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1775 articles for “conditions”
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Autonomous Calibration of Medical Devices Using Synthetic Biosignals and Adaptive Learning
Abstract: The accuracy and reliability of modern biomedical diagnostic devices are critically dependent on effective calibration mechanisms capable of handling dynamic physiological and environmental variations. Conventional calibration approaches, which rely on static reference signals and manual adjustments, are inadequate in addressing challenges such as sensor drift, noise interference, motion artifacts, and long-term performance degradation. To overcome these limitations, this research proposes an innovative AI-driven adaptive biosignal simulation and calibration architecture for …
Published in Journal of Instrumentation Technology & Innovations · Vol. 16, Issue 2, 2026 Read article
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High-Performance Polymer Composite Membranes for Selective Ion Transport in Advanced Energy Conversion Systems
Abstract: The development of high-performance Polymer Composite Membranes (PCM) with enhanced ion transport is essential for Polymer Electrolyte Membrane Fuel Cells (PEMFC). However, low-humidity conditions and filter agglomeration still limit long-term membrane stability. This research designs a functionalized PCM integrating cross-linked Poly (Vinyl Alcohol)/Poly (Ethylene Glycol) (PVA/PEG) matrix with sulfonic acid functional groups and Titanium Dioxide (TiO₂) nanofillers to improve selective ion transport under low-humidity conditions. Two types of PCM were …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 724–736 Read article
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Seismic Response Characterization of Vertically Irregular Multi-Storey Buildings Incorporating Mass and Stiffness Variations Using E-TABS Software
Abstract: The increasing demand for innovative architectural designs has led to the widespread use of vertically irregular configurations in high-rise reinforced concrete (RC) buildings. However, such irregularities significantly influence structural performance under seismic loading conditions, leading to complex structural behaviour and stress concentration at specific levels This study focuses on evaluating the seismic behaviour of vertically irregular multi-storey buildings using nonlinear time history analysis, which provides a realistic representation of structural …
Published in Recent Trends in Civil Engineering & Technology · Vol. 16, Issue 3, 2026 Read article
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From Humours to Metabolism: An Integrative Review of Obesity Management in Unani Medicine
Abstract: Unani Medicine, a traditional complementary and alternative medicine (CAM) system, adopts a holistic, temperament-based approach to disease prevention and management. In classical Unani literature, obesity is described as Simān-e-Mufriṭ, a pathological condition arising from humoral imbalance, particularly the predominance of phlegm (Balgham) and derangement of temperament (Su’-e-Mizāj), most commonly of a cold and moist nature. This condition is attributed to a sedentary lifestyle, weakened digestive and metabolic faculties, and excessive …
Published in International Journal of Nutritions · Vol. 3, Issue 2, 2026 Read article
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Review on Comparative Analysis of Lateral Load Response of UG+G+7 Building Using Shear Wall, Bracing and Moment Resisting Frame Systems
Abstract: This review paper provides a relative analysis of lateral load-resisting systems in multi-storey buildings, specifically focusing on high-rise structural configuration. The study synthesizes findings from research Papers to evaluate the performance of shear wall systems, bracing systems, and moment-resisting frame systems under seismic and wind loading conditions. With the rising requirement for safe and efficient urban structures, understanding the behavior of different structural systems under lateral loads has become essential.The …
Published in Journal of Structural Engineering and Management · Vol. 13, Issue 2, 2026 Read article
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Design and Implementation of an Automatic Rain Sensing Wiper System Using SEN0545 Sensor and Raspberry Pi Pico W
Abstract: This study presents the design and development of an intelligent, automatic rain-sensing wiper system designed to enhance vehicle safety. The system utilizes a SEN0545 capacitive rain sensor, integrated with internal signal processing, and a Raspberry Pi Pico W microcontroller as its central control unit. The proposed approach enables non-contact and corrosion-free rain detection, ensuring reliable performance under varying environmental conditions. Based on the detected rainfall intensity, the controller dynamically adjusts …
