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23 articles for “metabolic disruptions”
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Exploring Potential Phytochemicals for Myasthenia Gravis Treatment: A Molecular Docking and ADME Analysis Approach
Abstract: Objective: Muscle feebleness and exhaustion derived from a disruption in neuromuscular transference are hallmarks of the crippling autoimmune disease myasthenia gravis (MG). The drawbacks of the current MG therapy options are frequently partial efficacy and adverse effects. To investigate the potential of phytochemicals in MG control, in this work we integrated molecular docking with ADME (absorption, distribution, metabolism, and excretion) analysis using a computer method. We identified molecules exhibiting favorable …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article
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Understanding the Impact of GMO on Hormones and Their Effect on Mood: A Review Paper
Abstract: The research evaluates how consuming genetically modified organisms affects endocrine functioning that can potentially lead to mood changes or disorders. This is a systematic review paper that analysed sixty publications before selecting thirty which were obtained from Sciencedirect, Frontiers, Springer, Oxfordacadamic, Cabidigitallibrary, Wileyonlinelibrary, Cambridgeuniversitypress, Scijournals, Mdpi, Metabolismjournal; while using Prisma Flow Diagram as the research tool; acknowledging that human hormonal health risks from GMO consumption remain largely unknown due to …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 14, Issue 3, 2025 Read article
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Stingless Honeybee’s Rare Sugar and PCSK 9 - LDLR Interaction, A New Hope for Hormone Dependent Breast Cancer Patients – An In-silico Study
Abstract: Hypercholesterolemia is a lipid disorder characterized by elevated levels of low-density lipoprotein (LDL), commonly known as "bad" cholesterol. This condition is a significant risk factor in the development and progression of hormone-dependent breast cancer, as well as in the emergence of resistance to hormonal therapy. One of the key regulators of cholesterol metabolism is the proprotein convertase subtilisin/kexin type-9 (PCSK9) protein, which facilitates the degradation of the LDL receptor (LDLR) …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article