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92 articles for “toxicological effects”
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Evaluation for Diuretic Activity of Abutilon indicum and Amaranthus spinusus Leaves Extracts
Abstract: The diuretic activity of Abutilon indicum and Amaranthus spinusus leaves was studied. The fractions of ethanol and methanol showed significant increase in the urine elimination, while ethyl acetate fraction does not show diuretic activity. All the groups were compared to the control group; frusemide was used as reference standard drug in this screening activity. The phytochemical screening study showed the presence of flavonoids, saponins, terpenoids, and steroid content in both …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 2, 2017 · pp. 12–15 Read article
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Selenium Contamination of Groundwater of Malwa Belt of Punjab (India)
Abstract: Punjab is facing a crisis situation due to high levels of uranium, arsenic and selenium in underground water table of Punjab. Malwa belt of Punjab, namely, Ludhiana, Ferozepur, Roop Nagar and Fatehgarh sahib districts have high selenium contents in groundwater. Selenium Acceptable Limit (AL) for groundwater is fixed at 0.01 mg/l (ppm) by the Bureau of Indian Standards (BIS). In this report, groundwater quality data pertaining to selenium in the …
Published in Research and Reviews: A Journal of Toxicology · Vol. 9, Issue 1, 2019 · pp. 13–20 Read article
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Selenium Contamination of Groundwater of Doaba Belt of Punjab (India)
Abstract: Punjab is facing a crisis situation due to high levels of uranium, arsenic and selenium in underground water table of Punjab. Doaba belt of Punjab, namely, Jallandhar, Kapurthala and Hoshiarpur districts have high selenium contents in groundwater. Selenium Acceptable limit (AL) for groundwater is fixed at 0.01 mg/l (ppm) by the Bureau of Indian Standards (BIS). In this report, groundwater quality data pertaining to selenium in the Doaba belt is …
Published in Research and Reviews: A Journal of Toxicology · Vol. 9, Issue 1, 2019 · pp. 1–8 Read article
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Toxicological Examination of Dopamine's Involvement in Substance Abuse: An Overview
Abstract: Dopamine, classified as a catecholamine, is an essential organic compound that plays a crucial role in the brain's reward system and regulatory processes. It is instrumental in reinforcing pleasurable activities through repeated engagement. Acting as a neurotransmitter, dopamine is released in various brain regions, including the striatum and accumbens, and is absorbed by neurons through receptors.This review aims to comprehensively outline the mechanisms of dopamine release and its pivotal role …
Published in Research and Reviews: A Journal of Toxicology · Vol. 13, Issue 3, 2023 · pp. 22–25 Read article
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Phytopharmacognostic Study Development And Assessment Of Datura Stramonium
Abstract: Daturastrontium, a member of the Solanaceae family, is widely known for its medicinal and toxicological significance. Native to Asia and the Americas, it has been utilized for both spiritual rituals and traditional medicine due to its potent psychoactive and narcotic properties. Historically, it has been employed to treat conditions such as asthma, rheumatism, and inflammation, but its misuse, especially in religious contexts and recreationally, often leads to toxic effects like …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 33–39 Read article
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article
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Medico-legal Autopsy in Evidencing of Homicide: Issues and Challenges
Abstract: The project attempts to study issues and challenges that arise during a medico-legal autopsy and the consequential medical evidence by post-mortem surgeon in court of law. The research methodology which has been used is doctrinal in nature. Primary and secondary sources have been used in the study. The primary data has been collected from the judgments of Supreme Court, High courts, various enacted laws and reports of the Law Commission …
Published in Research and Reviews: A Journal of Toxicology · Vol. 9, Issue 2, 2019 · pp. 36–42 Read article
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Chromosomal Aberration and Mutagenicity Toxicological Studies of Beta-Sitosterol Isolated from Ocimum gratissimum (Lamiaceae)