Published in Trends in Electrical Engineering · Vol. 16, Issue 2, 2025 Read article
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Border Security Alert for Soldiers
Abstract: Secure a nation by protecting its people and the country’s borders. Soldiers guarding remote and hostile areas of the border experience very difficult situations when confronted with the possibility of arms and/or people crossing the border without permission and environmental conditions or obstacles that can impede communication. The proposed project titled, “Border Security Alert for Soldiers”, is an attempt to assist soldiers in their border surveillance efforts by using an …
Published in Journal of Microcontroller Engineering and Applications · Vol. 13, Issue 2, 2026 Read article
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MATLAB Simulation of Partial Power Converter with Dual- Mode Inverter for Solar Conversion
Abstract: The growing insertion of solar photovoltaic (PV) systems in the modern power systems requires high-efficiency, compact and reliable power conversion solutions. The traditional PV conversion system generally uses full-power processed DC-DC converters followed by inverters, which increases conduction and switching power losses, especially at higher power ratings. To overcome these challenges, this paper proposes a partial power processed resonant converter with a dual-mode transformer-less inverter for efficient solar PV power …
Published in Trends in Electrical Engineering · Vol. 16, Issue 2, 2025 Read article
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Intelligent Automated Guided Vehicle (AGV) System for Optimized Material Handling
Abstract: This project is the development of an Automated Guided Vehicle (AGV) system that has been developed to handle materials in the high-accuracy, reliability, and efficiency in industrial settings. The AGV is a combination of a blend of advanced technologies including sensor fusion, real-time path planning, and AI-based navigation to allow smooth and intelligent operation with minimal human intervention. The vehicle is able to efficiently identify, and evade obstacles by using …
Published in Trends in Mechanical Engineering & Technology · Vol. 16, Issue 2, 2026 Read article
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Unani Concepts of Brain Pathology: Humoral Mechanisms in Māddī Neurological Disorders
Abstract: Background The Unani System of Medicine (USM) considers the brain (Dimāgh) as the principal organ of Quwā Nafsāniyya (psychic faculties), responsible for sensation, cognition, memory, movement, and emotional regulation. According to Unani principles, health is maintained through equilibrium of Mizāj (temperament) and Akhlāṭ (humours), whereas disease develops when this balance is disturbed. Among neurological disorders, Sū’-i-Mizāj Māddī Dimāgh refers to pathological conditions of the brain associated with the accumulation of …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 2, 2026 Read article
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Review on Automatic Irrigation System
Abstract: The Automatic Irrigation System is a contemporary technological innovation aimed at improving water efficiency in farming and landscaping uses. This system guarantees that water reaches plants according to real-time data including soil moisture, weather conditions, and set irrigation schedules by combining sensors, microcontrollers, and automated valves or pumps. The main objective of an automated irrigation system is to increase water efficiency, decrease waste, and boost crop production while limiting human …
Published in Journal of Control & Instrumentation · Vol. 17, Issue 2, 2026 Read article
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Designing and Analysis of Different Types of Fins in Air Cooled Engine
Abstract: This paper is dedicated to the study of various shapes of extended surfaces, commonly known as fins, which are used on cylinder heads of internal combustion engines. Extended surfaces are used to improve heat dissipation from the object by increasing its effective surface area. Efficient heat dissipation is very important since proper cooling of an engine cylinder head helps to maintain optimal working temperatures, improves engine performance, increases service life, …
Published in Journal of Thermal Engineering and Applications · Vol. 13, Issue 1, 2026 · pp. 33–79 Read article
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Enhancing Smart Grid Resilience Through AI-Based Fault Classification
Abstract: Traditional power grids can be developed into smart grids, and they are comprised of the latest information and communication technologies (ICTs), which are based on establishing the relationship between the conventional electricity systems along with the usage of smart meters and distributed generation. This dynamic improves energy efficiency and the integration of renewables. Well, the dynamic and reversible power injection from Distributed Energy Resources (DERs) creates substantial operational problems. These …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 4, Issue 1, 2026 · pp. 10–15 Read article
