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494 articles for “Validation Study”
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An Experimental Investigation of Process Parameters for Aluminum Alloy Composites
Abstract: The objectives of this work are to develop an aluminum alloy composites and investigate machining process parameters effect on the tool wear rate for composites. The composite is enhanced using silicon carbide and graphite. The composite is made by a method called stir casting. Furthermore, it is investigated both mathematically and experimentally. This study takes trial on aluminum alloy composite to see output characteristics tool wear rate are affected by …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 185–193 Read article
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Effect of the Integrated Approach to Yoga Therapy on Stress-Related Anxiety Disorder of a Roller Skater
Abstract: Anxiety and stress are common problems for competitive skaters, which frequently impairs their performance and general health. The Integrated Approach to Yoga Therapy (IAYT) offers a holistic intervention, addressing the physical, mental, and emotional dimensions of health. This study investigates the impact of IAYT on stress-related anxiety disorders in skaters, incorporating yoga postures (asanas), breathing techniques (pranayama), meditation, and relaxation practices. An 8-week intervention was conducted with 30 competitive skaters …
Published in Recent Trends in Sports · Vol. 2, Issue 1, 2025 · pp. 7–13 Read article
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Multi-Objective Optimization of Polymer-Based Functionally Graded Composites for Lightweight Structures
Abstract: Functionally graded composites (FGCs) improve lightweight structural performance by allowing material properties to change smoothly across a component. Polymer-based FGCs (P-FGCs), in particular, are gaining prominence in aerospace, automotive, and biomedical industries due to their excellent strength-to-weight ratio, tunability, and ease of processing. However, optimizing these materials for lightweight structural applications requires addressing conflicting design objectives, such as maximizing stiffness while minimizing weight or enhancing thermal resistance while maintaining manufacturability. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 961–973 Read article
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Identification of Promising Lead Compounds from Capsicum annuum Targeting BACE-1 for Alzheimer’s Disease Therapy: A Molecular Docking Study
Abstract: Background: Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions of people worldwide. Beta-secretase 1 (BACE-1) is an important therapeutic target for AD treatment. Capsicum annuum (CA) is a commonly consumed plant with potential neuroprotective properties. In this study, we aimed to identify potential lead compounds from CA that can target BACE-1 for AD therapy using molecular docking. Methods: A library of 15 compounds from CA was obtained from PubChem, …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 40–49 Read article
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Floating Cities from Concept to Creation :Neighbourhood Guide to the Future Development
Abstract: Today cities are overpopulated and only 40% of space is left to house the world's population by 2050. Due to ever rising sea level 90% of coastal cities will be affected by flooding by the end of the century. This research aims to study about the floating city as a substitute. Floating cities shape to construct all of the infrastructure required for a water-based metropolis while also providing contextual space …
Published in International Journal of Urban Design and Development Read article
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Qualitative and Quantitative Effects of Non-Thermal Atmospheric Pressure Plasma and ErCr: YSGG Laser Activation on Surface Remineralization and Fluoride Release of Three Different Fluoride Varnishes
Abstract: Dental caries remains a prevalent oral health concern worldwide, prompting ongoing research into innovative approaches for caries prevention and management. This experimental investigation endeavors to conduct a comparative assessment of the bioactivity, fluoride release kinetics, shear bond strength, and compressive strength of glass ionomer cement (GIC) augmented with three distinct types of inorganic bioactive nanoparticles. Bioactive nanoparticles have garnered interest in dental materials for their potential to enhance material properties …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 292–303 Read article
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Time and Frequency Response of Non-uniform Overhead Lines Under Corona
Abstract: This study presents an efficient and direct technique for determining both the time and frequency responses of non-uniform overhead power transmission lines operating under corona conditions. The assumed-line's non-uniformity is due to the conductors’ sag. Expressions will be presented for the location-dependent line surge impedance and the unevenly distributed lines’ electrical parameters. The analysis starts with solving the relevant system of differential and algebraic equations, subject to the boundary conditions. …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 2, Issue 2, 2024 · pp. 25–33 Read article
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Evaluating the Role of Platelet Indices, with a Focus on Immature Platelet Fraction (IPF), in Differentiating Hyper-Destructive and Hypo-Productive Thrombocytopenia: A Study from Ludhiana, Punjab, India
Abstract: Background: Thrombocytopenia, characterized by a reduction in platelet count, is commonly observed in clinical settings. Its etiology can be broadly classified into hyper-destructive thrombocytopenia, where platelets are destroyed at an accelerated rate, and hypo-productive thrombocytopenia, where platelet production is impaired. Differentiating between these two causes is essential for effective management. The Immature Platelet Fraction (IPF) has emerged as a promising non-invasive diagnostic tool to distinguish these causes. Objectives: The primary …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
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Comparative Study of Bioactive Phytochemicals from Hexane Extract of Two Amaranthaceae Leafy Vegetables by GC-MS Method
Abstract: Amaranthus tricolor Linn and Amaranthus viridis Linn, belonging to the Amaranthaceae family, are popularly consumed leafy vegetables in India and many other countries globally. The bioactive components of Hexane extract from these two plants have been analysed using gas chromatography-mass spectrometry (GC–MS) technique. According to analysis, both species contain a total of nineteen important chemicals. Of these, ten were found in A. tricolour L. and nine in A. viridis L. …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 7–17 Read article
