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97 articles for “Clinical translation”
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Modulation of Receptor Proteins: A Recent Paradigm in Drug Discovery and Target
Abstract: The main aim in drug discovery is to design different ligands those work on specific drug targets. However, various effective drugs work through the modulation of many proteins than single target. Advancement in system biology are establishing a phenotypic strength and a network structure, which suggests that, the excellent selective compounds may be performed less than desired clinical efficacy in comparison to multi-target drugs. In this new appreciation of the …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 14–24 Read article
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Explainable Artificial Intelligence in Personalized Medicine: Emerging Clinical Perspectives
Abstract: The convergence of artificial intelligence (AI) and precision medicine has transformed contemporary healthcare by enabling data-driven clinical decision-making, individualized therapeutic interventions, and predictive diagnostics. However, despite remarkable advances in machine learning (ML) and deep learning (DL), the widespread adoption of AI in healthcare remains constrained by the “black-box” nature of many computational systems. Clinicians, regulatory agencies, and patients increasingly demand transparency, interpretability, and trustworthiness in AI-guided medical recommendations. Explainable Artificial …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 · pp. 13–29 Read article
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Advancing Gene Therapy: Next-Generation Viral Vector Engineering for Precision, Safety, and Scalability
Abstract: Gene therapy has emerged as a paradigm-shifting modality for the treatment of genetic disorders, malignancies, and rare diseases through the delivery of therapeutic nucleic acids aimed at correcting or modulating dysfunctional gene expression. Among the various delivery systems, viral vectors including adeno-associated viruses (AAVs), lentiviruses, adenoviruses, retroviruses, and herpes simplex viruses have proven indispensable owing to their high transduction efficiencies and adaptability. This review offers a comprehensive assessment of viral …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 37–55 Read article
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Recent Advances in Nanobiotechnology: Applications and Future Perspectives
Abstract: Nanobiotechnology is a rapidly growing field that combines the principles of nanotechnology with biology, medicine, and biotechnology. This review article provides an overview of recent advances in nanobiotechnology and their applications in various fields, including drug delivery, imaging, biosensors, tissue engineering, and nanomedicine. The article also discusses the challenges and future prospects of nanobiotechnology. This review article provides an overview of recent advances in nanobiotechnology and their applications in various …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 24, Issue 3, 2022 · pp. 43–47 Read article
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Host-Pathogen Coevolution: Implications for Immune Evasion and Pathogen Fitness
Abstract: The interaction between hosts and pathogens represents a continuous evolutionary struggle, shaping both microbial virulence and host immunity. Pathogens employ diverse strategies to evade immune surveillance, ranging from antigenic variation and molecular mimicry to hijacking of host immune checkpoints. Simultaneously, hosts refine innate and adaptive immune mechanisms to counteract infection and limit damage. This reciprocal adaptation, known as host–pathogen coevolution, influences pathogen persistence, transmission, and fitness, while also sculpting immune …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 6–10 Read article
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Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: The interaction between hosts and pathogens represents a continuous evolutionary struggle, shaping both microbial virulence and host immunity. Pathogens employ diverse strategies to evade immune surveillance, ranging from antigenic variation and molecular mimicry to hijacking of host immune checkpoints. Simultaneously, hosts refine innate and adaptive immune mechanisms to counteract infection and limit damage. This reciprocal adaptation, known as host–pathogen coevolution, influences pathogen persistence, transmission, and fitness, while also sculpting immune …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 Read article
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The Intelligibility in Context Scale in Tamil—Reliability and Validity Measures
Abstract: Objective: The Intelligibility in Context Scale (ICS) was originally developed by Sharynne McLeod, Linda J. Harrison and Jane McCormack in 2012. It is a 7 item parent-rated questionnaire designed to assess speech intelligibility in very young children using a quantitative score out of 5. It is intended to supplement other clinical measures of speech intelligibility in providing a comprehensive picture of the speech of children with several speech impairments (speech …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 8, Issue 3, 2019 · pp. 16–21 Read article
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Advancing Cancer Vaccine Development through CRISPR/Cas9 Technologies and Future Opportunities
Abstract: The advent of CRISPR/Cas9 genome editing has revolutionized the cancer immunotherapy market, offering unprecedented precision and versatility in the development of next-generation cancer vaccines. This review examines how CRISPR technologies are being integrated into various stages of cancer vaccine development including neoantigen discovery, dendritic cell engineering, cancer cell reprogramming, and tumor microenvironment modulation. In the area of neoantigen discovery, CRISPR enables rapid identification and validation of tumor-specific mutations, thereby supporting …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 Read article
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Advances in Polymer Chemistry for Coronary Artery Disease
Abstract: Coronary artery disease (CAD) remains the leading cause of morbidity and mortality worldwide, driving ongoing innovation in therapeutic materials and device design. Polymer chemistry has emerged as a cornerstone in the development of advanced cardiovascular interventions, offering versatile platforms to improve the safety, efficacy, and functionality of implantable devices. This review explores recent advances in the synthesis and application of biodegradable and biostable polymers, focusing on their roles in drug-eluting …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 710–716 Read article
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Quorum Sensing and Biofilm Dynamics in Pathogens: An Evolving Frontier in Infectious Disease
Abstract: Bacterial and fungal pathogens rarely act as solitary invaders. Instead, they engage in sophisticated chemical communication known as quorum sensing (QS) to coordinate population-wide behaviours and construct structured, multicellular biofilm communities. These biofilms, composed of extracellular polymeric substances, not only facilitate microbial persistence on biotic and abiotic surfaces but also confer remarkable protection against host immune defenses and antimicrobial therapies. QS systems act as central regulators of biofilm dynamics, orchestrating …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 18–23 Read article
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Concept of Qillat-I-Darqiyat (Hypothyroidism) in Unani System of Medicine: A Systemic Review
Abstract: All types of sue-i-mizaj have their specific consequences and effects on every tissue of the human body. The clinical features of Sue-i-Mizaj Baridratab are nearly similar to that Hypothyroidism, which translated as Qillat-i-Darqiyyat in Unani system of medicine. Amongst all the endocrine disorders, Hypothyroidism is the most common and usually affects females. The lifetime risk of thyroid disorder in women is one in eight. In India 42 million people suffer …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 9, Issue 2, 2020 · pp. 21–28 Read article
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A Study of Optical Sensor in Clinical applications
Abstract: The escalating demand for precise, real-time, and minimally invasive diagnostic and monitoring tools in clinical practice has propelled the development of sophisticated sensor technologies. Among these, optical sensors have emerged as a cornerstone, leveraging the interaction of light with biological matter to translate molecular or cellular events into quantifiable signals. Their inherent advantages – including high sensitivity, specificity, rapid response times, non-ionizing nature, and potential for miniaturization – make them …
Published in International Journal of Optical Innovations & Research · Vol. 3, Issue 2, 2025 · pp. 1–7 Read article
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Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 · pp. 47–58 Read article
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Systematic Analysis of the Pharmacological Properties of Different Plant Parts of Madhuca sp.