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Medicinal Pteridophytes of Himachal Pradesh: Exploring Their Role in Alleviating Respiratory and Gastrointestinal Disorders
Abstract: Pteridophytes, comprising a diverse group of vascular cryptogams, have been widely used in traditional medicine for their medicinal properties. The therapeutic potential of different medicinal pteridophytes in treating gastrointestinal and respiratory conditions is investigated in this study. Their bioactive substances, including flavonoids, alkaloids, tannins, and saponins, which have anti-inflammatory, antibacterial, and antispasmodic properties, are highlighted by both traditional knowledge and recent research. Specific species, such as Adiantum capillus-veneris (maidenhair fern), …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
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Systematic Analysis of the Therapeutic Potential of Bacopa monnieri: A Wonder Therapeutic Plant
Abstract: Bacopa monnieri (L.) Wettst., a well-known perennial creeping herb, native to parts of America, the African subcontinent, and South Asia, had been a well-known nootropic plant, documented in ancient Indian systems of medicine, Ayurveda. The dynamic variations in the phytocompounds consortia, regulated by abiotic cultivation conditions and germplasm, provided a paradigm shift towards the exploring profound therapeutic effect of the plant along with advancements in scalable cultivation strategies. Tailoring the …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
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A Clinical Case Study of Kaphaja Visarpa W.S.R to Pemphigus Vulgaris
Abstract: Background: Visarpa is a classical Ayurvedic dermatological condition characterised by Swift spreading of lesions across the skin involving Twak, Lasika, Rakta, and Mamsa. Kaphaja Visarpa, a subtype dominated by Kapha dosha, presents with pallor-coloured oily lesions, itching, swelling, and mild pain. Case Summary: A 58-year-old female patient, a known case of Type 2 Diabetes Mellitus, presented with shiny, oedematous, pale skin lesions across the chest, abdomen, and back, accompanied by …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 2, 2026 Read article
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Analyzing Thermal Expansion in Polymer Composites Through Heat Transfer Simulations
Abstract: Although lightweight and strong, polymer composites require careful handling in environments where temperatures shift. Their usefulness in fields like aviation, vehicle manufacturing, and electronic devices comes from customizable heat behavior alongside favorable mechanical traits. Yet variation in size due to heating or cooling remains a concern hard to dismiss. As conditions change, expansion occurs - sometimes enough to disrupt fit, alignment, or function within complex systems. This response to warmth …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 Read article
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The Tapper Approach: An Integrated Framework for Land Degradation, Restoration, and Climate-Conflict Dynamics
Abstract: Land systems across the globe are increasingly exposed to multiple and interacting pressures, including land degradation, climate change, biodiversity loss, unsustainable land-use practices, rapid population growth, and socio-economic conflicts. These challenges not only reduce ecosystem productivity and resilience but also threaten food security, water availability, rural livelihoods, and long-term environmental sustainability. Despite the growing recognition of these interconnected issues, most existing conceptual and analytical frameworks continue to address them in …
Published in Research & Reviews : Journal of Ecology · Vol. 15, Issue 2, 2026 Read article
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Generative AI for Designing Sustainable Polymer Composites for Renewable Energy Applications
Abstract: Sustainable polymer composites are increasingly required for renewable energy devices, yet conventional trial-and-error formulation cannot efficiently balance performance, processability, recyclability, and environmental constraints. This study proposes a generative artificial intelligence framework for designing polymer composites for photovoltaic encapsulation, dielectric energy storage, polymer electrolytes, and thermal-management systems. Public polymer-property and composite datasets were curated from open databases and published supplementary records. Chemical descriptors, molecular fingerprints, polymer embeddings, processing variables, and sustainability …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 Read article