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A Clinical Insight Into Management of Left Sided Hydrocele through Homoeopathy: A Case Report
Abstract: Hydrocele is a common condition in pediatric age groups, characterized by the accumulation of serous fluid within the tunica vaginalis surrounding the testis. While many cases resolve spontaneously within the first one to two years of life, persistent hydrocele beyond this period is generally managed surgically. The present case highlights the role of individualized homoeopathic treatment as a conservative approach in such conditions. A 2-year-old male child presented with left-sided …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 · pp. 1–11 Read article
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Generative AI-Based Inverse Design of Sustainable Biodegradable Polymers with Target Mechanical and Thermal Properties
Abstract: The escalating global plastic pollution crisis has intensified the urgent need for sustainable biodegradable polymer alternatives that can match or exceed the performance of conventional petroleum-based plastics while minimizing environmental impact. However, traditional polymer discovery approaches are severely constrained by high experimental costs, protracted development cycles spanning years, and fundamental inability to simultaneously optimize multiple conflicting material properties such as mechanical strength, thermal stability, and degradation kinetics. This study presents …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 Read article
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An Observational Study on Prevalence and Risk Factors for OA Knee Joint Among Adult Population Attending the SCSP Camps in Chennai, Tamil Nadu, India
Abstract: Background: Osteoarthritis (OA) is a prevalent degenerative condition affecting older individuals, particularly in developing nations. It is commonly linked to aging and various intricate underlying causes. The complex causes of osteoarthritis include confounding factors that significantly increase the risk of its development, many of which can be managed or prevented. Among all joints, knee osteoarthritis is particularly prevalent, especially in women. In rural India, the SC/ST population faces significant health …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 1, 2025 · pp. 9–17 Read article
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Multiphysics Simulation and Thermal Characterization of VVER-1200 Steam Generator for Optimized Heat Transfer and Structural Integrity
Abstract: VVER-1200 is a Russian design reactor which consist of Two circuits comprising reactor core, piping, vertical steam generator, pressurizer, active and passive safety systems, turbine and generator. This reactor involves single phase flow from reactor core to steam generator (SG) where high pressurized water exchanges heat with normal water resulting in steam production. The flow is turbulent, which enables maximum efficiency to heat transfer. Using ANSYS Workbench's multi-physics simulation capabilities, …
Published in Journal of Thermal Engineering and Applications · Vol. 13, Issue 1, 2026 · pp. 7–15 Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Exploring the Therapeutic Potential of Grapeseed Phytoconstituent Through Molecular Docking Analysis for Multiple System Atrophy Treatment
Abstract: Objective: Alpha-synuclein (α-Syn) aggregates are a common neurodegenerative disorder associated with Parkinson’s disease and multiple system atrophy (MSA). As a fruit that is extensively grown, grapes have several pharmacological advantages when it comes to reducing oxidative stress. Research has indicated that grape seed phytoconstituents have a major effect on α-Syn. The objective of this study is to inquire into the pharmacological characteristics and potential therapeutic applications of grape seed derivatives …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 14–26 Read article
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A Factorial Investigation of Hyperparameter Tuning Strategies for Lasso- Based Genomic Prediction
Abstract: In an earlier comparative study of machine-learning methods for genomic prediction of wheat grain yield, we reported a counter-intuitive result: automated nested-cross-validation tuning of the Lasso regularization penalty reduced mean predictive ability relative to a fixed, arbitrarily chosen penalty (mean Pearson r falling from 0.408 to 0.349 across four environments), the opposite of the expected effect of hyperparameter tuning. We hypothesized two possible explanations at the time — high-variance penalty …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 Read article
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Iota carrageenan, a Sustainable polymer transformed into a nanogel formulation, by using environment friendly method for antitumor action
Abstract: In the pharmaceutical field, the utilization of polymers, both in their natural form and through chemical modifications, holds immense importance. In this context, a novel and eco-friendly method for the synthesis of nano carrageenan-based polymers has been developed. The efficacy of carrageenan in this domain is attributed to its crosslinking and biological properties, which are largely influenced by its sulfate ion content. This study aims to formulate nanogels via a …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 881–889 Read article
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Analytical Method Development and Validation of Simultaneous Estimation of Natural Active Constituents Andrographolide and Piperine by UV Method.
Abstract: A simple, accurate, precise, and robust UV-Visible spectrophotometric method was developed and validated for the simultaneous estimation of Andrographolide and Piperine in bulk and combined pharmaceutical dosage forms. Preformulation studies confirmed favorable physicochemical properties for both drugs, including acceptable solubility profiles, melting points, pH values, and partition coefficients. The method development involved determination of λmax values at 224 nm for Andrographolide and 288 nm for Piperine using ethanol as solvent. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 3, 2025 · pp. 33–41 Read article
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Molecular Docking Analysis of Berberis aristata Phytocompounds as Potential Growth Factor Receptor Blockers in Cancer Therapy
Abstract: Middle-aged and older women are susceptible to breast cancer (BC), a potentially fatal condition. When breast cancer is diagnosed, the median age is 62. Breast cancer diagnoses in women under 45 are comparatively uncommon, whereas the bulk of breast cancer diagnoses occur in women 62 and older. Growth factor receptors are interesting therapeutic targets because of their critical role in the pathophysiology of cancer. Vascular endothelial growth factor receptors (VEGFR-2) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 1–10 Read article