Abstract: Ocimum gratissimum is an important medicinal plant belonging to the Lamiaceae family. Ocimum gratissimum is a small erect or straggling tree or large, woody, climbing shrub found almost throughout India including Andaman and Nicobar Islands. Stem have been used in antifertility treatment in the indigenous system of medicine, and further clinical tests substantiated their efficacy. The root bark contains diketones, fatty matter, rubber, dulcitol, Beta-sitosterol, phlobatannin and glycosidal tannins. Stem …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 4, Issue 2, 2017 · pp. 1–6 Read article
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Studies on acute toxicity and behavioral responses of Heteropneustes fossilis (Linn.) exposed to Diazinon
Abstract: In the present study, acute toxicity of the organophosphate pesticide, diazinon, was evaluated under experimental condition to adult Heteropneustes fossilis. The 96 h LC50 with 95% confidence limits of Heteropneustes fossilis is 16.56 (14.32- 18.04) mg/l. None of the unexposed control fish died during the experiment. Mortality rate between each dose and mortality rate between 24-96 h depending on time was correlated. In the fish, significant relationship (p<0.05) was recorded …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 1, 2018 · pp. 9–13 Read article
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Protective Role of Sulforaphane against Multiorgan Toxicity in Rats: An In-vivo and In-vitro Review Study
Abstract: Sulforaphane [1-isothiocyanate-(4R) -(methylsulfinyl) butane] is a natural dietary isothiocyanate produced by the enzymatic accomplishment of the myrosinase on glucopharanin, a 4-methylsulfinylbutyl glucosinolate contained in cruciferous vegetables such as broccoli, brussel sprouts, and cabbage. Exploring of this compound against various oxidative degenerative diseases such as hepatic, nephro and cardiac diseases is growing because of its anticarcinogenic and cytoprotective properties. In several invivo and invitro experimental paradigms proved SFN and its compounds …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 1, 2018 · pp. 1–8 Read article
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A Preliminary Report on Groundwater Contamination of Majha Belt of Punjab due to Heavy Metal Arsenic
Abstract: Punjab is facing a crisis situation due to high levels of heavy metals in underground water table of Punjab. ICAR has reported arsenic beyond safe limit in 13 districts of Punjab. According to PWSSD report, there are 2748 habitations out of 6884 surveyed in Punjab, which fall under quality affected (QA) category (40% nearly). Out of all QA habitations in Punjab, 60% fall in Majha belt of Punjab, namely, Amritsar, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 3, 2017 · pp. 27–33 Read article
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Vyanga, Present-Day Challenge: Insights from Toxicological Standpoint
Abstract: The condition of Vyanga can have significant repercussions, as facial disfigurement not only impacts an individual's psychological and social well- being but also hampers their overall contribution to society. This can result in reduced productivity, impaired social functioning, and diminished self-esteem. In classical Ayurvedic texts, Vyanga is categorized under Kshudrarogas, representing minor disorders with straightforward causes and symptoms. However, in certain instances, these conditions can lead to noticeable cosmetic impairments, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 11–16 Read article
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Various Aging Factors and Their Significant Impacts on the Skin
Abstract: As the average lifespan in developed nations rises, proper aged skin care has become a dermatological concern. The complicated, multifaceted process of skin aging has a genetically established baseline pace but can also be sped up by socioeconomic, mechanical, or environmental variables. Skin fragility, skin resiliency, the danger of toxicological injuries, the promotion of the development of different cutaneous illnesses, and aesthetically unfavorable consequences like wrinkles and uneven pigmentation are …
Published in Research and Reviews: A Journal of Health Professions · Vol. 13, Issue 1, 2023 · pp. 1–10 Read article
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A Comparative Review on Abelmoschus palianus and Barleria mysorensis: Phytochemical Constituents, Pharmacological Potentials, and Ethnobotanical Significance
Abstract: Medicinal plants have long served as invaluable resources for treating human ailments, with countless species still awaiting scientific exploration and validation. Abelmoschus palianus and Barleria mysorensis are two such botanicals with rich ethnomedicinal heritage but limited pharmacological characterization. This review presents a detailed comparative analysis of these two species, examining their botanical descriptions, geographic distribution, traditional applications, phytochemical constituents, pharmacological properties, toxicological profiles, and therapeutic potential. Abelmoschus palianus, native to …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 3, 2025 · pp. 7–13 Read article
