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46 articles for “RNA”
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Next Generation Sequencing (NGS) in Personalized Medicine: Emphasizing Public Health Beyond Reality
Abstract: NGS is a modern technology that allows researchers to quickly sequence large amounts of DNA or RNA, it is also known as massively parallel sequencing or deep sequencing. NGS has revolutionized genomic research and biological sciences by its speed, scale, accuracy, ultra-high throughput, and cost. NGS replaced the conventional sequencing method. A novel idea in healthcare is precision medicine, which involves adjusting medical care to each patient’s unique traits and …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 · pp. 1–17 Read article
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Targeting Papain-Like Protease of Re-Emerging Coronaviruses
Abstract: Re-emerging Corona viruses (CoVs), including SARS-CoV (S-CoVs), and SARS-CoV-2 (S-CoV-2), continue to pose a global health threat due to their high mutation rates, zoonotic spillover potential, and capacity for immune evasion. The global pandemic of year 2019, caused by S-CoV-2, has highlighted the importance for robust antiviral strategies beyond vaccines and RNA polymerase or main protease inhibitors, which are susceptible to resistance. One promising therapeutic target is the S-CoV-2 papain-like …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 3, 2025 · pp. 46–62 Read article
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Investigation of Bio-Physical Interaction and Electrophoretic Properties of Fe3O4/DNA Nanocomposite and Colloids for Biomedical Application
Abstract: In recent years, research on magnetic nanoparticles has gained significant attention. The core concept behind their physics lies in their interaction with biomolecules such as hemoglobin, DNA, and RNA. This study examines the fundamental forces involved in these interactions, including van der Waals attractions, electrostatic repulsion, thermal effects, and magnetic coupling between nanoparticles and biological molecules. To describe these interactions quantitatively, parameters such as zeta potential, magnetic moment density, and …
Published in Research & Reviews : Journal of Physics · Vol. 14, Issue 3, 2025 · pp. 20–32 Read article
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Next-Generation mRNA Therapeutics: Self-Amplifying, Thermostable and Personalized mRNA Vaccines in the Era of Precision Medicine
Abstract: Messenger RNA (mRNA) technology has brought a major change in modern medicine, especially after its successful use in COVID-19 vaccines. However, early mRNA vaccines faced several problems such as low stability, strict cold storage requirements, and lack of personalized treatment. To overcome these challenges, next-generation mRNA technologies have been developed, including self-amplifying mRNA (saRNA), thermostable mRNA vaccines, and personalized mRNA vaccines. This article discusses the development of mRNA therapeutics, the …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 38–54 Read article
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Vaccines Through Time: Conventional Foundations and Next-Gen Innovations–Part 1
Abstract: Vaccination serves as a critical pillar of global public health, markedly decreasing infection rates and associated mortality. Traditional vaccine platforms such as live attenuated, inactivated, toxoid, and subunit vaccines have demonstrated effectiveness against pathogens like Mycobacterium tuberculosis and Plasmodium spp., yet they are constrained by antigenic variability, limited immune persistence, and complex production processes. Breakthroughs in synthetic biology, structural antigen design, and computational vaccinology have driven the development of advanced …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 1, 2026 · pp. 53–70 Read article
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Extracellular Vesicle-Based Liquid Biopsies: Decoding the Tumor Microenvironment for Precision Oncology
Abstract: The tumor microenvironment (TME) plays a pivotal role in cancer initiation, progression, and therapeutic response. Decoding the TME is, therefore, essential for advancing precision oncology. Extracellular vesicles (EVs), including exosomes and microvesicles, are nanoscale lipid bilayer particles secreted by tumor and stromal cells. They transport a wide range of bioactive molecules, such as DNA, RNA, proteins, lipids, and metabolites, which reflect the dynamic state of the TME. Recent advances in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 43–62 Read article