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586 articles for “result” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Prediction of Molecular Targets for Anthraquinone and Its Analogs for Treatment of Good Pasteur Syndrome
Abstract: Objective: In order to find prospective molecular targets for the treatment of Good Pasteur Syndrome (GPS), a rare autoimmune disease that affects the kidneys and other organs, computational methods and network pharmacology were applied in this work. The goal of the study is to identify particular human proteins that might interact with anthraquinone and its analogues as well as to uncover potential mechanisms of action by which these drugs might …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Integrating Network Pharmacology and Molecular Docking to Assess Rutin’s Pharmacological Properties
Abstract: Objectives: In the present research, the network pharmacology process was applied to determine the underlying mechanism of the pharmacological properties of Rutin. Network pharmacology was utilized to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The identification of diverse drug-target interactions using network pharmacology may be utilized to discover novel medications for difficult conditions like …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 20–33 Read article
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Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article
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An Integrated Study to Extrapolate the Interaction of NMDAR with Potential Ligands for the Treatment of Alzheimer’s Disease Symptoms
Abstract: Objective: Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting the health status of older adults especially those above the age of 60 years. As an outcome, two types of medications have been developed for the treatment of its symptoms which are acetylcholinesterase (AChE) and N-methyl-D-aspartate receptor (NMDAR) antagonist. This paper uses the computational approach to understand the interaction of NMDAR with four major phytocompounds (curcumin, L-epicatechin, ginsenosides, and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 15–27 Read article
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Pharmacological Management of Parkinson’s Disease: Current Therapies and Emerging Treatments
Abstract: Objective: Parkinson's disease, behind Alzheimer's, is the second most common neurodegenerative ailment and a major cause of neurological morbidity worldwide. Clinical diagnosis is made, and current management is limited to symptomatic treatments, with levodopa remaining the cornerstone of pharmaceutical therapy. In certain patient groups, deep brain stimulation of specific basal ganglia targets can provide significant clinical relief. There are currently no proven disease-modifying medicines in clinical use that can halt …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 27–39 Read article
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Baggage Detection and Recognition Using Local Tri-Directional Pattern
Abstract: Nowadays, pattern-based image retrieval algorithms are gaining popularity just because of their uniqueness. There are several issues in the previously proposed systems. The proposed system resolves issues highlighted in the literature. Our proposed system is tested on two image datasets ILIDS and PETS 2006. LTDP provides good results as compared to LBP in baggage detection on two classes that either bag is present or not in an image because LTDP …
Published in International Journal of Mobile Computing Technology · Vol. 1, Issue 1, 2023 · pp. 8–17 Read article
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Assessing the Child–Parent Relationship Between Working and Non-working Mothers in a Selected Community of Bhubaneswar
Abstract: Introduction: Two categories of mothers exist: those who work outside the home, referred to as working mothers, and those who stay at home, often described as housewives. Working mothers may allocate quality time to their children, even if the amount of time is not necessarily large. On the other hand, non-working mothers not only manage household responsibilities but also provide care for their children and the entire family. Methods: A …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 1, Issue 2, 2023 · pp. 27–33 Read article
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A Rare Case of Serous Cystadenoma Ovary with Cholesterol Granuloma in an Adult Female
Abstract: In reaction to cholesterol crystals and foreign body giant cells, cholesterol granulomas are formed. These are the results of long-term inflammation brought on by the buildup of cholesterol crystals in tissues. The middle ear and paranasal sinuses are the most often reported locales; however, the mediastinum, breast, and ovary have all been implicated in a small number of cases. Here, we report a rare instance of an accidental ovarian cholesterol …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 13–17 Read article
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Importance of inflammatory marker ratio and lipid profile ratio in Acute Ischemic Stroke
Abstract: Background: Acute Ischemic Stroke is a chronic inflammatory disease that is projected to be one of the leading causes of mortality affecting millions of people globally. It is essential to study the Platelet lymphocyte ratio (PLR), Neutrophil lymphocyte ratio (NLR) ratios and C reactive protein (CRP) in impacting the inflammatory status during stroke. It is also important that altered lipid metabolism could influence the inflammatory conditions associated with AIS. Hence …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 19–31 Read article
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Examining the Impact of a Nurse Navigator Program on Anxiety, Psychological Well-being, and Quality of Life in Breast Cancer Patients at a Tertiary Care Hospital in Haryana: A Randomized Controlled Trial
Abstract: Background of study: Breast cancer stands as the leading cancer type affecting women and remains a significant contributor to female mortality. It is a complex ailment influenced by multiple factors. Globally, in 2020, approximately 2.3 million women received diagnoses of breast cancer, resulting in 685,000 fatalities. This condition can profoundly impact various aspects of a person's existence, encompassing physical, psychological, emotional, social, and familial spheres. A notable observation is the …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 1, 2024 · pp. 31–39 Read article
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Experiences of Women with the Labour and Delivery Care Received at Mzimba District Hospital, Malawi
Abstract: Aim: The aim of the study was to explore the perceptions of women on the care that they received during normal labour and delivery at Mzimba District Hospital, Malawi. Specific Objectives: To evaluate the aspects of physical care that was rendered to women during labour and delivery, evaluate the psychological care that was rendered to women throughout labour and delivery, assess the perception of women on the attitudes of midwives …
