Search
1969 articles for “AFS” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
-
Exploring Pharmacological Mechanism Of Pteridines And Its Derivatives Against Neurodegenerative Disorders Using Network Pharmacology And Molecular Docking Techniques
Abstract: Objectives: Pteridines have been identified via various research and shown therapeutic efficacy in Neurodegenerative disorders(ND) preclinical models. In the current study, a network pharmacology technique was applied to determine the underlying mechanism of the pteridines' protective effects on ND. Network pharmacology was utilised in order to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 1–13 Read article
-
Molecular Docking of Compounds against Dengue Virus Serotype 2 and Prediction of ADME Properties Using Computational Approaches.
Abstract: Objective: Human lives are now seriously threatened by dengue fever, which is brought on by the dengue virus (DENV). It is well known that phytochemicals have a great deal of promise for curing human viral, bacterial, and fungal diseases. The purpose of this research was to develop drugs against the nonstructural protein (NS5) of dengue virus 2 (DENV2).Methods: Five phytochemicals from various medicinal plants were chosen for this research. The …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 1, 2023 · pp. 1–11 Read article
-
Soursop Phytocompounds as Potential Anticancer Agents: A Molecular Docking Study
Abstract: Objective: According to tumor statistics, there will be a total of approximately 1,958,310 new malignancy cases, that balances to nearly 5,370 cases day by day. Without any questions its clearly evident that cancer is considered as one of the deadliest diseases of mankind. The course of this study emphasizes on computational approach for finding new drug for potential target proteins Bcl-2 (4MAN) and Mcl-1(5FDO) by docking against soursop (Annona Muricata …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 18–39 Read article
-
Investigating Curcumin Phytocompounds as Prospective Parkinson's Disease Therapeutic Agents: A Computational Method that Targets LRRK2 Protein
Abstract: Objective: Parkinson’s Disease is the second stage predominant neurodegenerative illness. Primary aetiology is still unknown. One of the biggest battlegrounds in modern medicine is discovering the cause of Parkinson’s disease (PD), as well as the hunt for palliative treatments and, if feasible, a cure. The objective of this work is to identify the phytocompounds from curcumin (curcuma longa) for the treatment of PD. Curcumin, a well-researched phytochemical, has been suggested …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 55–67 Read article
-
The Patterns of Enamel Rod after Exposure to Probiotic Beverages
Abstract: Probiotic beverages have a taste of acid that is produced by fermentation of probiotic bacteria. The acid condition can affect the structure of tooth enamel. The structure of tooth enamel is formatted by enamel prism that is composed by hydroxyapatite (HA) crystals. According to several studies, HA has a critical pH <5.5 and can be changed in 180 min by acid. The objective of the study is to describe enamel …
Published in Research and Reviews: A Journal of Dentistry · Vol. 3, Issue 2, 2012 · pp. 28–36 Read article
-
Dental Fluorosis: A Review
Abstract: Fluoride is known to affect mineralized tissues of the body and, when consumed at greater than optimal levels, it disturbs the process of tooth and bone mineralization. Excessive consumption of fluoride can cause dental or skeletal fluorosis. Skeletal fluorosis is caused by consumption of much higher quantities of fluoride over extended periods and is a crippling disease characterized by severe bone deformities. On the other hand, dental fluorosis is much …
Published in Research and Reviews: A Journal of Dentistry · Vol. 12, Issue 2, 2021 · pp. 19–26 Read article
-
Assess the Mental Wellbeing of Girl Students with Demographic and Social Factor
Abstract: Girl students’ performance totally depends on their mental and physical strength. So, to assess the student’s mental health is noteworthy. The Warwick Edinburgh Mental well-being scale (WEMWBS) is a reliable and validated tool to assess the mental wellbeing of the students in India. This study aims to assess the WEMWBS and compare scale with the demographic and social factors in India. The convenient sampling method was used to assess WEMWBS …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 3, 2018 · pp. 6s–11s Read article
-
Genetic Testing: An Intervention of Biotechnology for Healthy Motherhood
Abstract: The journey from a woman to a mother had been one of the sweetest of its kind. Having a child with a chronic illness has a major impact on the family as a whole, especially mothers. Mothers of a child with chronic disease experience difficulties in dealing with feelings which may subsequently lead to a dysfunctional family. Usually parenting stress is more on mothers caused by having their more affectionate …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 3, 2018 · pp. 87s–90s Read article
-
Association of Disability and QOL in Physiotherapists Suffering from WRMSDs in Delhi and NCR
Abstract: Association of Disability and QOL in Physiotherapists Suffering from WRMSDs in Delhi and NCR. A survey study. All the subjects included were from various private hospitals and private clinics in Delhi and NCR. A total of 100 subjects were recruited for the study on the basis of inclusion and exclusion criteria after signing the informed consent form. The data regarding their musculoskeletal pain, disability and quality of life was taken …
Published in Research and Reviews: A Journal of Health Professions · Vol. 4, Issue 2, 2014 · pp. 7–12 Read article
-
Study of Polycystic Ovary Syndrome (PCOS) with Special Reference to Candidate Genes
Abstract: The PCOS (polycystic ovary syndrome) has become a worldwide concern as progression of PCOS in the age group of adolescence to postmenopausal women is increasing. In India, sudden rapid growth in PCOS is observed in the range of 3.7–22.5%. Effects of PCOS are not only on the reproductive and metabolic systems, but the whole body’s metabolism gets affected; ultimately, it leads to different life- style diseases like type 2 diabetes …
Published in Research and Reviews: A Journal of Health Professions · Vol. 13, Issue 1, 2023 · pp. 49–55 Read article
-
Immunomodulation in Viral Infections