Abstract: Madhuca sp., a perennial tree belonging to the Sapotaceae family, is widely distributed across South and Southeast Asia. It holds considerable value across the food, beverage, and pharmaceutical sectors. The growing interest among cultivators, agronomists, and industry stakeholders stems from the diverse bioactive potential documented across different parts of the plant, including the bark, leaves, seeds, and flowers. Traditional and emerging evidence points to a wide spectrum of pharmacological actions, …
Published in Research & Reviews : Journal of Botany · Vol. 15, Issue 2, 2026 · pp. 1–11 Read article
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India’s Pioneering Advancements in Vaccinology: Challenges and Milestones – Part 2
Abstract: India has become a global leader in vaccinology, playing a vital role in developing, producing, and distributing vaccines that protect millions of lives. By embracing advances in molecular immunology, recombinant antigen technology, and virus-like particle (VLP) platforms, the country has created affordable vaccines against major diseases, including poliovirus, rotavirus, and SARS-CoV-2. National initiatives, like Mission Indradhanush and Vaccine Maitri, have helped expand immunization coverage, improve public health, and share vaccines …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 2, 2026 · pp. 1–21 Read article
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A Standards-Compliant API Framework for Integrating NAMASTE and ICD-11 TM2 Terminologies into Indian Electronic Medical Records (EMRs)
Abstract: The lack of standardized, interoperable terminology services has hindered the integration of India’s traditional medical systems into the mainstream digital health infrastructure. Although ICD-11 Traditional Medicine Module 2 (TM2) offers an internationally harmonized classification for traditional medicine diagnoses and the NAMASTE portal defines structured vocabularies for AYUSH conditions, current Electronic Medical Record (EMR) platforms in India are unable to natively consume, map, or translate these terminologies in a way that …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 2, 2026 · pp. 19–27 Read article
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Current Issues in Understanding of Diabetes
Abstract: Diabetes mellitus is a significant metabolic disorder that poses a major health concern, particularly in India. India harbours the world's highest number of diabetic patients, totalling around 130 million, with an additional 40 million categorised as prediabetic. In the global context, the number of adults suffering from diabetes was roughly 150 million in 2000, but this number is projected to significantly increase by 2030. The global prevalence of prediabetes is …
Published in Research and Reviews: A Journal of Medicine · Vol. 13, Issue 2, 2023 · pp. 1–12 Read article
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Natural Language Processing in Everyday Applications: From Classrooms to Clinics
Abstract: Natural Language Processing (NLP) is transforming everyday sectors like healthcare and education by creating new opportunities for efficiency, accessibility, and early intervention. This paper investigates the function of natural language processing (NLP) in computer education. Tools like automated grading systems, intelligent tutoring assistants, and multilingual translation platforms are revolutionizing traditional teaching methods. Despite its benefits, adoption is still being slowed down by problems like data privacy, integration with education, and …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 3, 2025 Read article
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Sustainable Advances in Oral Pathology: The Impact of Artificial Intelligence
Abstract: Oral cavity cancers constitute about 4% of all malignant neoplasms. More than 9,900 new cases are reported from the developed countries yearly, and the 5-year mortality rate is higher than 39%. In Europe, the highest rates occur in Hungary, Croatia, and other Central and Eastern European countries; high levels are also seen in India, Pakistan, and Bangladesh. The management of endosseous pathologies presents considerable challenges because they often exhibit no …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 1, 2025 · pp. 24–27 Read article
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Artificial Intelligence for Tracking Cognitive Deviation in Aging Populations: A Comprehensive Review of Techniques, Challenges, and Ethical Concerns
Abstract: Population aging is accelerating worldwide, and with it the burden of cognitive health conditions such as mild cognitive impairment (MCI), Alzheimer’s disease (AD), and dementia. Detecting and monitoring cognitive change early is central to timely intervention, yet conventional diagnostic tools often miss the subtle signals that appear before overt symptoms. Artificial intelligence (AI) has emerged as a promising complement to clinical assessment because it can work through high-dimensional data and …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 16, Issue 2, 2026 · pp. 27–37 Read article