Published in International Journal of Women's Health Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 37–46 Read article
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Using Multitarget Molecular Docking to Examine the Antiviral Potential of Clerodendrum Phlomidis against Measles
Abstract: Objective: Measles, a viral disease caused by a member of the Paramyxoviridae virus family, is highly contagious and characterized by a respiratory illness and a maculopapular rash on the skin. Children are the main victims of the illness. In the context of drug development, this study investigates the efficacy of phytocompounds derived from Clerodendrum phlomidis against the target protein of the measles virus. Methods: The 7SKS protein was retrieved from …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 32–42 Read article
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Design and Implementation of High-Speed Low Power Low Area Hybrid One Bit Full Adder Using CMOS Technology
Abstract: In this article, we'll take a look at a new kind of Full Adder (FA) design that mixes traditional Complementary Metal Oxide Semiconductors (CCMOS) with Pass Transistors (PTs) and Transmission Gates (TGs). To analyze the circuit's performance, we used the Mentor Graphics software package. Since all twenty (20) varieties of Full Adder circuits were able to be measured and compared, this research was conducted. When the clock rate of the …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 1, Issue 2, 2023 · pp. 29–39 Read article
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Epidemiology and Mycological Analysis of Superficial Mycosis in a Northern Indian Tertiary Care Hospital
Abstract: Background: A fungal infection that affects the outer layer of the skin and its connective tissue, including hair and nails, is called superficial mycosis. These infections are typically caused by fungi, which thrive on keratin, the proteinthat makes up the nails, hair, and skin. A common disease that can affect people of any age, gender, or race is superficial mycosis. Usually, it appears as a streaky red rash that can …
Published in International Journal of Fungi · Vol. 1, Issue 1, 2024 · pp. 1–12 Read article
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Differentiating Real Versus Unreal in Children: An Investigation Using GIF Stimuli
Abstract: Virtual Reality Judgment is a part of cognitive development. With advancing cognitive development children will develop judgmental abilities enabling them to differentiate realty vs myth. This study explores the development of reality judgment abilities in typically developing children aged 3-6 years. Reality judgment, encompassing both character and action ability perception, is crucial for a child's accurate perception of the world. Existing research on reality judgment often stems from Western contexts, …
Published in International Journal of Children · Vol. 1, Issue 1, 2024 · pp. 01–04 Read article
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Electromagnetic Transients in Compensated Power Lines- Revisited: New Approach and Case Studies
Abstract: This paper addresses the simulation of the electromagnetic transients developed in high voltage power lines, which are initiated by lightning discharges. The analysis can handle both individual and simultaneous series inductive and shunt capacitive compensation types. The sizes and locations of the compensating elements are included in the analysis. The derived Laplace s-domain mathematical model applies the concept of the ABCD transmission constants representing equivalent two-port networks. The resulting currents …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 2, Issue 1, 2024 · pp. 19–26 Read article
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Effectiveness of Structured Teaching on Immunization Knowledge and Attitude Among Mothers of Children Under-5 years of Age at Bal Mahila Chikitsalaya, Lucknow
Abstract: This section offers a thorough overview of the study's background, explaining the significance of vaccination, the variables affecting vaccination coverage, the role mothers play in the decision-making process regarding vaccinations, and the necessity of focused interventions to improve immunization uptake among children under five. As a fundamental component of preventive healthcare, immunization shields both individuals and communities from a variety of infectious diseases. In order to comprehensively assess changes in …
Published in International Journal of Children · Vol. 1, Issue 1, 2024 · pp. 5–22 Read article
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Novel Laplace-domain Approach to the Electromagnetic Transients in Compensated High Voltage Power Lines
Abstract: This paper addresses the simulation of the electromagnetic transients developed in high voltage power lines, which are initiated by lightning discharges. The analysis can handle both individual and simultaneous series inductive and shunt capacitive compensation types. The sizes and locations of the compensating elements are included in the analysis. The derived Laplace s-domain mathematical model applies the concept of the ABCD transmission constants representing equivalent two-port networks. Applying the relations …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 2, Issue 1, 2024 · pp. 15–21 Read article
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Assessment of exacerbation of Depression in pulmonary tuberculosis patients by using PHQ-9 scale at Tertiary Care Hospital
Abstract: Context: Depression leads to more dysfunction and stress, which could affect the patient's life condition. Tuberculosis is a leading cause of comorbidity with depression. Those suffering from tuberculosis and depression are at higher risk of bad health-seeking nature, resulting in higher morbidities, drug resistance, and mortality. The relationship is not well established. Aims: To identify multiple variables/ dependent factors affecting depression respectively in tuberculosis patients and check the medication adherence …
Published in International Journal of Pathogens · Vol. 1, Issue 2, 2024 · pp. 24–31 Read article
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“Evaluation of superoxide Dismutase (SOD) enzyme level and some indicators in people exposed to smoke”
Abstract: The aim of this study is to assess the level of SOD enzyme and its impact in people who are exposed to smoking, in addition to measuring C-interactive protein, and finally measure a complete picture of blood samples taken from patients. The results of the current study showed there is a significant differences (p<0.05) in the activity of the SOD. The mean of SOD activity in patient was 127.9 U/ml …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 52–55 Read article