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71 articles for “Genomic Analysis”
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Pathophysiology Reimagined: Integrating Systems Biology and AI for Disease Understanding
Abstract: Pathophysiology, the study of disease mechanisms at molecular, cellular, and systemic levels, has traditionally relied on reductionist approaches that often fail to capture the complex, dynamic, and interconnected nature of biological systems. Diseases such as cancer, neurodegenerative disorders, and infectious diseases arise from intricate interactions among genetic, epigenetic, metabolic, and environmental factors, necessitating integrative, data-driven methodologies for a deeper understanding. Systems biology has emerged as a powerful approach by leveraging …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 63–71 Read article
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Molecular Evolution of Virulence Genes of Coronavirus: A Computational Study
Abstract: Corona Virus i.e., Covid 19 is consider as highly pathogenic and transmissible, which is responsible for emerging scenario of current pandemic disease. The family of this virus Coronaviridae, which affect respiratory system of human along with animal, and It is belived to be originated from bat. The homology of covid 19 is mix of SARA-CoV and MERS-CoV. The Single-stranded positive genomic RNA, which is coated by nucleocapsid protein is present …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 2, 2021 · pp. 22–35 Read article
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An Outbreak of Massive Crisis of the Attack of Current Novel Coronavirus
Abstract: A cluster of cases of pneumonia of unknown cause was detected in Wuhan City, Hubei Province of China on 31 December 2019 was informed by WHO. Chinese authorities identified the causative virus of coronavirus disease (COVID-2019) on 7th January 2020. During the first 2 months of the current outbreak, COVID-19 an epidemic disease spread rapidly throughout China and caused varying degrees of illness. It was observed that 2019- nCoV is …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 10, Issue 2, 2020 · pp. 1–9 Read article
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A Review of Recent Advancements in Machine Learning and Deep Learning Approaches for Pet Diseases Prediction
Abstract: This systematic study assesses recent developments in Machine Learning (ML) and Deep Learning (DL) approaches to predict pet diseases. With the increasing role of Artificial Intelligence (AI) in pet healthcare, this study identifies recent research trends, limitations, and future directions. A comprehensive search was done using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines in selecting 20 relevant studies from over 300 articles published between 2020 and …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 3, 2025 · pp. 1–6 Read article
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A Molecular Docking Study: Targetting HIV-1 Integrase Protein Against Selected Phytocompounds from Calophyllum Lanigerum
Abstract: Objectives: The most common form of HIV that causes AIDS is HIV-1. The World Health Organization has estimated roughly 75 million plus HIV-1 infections till date and roughly 40 million deaths (as of 2021). Thus, this study was done to identify natural compounds from Calophyllum lanigerum, a medicinal plant largely endemic to South-East Asia, to inhibit the spread of this disease. It did so by using molecular docking methods, Lipinski …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 43–55 Read article
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 · pp. 15–22 Read article
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Exploring Phytochemicals of Ficus religiosa against Corona Virus Protein using Molecular Modeling Techniques
Abstract: The current worst pandemic situation is brought about by novel Severe acute respiratory syndrome coronavirus 2 causing Covid-19 disease. The world fights against it with vaccines, self-sanitation techniques and drugs like ribavirin, beta-interferon and remdesivir which has not solved the problem to the desired extent. With technical and scientific developments in molecular biology field, though the genome and proteome of the organism is explored, potent drugs against it is still …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 2, 2023 · pp. 18–26 Read article
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Applications of computational techniques in Gene advancements
Abstract: Deep Learning as well as Advanced Analytics could perhaps assist in controlling the massive, unexpected volume of information obtained from screening programs, legitimate pandemic outbreak scanning, pattern prediction, routine condition checklist as well as upgrading from regulatory establishments or species, or rather medical equipment utilization facts, subsequent breakthroughs of genomic as well as bioinformatics methodologies or data exchange systems. The purpose of this article is to provide a insight of …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 9, Issue 1, 2022 · pp. 1–8 Read article
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Modernizing Pharmacovigilance: Leveraging AI,Automation, and Real-World Data for Drug Safety
Abstract: Pharmacovigilance, or PV, is “the pharmacological science relating to the detection, assessment, understanding, and prevention of adverse effects, mainly long term and short-term adverse effects of medicines.” PV’s specific objectives are to increase patient care and safety when using medications and all medical and paramedical therapies; assist in evaluating the benefits, drawbacks, efficacy, and risks of medications, ensuring their safe, prudent, and more effective use; and promote clinical training, education, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 1, 2026 · pp. 21–30 Read article
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Designing Mithun Specific Probes Towards Development of Microarray for Mithun (Bos frontalis)
Abstract: cDNA microarrays are powerful tools to analyze the expression pattern of thousands of genes simultaneously in response to treatments, during tissue differentiation or related to differences in traits. To get accurate results, the probes used in the microarray are to be specific to the species for which the array is being conducted. Non-availability of suitable microarray specific to mithun (Bos frontalis), a rare ruminant of Southeast Asia, limits its use …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 4, Issue 3, 2015 · pp. 1–7 Read article
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Advances in Diagnostic Techniques in Veterinary Medicine
Abstract: Diagnostic techniques play a crucial role in veterinary medicine for accurate disease identification, treatment planning, and monitoring of animal health. This review article explores the latest advancements in diagnostic tools and technologies used in veterinary medicine, focusing on imaging modalities, molecular diagnostics, and point-of-care testing. The first section discusses the advancements in imaging modalities, including digital radiography, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography. These technologies have revolutionized …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 12, Issue 1, 2023 · pp. 1–4 Read article