Abstract: Several studies conducted over a period of two decades established that hypothalamic-pituitary-adrenocortical axis is activated during systemic viral diseases. Modulation of the Th1/Th2 balance may affect the susceptibility to or the course of infections. Reduction of T and B lymphocytes are reported during influenza virus infection. This modulation leads to limited immune response. The brain areas involved in the regulation of hypothalamic-pituitary-adrenocortical axis are affected during viral infection. Human immunodeficiency …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 5–8 Read article
-
Prevalence of HIV Associated Neuro-cognitive Deficit among HIV Positive People in Ethiopia: A Cross Sectional Study at Hawassa University Comprehensive Specialized Hospital
Abstract: Background: HIV/AIDS is a common infection in sub-Saharan Africa which is also associated with neurocognitive impairment and psychological. Even if HAART reduces HIV-associated neurocognitive disorders (HAND) by approximately 60 percentage, over 8 million HIV-infected adults in sub-Saharan Africa will be cognitively impaired at some level. This study aimed to assess prevalence and factors associated with neurocognitive impairment among adults living with HIV/AIDS at Hawassa University comprehensive specialized hospital, Ethiopia. Methods: …
Published in Research and Reviews : A Journal of Immunology · Vol. 8, Issue 3, 2018 · pp. 13–18 Read article
-
Compliance of Animal Bite Patients Managed by Intramuscular Route of Anti-rabies Vaccination
Abstract: Rabies, a zoonotic disease, is one of the oldest diseases affecting humans. Intramuscular anti-rabies vaccination (ARV) has been the mainstay of management of postanimal bites for rabies. This prospective study was conducted at ARV Clinic of the District hospital (Jamnabai Hospital), Vadodara to know the compliance of animal bite patients managed by intramuscular route of ARV and the reasons for delay or missing the Scheduled dosage of the same. Out …
Published in Research and Reviews : A Journal of Immunology · Vol. 4, Issue 2, 2014 · pp. 1–7 Read article
-
Over Expression of Genes at Long Arm of 21 Chromosome in Case of Down Syndrome
Abstract: Down Syndrome (DS) is a genetic disorder which is caused due to trisomy at chromosome 21 or gene dosage imbalance. DS leads to mental retardation in humans. It is a multisystem disorder as it affects several systems of our body like cardiovascular, respiratory, gastrointestinal, neurological, hematopoietic and musculoskeletal system. The principal cause of DS is unknown yet. Some factors are responsible for DS. like reproduction at advanced maternal age, folic …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 2, 2015 · pp. 27–34 Read article
-
Client Satisfaction and its Associated Factors towards Maternal and Child Health Services in Mekelle Health Centers, Ethiopia, 2015
Abstract: The health of the mother and child constitutes one of the most serious health problems affecting the community, particularly in the developing countries. Client satisfaction is fundamental for further improvement of quality of health care delivery system in general and maternal and child health care services in particular. However, studies on the level of client satisfaction with maternal and child health care service are lacking. So, the purpose of this …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 1, 2016 · pp. 1–5 Read article
-
Speech Profile of Myasthenia Gravis: Case Study
Abstract: Complex coordination in muscles of articulation was supported by number of separate neural events which is large and with an amazing degree of neural integration in motor system [1]. If any point along the pathway from the cerebrum to the muscle gets damage, then the motor system which controls the speech production may be spotted [1]. Difficulty in controlling the muscles responsible for speech is called Dysarthria. Mixed dysarthria, is …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 2, 2019 · pp. 11–13 Read article
-
Ethnomedicinal Plants Used in the Treatment of Asthma by Indigenous People of Ranchi District of Jharkhand
Abstract: This paper enumerates the traditional uses of 10 plant species belonging to few genera representing nine families, which are used by the village communities of Oraon, Munda, Mahato, Santhal, Birhor and Sadri of Ranchi district of Jharkhand for the treatment of asthma. Asthma is a condition of attacks, difficult breathing and breathlessness due to the contraction of air tubes and accumulation of mucus. It is a fatal disease that affects …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 3, 2019 · pp. 7–11 Read article
-
Prevalence of Lower back pain in a sample population of Musculo-skeletal disorders - Cross sectional community based study
Abstract: Musculoskeletal Disorders (MSD) is a global term for several types of disorders affecting the body’s joints, ligaments, muscles, nerves, tendons and structures that support limbs, neck and back. Low back pain (LBP) is most common musculoskeletal disorder defined as pain and discomfort, localised below the costal margin and above the inferior gluteal folds, with or without referred leg pain.LBP is one of the most common conditions encountered in clinical medicine.LBP …
Published in Research and Reviews: A Journal of Medicine · Vol. 11, Issue 2, 2021 · pp. 38–44 Read article
-
Review on Histological and Functional Effect of Alcohol on Liver and Kidney
Abstract: Alcohol consumption represents the third largest risk factor for disease burden in most countries of the world. The purpose of this review is to give a comprehensive report of the existing data on the potential adverse effects of alcohol on liver and kidney toxicity. We used 82 different published materials for the compilation of this review article. The Google search engine was used for accessing published materials from databases like …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 7, Issue 2, 2018 · pp. 49–62 Read article
-
Prevalence and Associated Factors of Attention Deficit Hyperactivity Disorder in School Age Children in Mekelle, Tigray, North Ethiopia, 2017
Abstract: Introduction: Attention-Deficit Hyperactivity Disorder is a neuron developmental disorder. African children are affected with this disorder which rates from 5.4 to 8.7%. This study aimed to assess the prevalence of attention-deficit hyperactivity disorder and its associated factors among school age children at Mekelle city, Tigray, Ethiopia, 2016/17. Method: Cross-sectional survey among 541 children at randomly selected institution was conducted between December 2016 and May 2017. Data were collected using structured …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 7, Issue 2, 2018 · pp. 21–34 Read article