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445 articles for “expression”
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Hemophilia and Gene Therapy–Review
Abstract: The coagulation factor VIII or factor IX genes are affected by the monogenic mutational illness known as hemophilia. Recombinant clotting factors, which are secure and efficient, are the preferred palliative therapy. In order to ensure steady and long-lasting concentrations of the damaged circulating factor, advanced therapies will be curative. Adeno-associated vectors have primarily been used, and the results have been positive in terms of amounts and timings of expression. These …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 12, Issue 3, 2024 · pp. 1–5 Read article
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Exploring the Potentials of Quercetin and Kaempferol combinations along with Regular Antibiotics for the Effective Management of Methicillin-resistant Staphylococcus aureus (MRSA)
Abstract: The methicillin-resistant S. aureus (MRSA) is a bacterium that offers the challenge to numerous antibiotics which leads to a variety of problems, ranging from skin infections and sepsis to pneumonia. The natural products based management somewhat opened hope towards the betterment of the present era where the combination with currently available medicines has been studied clinically. Antibiotics (cefixime, ceftriaxone, erythromycin, ciprofloxacin, cephradine, methicillin, ampicillin, levofloxacin, and amoxicillin) and flavonoids (quercetin, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 3, 2018 · pp. 6–9 Read article
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Production, Optimization and Purification of Laccase Produced by Pleurotus ostreatus MH591763
Abstract: The optimization of production medium for laccase produced by Pleurotus ostreatus (Gene Bank Accession number MH591763) to reduce the cost of laccase production in large scale is the basic research in industrial field. In this study, the laccase culture medium was optimized for growth parameters such as incubation period, pH, temperature, carbon and nitrogen source on fungal growth and enzyme production. Purification and characterization of the enzyme was done by …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 9, Issue 1, 2019 · pp. 56–64 Read article
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Production and Characterization of Cardanol Based Schiff Complexes and their Biological Significance
Abstract: Synthesis and analysis of cardanol consisted Schiff base ligand along with its complexes such as Cu, Co and Ni are considered as a novel tetradentate cardanol contained Schiff base ligand molecules for various biological effects. It is prepared by the condensation reaction of 2-aminophenol and di-α formylmethoxybis (3-pentadecenyl phenyl) methane which is termed as DFMPM in the molar ratio of 2:1. The characterization of the experimental compounds is done with …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 9, Issue 2, 2019 · pp. 19–24 Read article
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Bacillus amyloliquefaciens: A Review
Abstract: Bacillus amyloliquefaciens is one of the many Bacillus species which is used as a probiotic, exerting health benefits to the host. B. amyloliquefaciens is a gram-positive, rod shaped bacteria with peritrichous flagella. The species also produces enzymes viz. cellulases, amylases, and proteases, which aid in digestion. The species is principally utilized as a feed additive substance for domestic animals and birds. It is gaining importance as plant growth promoter rhizobacteria …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 11, Issue 1, 2021 · pp. 9–17 Read article
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Effect of Chronic Inescapable Footshock and Antidepressant Treatment on BDNF/TrkB Levels in Rat Hippocampus
Abstract: Depression is a major health problem globally. Chronic stress arising out of life style or social factors may trigger depression, the molecular basis of which has been attributed to alterations of brain chemicals like neurotrophins. Among these neurotrophins, brain-derived neurotrophic factor regulates many physiological functions in the brain, alteration of which has been well associated with the pathogenesis of depression. Stress-induced helplessness in rodents constitutes a well-defined model to investigate …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 2, Issue 2, 2012 · pp. 12–21 Read article
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A Numerical Model to Study Effect of Potential-Dependent Influx on Calcium Diffusion in Neuron Cells
Abstract: Electrical activity within the brain rapidly encodes information about the world but for these fleeting perceptions to have a lasting impact, long-term changes in the structure and function of neurons must follow. At the synapse, neurotransmitter reception initiates a number of biochemical signaling cascades in the postsynaptic cells, one of the most important of which is the elevation of intracellular calcium. Early events induced by the rise of calcium in …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 4, Issue 1, 2014 · pp. 1–8 Read article
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Improvement of Motor and Sensory–Motor Behaviors after the Human Amniotic Epithelial Cells Transplantation in 6-OHDA Lesioned Corpus Striatum of Wistar Albino Rats
Abstract: Deficits in apomorphine-induced rotation and rotarod in rat have been proposed as a nondrug-induced model of the akinesia associated with the Parkinson’s disease. In the present study, we examined the disabilities in the rotarod and apomorphine-induced rotations have been observed after the 6-hydroxydopamine-induced denervation in the striatum. These impaired activities have reversed after the Human Amniotic Epithelial (HAE) cells transplantation during long-term observation. The neuronal densities and diameter were reduced …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 4, Issue 2, 2014 · pp. 34–45 Read article
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Caregivers’ Perception And Opinion About DMD Children With Neuro Rehab Services
Abstract: Duchenne muscular dystrophy (DMD) is the most common X-linked recessive disease. DMD is caused by the absence of dystrophin protein that helps to keep muscle cells intact. The onset symptoms occur during early wardhood, about 2–6 years of age. The clinical manifestations of DMD are generalized weakness followed by muscle wasting first affecting the muscles of the hips, pelvic region, thighs and shoulders girdle. The diagnosis of muscle biopsy shows …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 5, Issue 1, 2015 · pp. 5–14 Read article
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Pyogenic-Cerebral (Brain) Abscess
Abstract: Abscesses in the brain have been one of the most challenging wounds, both for surgeons and trainees. It is a packet full of pus of infected material in the part of the brain. It is an important neurological disease and can produce deadly diseases. Since the beginning of the era of computed tomography (CT), the diagnosis and treatment of these organizations has become simpler and less invasive. The results have …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 12, Issue 1, 2022 · pp. 33–46 Read article
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A Pre Experimental Study To Assess The Effectiveness Of STP Regarding Behavior Problem (Nail Biting, Pica, Conduct Disorder, Enuresis, Temper Tantrum) Among School Children Aged Between 10 – 15 Year In Selected School, Kashmir Province, Jammu & Kashmir.
