristics of fiber-reinforced self-compacting concrete (SCC) with different aspect (l/d) ratios of fibers are recommended to be studied. After achieving a satisfactory SCC mix, crimped steel fibers with l/d ratio 30 are designated as CSF30; with l/d ratio 40 are designated as CSF40, with l/d ratio 50 is designated as CSF50 and with l/d ratio 62.5 is designated as CSF62.5 fibers are added at a fixed …
Published in Journal of Polymer & Composites · Vol. 11, Issue 1, 2023 · pp. 65–75 Read article
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Activity Quantification of Lu-177 SPECT/CT Imaging for Calibration Factor Analysis in Clinical Radionuclide Dosimetry
Abstract: Purpose: To evaluate the calibration factor (CF) at three-time points with the same protocol & acquisition parameters for the images of Lu-177 activity, scanned by two different SPECT/CTs (GE & MEDISO) using a cylindrical Jaszczak phantom with cold inserts, filled with uniform activity in water and to analyze the changes in the calibration factor data with time. The purpose of the study is to quantitatively analyze the first step (calibration …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 12, Issue 2, 2024 · pp. 9–22 Read article
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Mechanical Properties Investigation of Green Waste Composite Material
Abstract: Widespread accessibility and abundance of natural fibres are driving forces behind renewed focus on eco-friendly solutions. Researchers have recently begun to focus on natural fibres as reinforcement due to their many advantages over more conventional materials. Natural fibre is an attractive ecological and biodegradable alternative to most common glass fibre, synthetic reinforcement, because of its high specific and low cost mechanical capabilities. India is home to a wealth of untapped …
Published in Journal of Polymer & Composites · Vol. 11, Issue 4, 2023 · pp. 28–36 Read article
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Minimum Energy Criteria for Machining to Determine Energy-Productivity Relationship
Abstract: In this research segment, cutting rates were changed while depth of cut and feed rate remained fixed. The results of cutting using a standard uncoated carbide insert were compared. Cutting speeds were maintained at a constant. After determining the optimal cutting condition for the equipment and material. To determine optimal tool life and cutting speed, turning operations were performed. In industrial cutting operations, flank wear reduces tool life. For single-point, …
Published in Journal of Polymer & Composites · Vol. 11, Issue 4, 2023 · pp. 81–94 Read article
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A Molecular Docking Study: Targetting HIV-1 Integrase Protein Against Selected Phytocompounds from Calophyllum Lanigerum
Abstract: Objectives: The most common form of HIV that causes AIDS is HIV-1. The World Health Organization has estimated roughly 75 million plus HIV-1 infections till date and roughly 40 million deaths (as of 2021). Thus, this study was done to identify natural compounds from Calophyllum lanigerum, a medicinal plant largely endemic to South-East Asia, to inhibit the spread of this disease. It did so by using molecular docking methods, Lipinski …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 43–55 Read article
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Effect of Energy, Lysine and Energy/Lysine Ratio on Growth Performance Nutrient Digestibility and Serum Profile of Growing Locally Adapted Turkey
Abstract: This study investigated the effects of different levels of energy, lysine and energy/lysine ratios on growth performance, nutrient digestibility, and serum biochemical indices of locally adapted turkeys. The experiment lasted for 28 days. A total of one hundred and forty-four, 4-weeks old locally adapted turkey poults were completely randomized to six dietary treatments in a 2×3 factorial arrangement, replicated twice at 12 poults per replicate. Six diets were formulated. Diets …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 01–08 Read article
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Impact of Education on Knowledge and Perception of Antenatal Care Among Primigravida Mothers, Residing in Farasan, Kingdom of Saudi Arabia: A Community-based Interventional Study
Abstract: Pregnancy is one of the most cherished phases in the life of a woman. This timeframe holds immense importance for both the mother and the infant. Offering appropriate prenatal care during pregnancy is crucial for the health of the mother and the growth of the foetus. It provides a chance to promote sound parenting techniques and healthful conduct. The quality of prenatal care contributes to sustaining overall well-being throughout an …
Published in International Journal of Women's Health Nursing And Practices · Vol. 1, Issue 2, 2023 · pp. 6–13 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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Effectiveness of Sensitization Program on Knowledge of School Children Regarding Refractive Errors
Abstract: The human eyes are portals of absorbing divine knowledge from the surrounding world. These two precious pearls need to take proper care throughout to taste life. The eye care starts right from birth onward and becomes keenly required in children's school age as they use these gifts for intense learning. The neglected care in the initial years may trouble them with various visual disorders and disturb their studies too. Well-structured …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 13–20 Read article
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Oral Self-examination: An Approach for Early Recognition of Oral Cancer Among Factory Workers: An Experimental Study
Abstract: Background: Cancer is a worldwide concern and ranks among the most dreaded illnesses across the globe. Oral cancers are one common cancer among all cancers. Objectives: To measure the existing knowledge concerning oral self-examination for timely recognition of oral cancer among factory workers and to develop and administer a planned health education programme of oral self-examination for early recognition of oral cancer among factory workers. 40 factory workers were selected …