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Metal Complexes of Cephalexin and Their Biological Activities: A Review
Abstract: Cephalexin and its derivatives are commonly utilized in the pharmaceutical and medicinal industry due to their biological and pharmaceutical activities, including anti-microbial, anti-cancer, anti-bacterial, and herbicidal activities as well as possessing high palatability and being useful for skin and joint infections. Interestingly, some organic drugs, including cephalexin, which exhibit toxicological and pharmacological properties, can be administered in forms of metal complexes. Many researchers have synthesized organic ligands derived from cephalexin …
Published in Journal of Polymer & Composites · Vol. 11, Issue 2, 2023 · pp. 52–61 Read article
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Attenuation of Doxorubicin-induced Hepato- and Nephrotoxicity by Proanthocyanidins from Myrica nagi Bark in Wistar Rats
Abstract: Due to dose-related toxic effects, doxorubicin, a very potent and often used anti-cancer medication, is largely limited. The current research investigated the protective impact of Myrica nagi bark (PMN)-isolated proanthocyanidins on hepato-induced doxorubicin and nephrotoxicity in Wistar rats. The animals were subdivided into six classes of five rats each. Group I got PMN (200 mg/kg, p.o.) for 21 days, Group II received Doxorubicin (DXR) (60 mg/kg, i.p.) once, 48 h …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 3, 2020 · pp. 19–28 Read article
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Antibacterial, Cytotoxicity Studies of Azukia mungo (L.) Masam and Correlation with in silico Docking Studies
Abstract: Introduction and Background: Azukia genus plants rich in proteinaceous anti-nutrients like tannins (especially condensed tannins) has been shown to have anti-bacterial activity against Staphylococcus aureus and antineoplastic activity against lung and liver cancer cells. Five types of procyanidins (condensed tannins) have already been isolated from Azukia mungo and structurally elucidated. But its activity against the Methicillin resistant Staphylococcus aureus (MRSA) has not yet been shown. Hence we focus our work …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 2, 2017 · pp. 21–31 Read article
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Gossypetin Inhibits ROS Generation in HeLa and HepG2 Cell Lines
Abstract: Antioxidants are known for their ability to neutralize the reactive oxygen species present within the living system. These antioxidants are mainly secondary metabolites present in plant products and are generally known as nutraceuticals or bioactive compounds. Antioxidant can be categorized into many categories based upon their structure and activities like flavonoids, anthrocyanins and carotenoids. Flavonoids are heterogeneous polyphenolic compounds having beneficiary effect on human body and are also known to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 25–31 Read article
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Food Packaging Chemicals and Human Health: Molecular Toxicity, Exposure Pathways, and Regulatory Perspectives
Abstract: Food packaging plays a vital role in preserving food quality, extending shelf life, and ensuring safe transportation. However, increasing evidence indicates that chemicals from packaging materials can migrate into food during processing, storage, and consumption, resulting in chronic human exposure. Several food packaging chemicals, including bisphenols, phthalates, per- and polyfluoroalkyl substances (PFAS), styrene, heavy metals, and non-intentionally added substances (NIAS), have emerged as important xenobiotics due to their potential adverse …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 Read article
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Groundwater Contamination in Punjab due to Arsenic, Selenium and Uranium Heavy Metals
Abstract: Punjab is facing a crisis situation due to high levels of heavy metals in underground water table of Punjab. ICAR has reported arsenic beyond safe limit in 13 districts of Punjab. According to PWSSD report, out of all arsenic contaminated habitations in Punjab, 60% fall in Majha belt of Punjab, namely, Amritsar, Gurdaspur and Tarn Taran districts. Arsenic contamination can be get rid of by using a nanotechnology based technique …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 1, 2020 · pp. 1–7 Read article