Abstract: The primary aim of the study to assess the impact of structure teaching program on knowledge of school children regarding behavior problem with pica, enuresis, temper tantrum, nail biting, conduct disorder). Nursing is a profession that to be developed and emphasized with deep commitment to research. However it is only recently than nurses. In general has recognized the acute need for nursing research. In fact the future of nursing science …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 13, Issue 2, 2023 · pp. 1–7 Read article
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Application of Cholesteric Liquid Crystals in Oncology, Music Color Device and for Indication of Sorption Process
Abstract: The cholesteric liquid crystal films were used on the basis of the property of cholesteric liquid crystals under the change of the temperature to change their color, and the developed device for diagnostics of breast cancer that easy and productively permits to conduct the diagnostics with the high accuracy of colored image of benign or malignant tumor; the developed music color device, which permits to “revive” by the different colors …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 7, Issue 3, 2018 · pp. 1–11 Read article
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Induction of Apoptosis using Gene Therapy in the Treatment of Cancer
Abstract: Gene therapy is the treatment of a genetic disease through the insertion of normal or genetically altered genes into cells in order to replace or make up for the non-functional or missing genes. A major application of gene therapy is the induction of apoptosis to inhibit metastases or cure cancer. Besides the identification of the target site, the choice of a suitable vector system for gene delivery is also critical …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 2, Issue 3, 2013 · pp. 6–10 Read article
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Oral Manifestations of Haematological Disorders (RBC Disorders)
Abstract: Haematological abnormalities are diverse in nature, in its causation as well as in its clinical manifestations, most ofwhich are exhibitedin the oral cavity. In fact,the oral site in many instances could act as the forerunner of itsmanifestations before the expression of systemic signs and symptoms. The symptoms of haematological disorders are sovaried and nonspecific but often represent the initial sign of an underlying disease. Anaemic disorders are associated with orofacial …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 1, 2020 · pp. 18–22 Read article
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Relation of Thyroid Profile in Gall Stone Disease Patients
Abstract: Introduction: Gallstone disease is a very common gastro-intestinal disorder which is present worldwide. They may form because of many different disorders and the basis for it is impaired metabolism of cholesterol, bilirubin and bile acid and is characterized by formation of stones in hepatic or common bile duct or gall bladder. There has been a discussion, regard to the relation of thyroid disorders and gallstone disease, there are several explanations …
Published in Research and Reviews : Journal of Surgery · Vol. 6, Issue 2, 2017 · pp. 8–12 Read article
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Gossypetin Inhibits ROS Generation in HeLa and HepG2 Cell Lines
Abstract: Antioxidants are known for their ability to neutralize the reactive oxygen species present within the living system. These antioxidants are mainly secondary metabolites present in plant products and are generally known as nutraceuticals or bioactive compounds. Antioxidant can be categorized into many categories based upon their structure and activities like flavonoids, anthrocyanins and carotenoids. Flavonoids are heterogeneous polyphenolic compounds having beneficiary effect on human body and are also known to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 25–31 Read article
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Carbon Nanoparticles: Occupational Exposure and Genotoxic Effects
Abstract: The field of nanotechnology is revolutionizing today’s era by being the fastest emerging field. Though nanotechnology is the boon to the society, the potential toxicity of these nanoparticles should not be ignored as they can affect anyone from microbes to humans. The main focus of this paper is the toxicity of nanoparticles because people working in these areas, prone to nanoparticles are at high risk due to its toxic property. …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 1, 2015 · pp. 9–26 Read article
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Cadmium and Apoptosis: A Molecular Approach
Abstract: Apoptosis, also known as programmed cell death is a highly regulated and fundamental process found in all multicellular organisms. It is not only implicated in regulatory mechanisms of cells, but has been attributed to a number of diseases, like inflammation, malignancy, autoimmunity and neuro-degeneration. A variability of pollutants can persuade apoptosis. Oncogenic transition metals like cadmium, promote apoptosis alongside DNA base modifications, strand breaks and rearrangements. Generation of reactive oxygen …
Published in Research and Reviews: A Journal of Toxicology · Vol. 6, Issue 1, 2016 · pp. 8–17 Read article
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Organogenesis: Philosophy of Traditional Unani and Arab Medicine versus Modern Medicine
Abstract: The body is made up of different organs, which enable it to support the various structures and functions. These organs are developed from denser part of Akhlat (Humours) and Akhlat are made from Arkan (Basic constituents); every organ has its own functions but depends on other organ to perform them. There are two types of organs in human body, simple and compound, simple organs are homogeneous as their parts are …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 5, Issue 1, 2018 · pp. 13–16 Read article
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Clinical Validation of Unani Pharmacopoeial Formulation Majoon Suparipak in Sayalān Al-Rahim (Leucorrhoea)
Abstract: Leucorrhoea is a broad term commonly used for a condition where woman suffer from uterine, cervical or vaginal discharge other than blood due to genital tract infection or alteration in genital physiology and is highly prevalent (31–70%). In Unani medical literature it is described as Sayalān al-Rahim. According to Avicenna, uterus contains excessive waste products and hence prone to infection which leads to weakening of digestive faculty of uterine vessels …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 8, Issue 2, 2021 · pp. 28–35 Read article