Published in International Journal of Oncological Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 22–26 Read article
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An approach of Computer Vision Methods for Driver’s Drowsiness and Yawn Detection
Abstract: Numerous studies have demonstrated that 4,444 traffic crashes are primarily caused by driver drowsiness. Due to advancements in digital computer systems, tiredness behaviour may now be studied by researchers worldwide. The goal of this project is to increase road safety by preventing accidents caused by sleepy drivers. To view the driver's face, use real-time facial recognition technology. A driver's attentiveness and reaction time may be impacted by weariness, which raises …
Published in International Journal of Optical Innovations & Research · Vol. 1, Issue 1, 2023 · pp. 21–26 Read article
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Zolmitriptan Mouth Dissolving Tablets: Development of Formulas and Invitro Evaluation
Abstract: Pharma Burst ODT super disintegrants were used in different concentrations to manufacture Zolmitriptan fast dissolving tablets by a direct compression method. With a 28° angle of repose, there is good flow. The densities for bulk and tapped materials are 0.410 (g/ml) and 0.500 (g/ml), respectively. The compressibility index and Hausner ratio have values of 19.05 and 1.24, correspondingly. According to IP standard, weight variation test results range from 121.4 mg …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 1–15 Read article
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Interplay of Thyroid Dynamics in Type 2 Diabetes: A Comprehensive Analytical Study at Government Medical College, Kota, and Affiliated Hospitals
Abstract: Diabetes mellitus is a prevalent endocrine metabolic condition that causes significant morbidity and mortality globally. Innumerable metabolic processes within our bodies depend on thyroid hormones. Excess or deficiency in insulin or thyroid hormones might cause functional problems. The intricate relationship between thyroid disorders and diabetes has been recognized for a considerable period. Patients with diabetes have been known to experience thyroid malfunction, the most prevalent kind of which is hypothyroidism. …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 1, 2024 · pp. 6–11 Read article
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Comparative Study to Assess the Knowledge of Higher Secondary School Students Regarding Career Counselling in Selected Rural and Urban Schools of Kashmir
Abstract: Background: Career counseling assists individuals in choosing appropriate educational and occupational choices and making career options based on future employment demands and requirements. Career counseling comprises a wide variety of professional activities that assist people in overcoming career-related obstacles. Aim: The primary objective of the study was to evaluate the understanding of career counseling among students in chosen rural and urban high schools in Kashmir. Method: This study employed a …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 1, 2024 · pp. 11–18 Read article
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EXPERIMENTAL STUDY ON REPLACEMENT OF CEMENT AND FINE AGGREGATE WITH MARBLE DUST AND COPPER SLAG
Abstract: With the ever-growing challenge of managing escalating waste materials globally, this paper explores sustainable solutions in construction through the utilization of marble dust and copper slag. The rapid generation of waste poses severe environmental and health threats, necessitating innovative strategies for responsible waste management. Local availability and the potential to enhance concrete strength make marble dust and copper slag attractive candidates for the partial replacement of cement and fine aggregate. …
Published in Journal of Polymer & Composites · Vol. 12, Issue 1, 2024 · pp. 169–176 Read article
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A Study of Trends in Healthcare Spending in India
Abstract: The total health services expenditure in India over a year has been pegged at 3.6% of GDP while the average person has to spend as much as 9,373 health expenses during the period, resulting in high costs on health services. About 3.2% of Indians fall below the poverty line by selling their wealth. Statistical data has been obtained and studied here from the reports of WHO, NHA and World Bank. …
Published in Research and Reviews: A Journal of Health Professions · Vol. 14, Issue 1, 2024 · pp. 24–28 Read article
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Uterine Leiomyosarcoma: A Diagnostic Dilemma
Abstract: Tumours that fall under the category of uterine malignancies include carcinosarcomas, leiomyosarcomas, endometrial stromal sarcomas, and undifferentiated sarcomas. Of them, leiomyosarcoma is the most common subtype, while still quite uncommon—it accounts for 1% to 2% of uterine cancers. Since postmenopausal bleeding is typically present in leiomyosarcomas, prompt detection is essential for successful treatment. This case study features a 50-year-old female patient who had postmenopausal bleeding, which is a common sign …
Published in International Journal of Pathogens · Vol. 1, Issue 1, 2024 · pp. 38–42 Read article
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Advancements in Smart Home Technology: Evoview’s Impact and Reflection
Abstract: The “EvoView” project is a sophisticated blend of design and technology, featuring RaspberryPi 4, a sleek display panel, a meticulously crafted wooden frame, and a one-way glass mirror. This innovative mirror transforms into an information hub, displaying real-time weather updates, current time, news, and upcoming events seamlessly. A strategic decision was made when the Raspberry Pi 3 Plus 4 was selected as the project's central processing unit. This option allows …
Published in Journal of Instrumentation Technology & Innovations · Vol. 14, Issue 1, 2024 · pp. 16–21 Read article