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32 articles for “Cellular signaling”
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Phosphorescence of Carbon Nanodots – The Phenomena and the Applications
Abstract: Photoluminescence has emerged as a fundamental phenomenon in modern biomedical science, enabling advanced diagnostic, therapeutic, and theranostic applications through light–matter interactions at the nanoscale. The ability of photoluminescent materials to absorb electromagnetic radiation and emit light at distinct wavelengths has been widely exploited in bioimaging, biosensing, drug delivery tracking, and photodynamic therapy. Among various photoluminescent nanomaterials, carbon nanodots have attracted significant attention due to their strong emission intensity, tunable fluorescence, …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 01–05 Read article
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Non-Enzymatic Glycation in Alzheimer’s and Parkinson’s Disease: A Molecular Approach to Pathology and Recent Advances
Abstract: Non-enzymatic glycation, a biochemical process by which reducing sugars spontaneously bind to proteins, leads to the formation of advanced glycation end-products (AGEs), which have emerged as critical contributors to the pathogenesis of several neurodegenerative diseases, particularly Alzheimer’s disease (AD) and Parkinson’s disease (PD). The accumulation of AGEs can significantly alter protein structure, stability, and function, triggering a cascade of detrimental effects, including increased oxidative stress, heightened neuroinflammation, and the promotion …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 36–41 Read article
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ISGylation: A Key Host Cellular Defense Mechanism
Abstract: ISGylation, a crucial process of the innate immune response, has garnered increasing attention for its involvement in host's defense against pathogenic infections as well in cancer progression. The key player of ISGylation, ISG15, is stimulated by type I interferons (IFNs). ISG15 covalently binds with viral (influenza NS1A and nucleoproteins) and host (Nedd4, filamin B and CHMP5) target proteins and this interaction inhibits the viral replication process and release of viral …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 2, 2024 · pp. 68–80 Read article
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Microwave Signals: A New Frontier in Non-Invasive Medical Diagnostics: A Study
Abstract: Imagine a future where medical diagnoses are quicker, safer, and more accessible, and where therapies are more precise and less invasive. This future is rapidly approaching, driven in part by the quiet revolution of microwave signals in medicine. Far from their everyday use in ovens and communication, these non-ionizing electromagnetic waves are proving to be powerful tools, offering unprecedented insights into the human body and innovative ways to treat disease. …
Published in Journal of Microwave Engineering and Technologies · Vol. 12, Issue 3, 2025 · pp. 27–41 Read article
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Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies
Abstract: In the past few decades, comprehensive evidence has convincingly established the presence of cancer stem cells (CSCs) as a minor subset within tumors, contributing to an unusually elevated level of cellular diversity within the malignancy. CSCs are functionally identified by their capacity for self-renewal and differentiation, frequently influenced by signals from their surrounding microenvironment. The interconnected transcriptional, post-transcriptional, metabolic, and epigenetic regulatory networks govern the biological characteristics of CSCs. CSCs …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 14–18 Read article
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Current Drugs Target the EGFR
Abstract: Cancer is a devastating disease, but there have recently been significant advancements in therapy that have identified EGFR and its related proteins as valuable indicators and targets for treatment. The ERBB receptor tyrosine kinase superfamily includes EGFR, which is a transmembrane glycoprotein. When the EGFR receptor interacts to its particular ligand, EGF, it causes tyrosine residues to be phosphorylated and forms receptor dimers with other members of the receptor family. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 1–8 Read article
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A Comprehensive Review of Metabolite
Abstract: Metabolites, tiny chemicals, are essential to physiology, signalling, and biological function. This extensive review classifies metabolites into primary and secondary categories by biological relevance. Alkaloids, flavonoids, and terpenoids contribute to ecological interactions and defence systems, while amino acids, nucleotides, and carbohydrates directly affect development and cellular function. The article examines metabolic pathways, mass spectrometry, NMR, and metabolomics, a growing field. Metabolites play a crucial role in various scientific and practical …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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Metabolic Reprogramming in Carcinogenesis: An Overview
Abstract: Metabolic reprogramming is a crucial mechanism via which cells modify their metabolic pathways to adjust to changes in the environment and maintain growth, survival, and function. This phenomenon is of utmost importance in a wide range of physiological and pathological situations, specifically in cancer, immunological responses, and stem cell biology. In cancer, metabolic reprogramming facilitates fast cell growth and survival, as demonstrated by the Warburg effect, where cancer cells prioritize …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article
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Practical studies in Vero cell and Human amnion cells for viral and stem cell applications
Abstract: Vero cells are one of the most popular mammalian continuous cells in molecular, cellular, and microbiological research. African green monkey kidneys are used to make these.One continuous cell line is the Vero cell line. This cell line is dependent on anchorage. Vero cells can be cultured in suspension because they are anchorage independent. Thought to be non-tumorigenic cells that came from a female Chlorocebus sabaeus Numerous viruses can infect vero …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 1–8 Read article
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Unraveling the Nexus: Parkinson's Disease, Alpha-synuclein, Desulfovibrio, and the Gut Microbiome
Abstract: Parkinson's disease (PD) is now recognized as a chronic condition which is once considered a highly intricate disorder involving the central, autonomic, and enteric nervous systems. The prevailing perspective attributes the disease by the formation of Lewy bodies, primarily triggered by the misfolding of α-Synuclein, leading to the demise of dopaminergic neurons in the substantia nigra. Constipation, one of the most common non-motor symptoms in PD patients, is believed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 18–28 Read article
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DEVELOPMENT OF POLYMERSOMES AS MACROMOLECULAR PLATFORMS FOR NANOMEDICINE
Abstract: The conventional method of drug delivery is plagued with instability, low targeting and low bioavailability. A solution to these shortcomings is the use of polymer Somes, artificial vesicles that are produced through self-assembly of amphiphilic block copolymer, and they are suggested as universal nanoscale carriers. They have stiff, tunable membranes (thickness = 2-50 nm) due to accurate control of polymer chemistry, chain length, and hydrophilic mass fraction (f), which allows …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article