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64 articles for “ADME prediction”
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Kisan Mantra: Enhancing Farmer Productivity, A Web-Based Approach for Efficient Crop Harvesting and Problem Diagnosis
Abstract: India's agricultural sector faces persistent challenges, including limited access to expert guidance, difficulties in managing diverse datasets, unreliable weather forecasting, and a lack of real-time monitoring for farm activities and crop quality. Additionally, farm lenders struggle to obtain accurate insights into farm productivity and risks, hindering their ability to provide tailored financial solutions. The sector also grapples with underemployment among educated professionals, limiting their contributions to agricultural advancement. To tackle …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 14, Issue 3, 2025 · pp. 71–87 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Artificial Intelligence and the Future of Education
Abstract: Artificial Intelligence (AI) refers to the capability of a computer system to mimic human intelligence by performing tasks such as learning, reasoning, problem-solving, and decision-making. As a rapidly evolving and emerging technology, AI holds the potential to transform a wide range of sectors, including healthcare, transportation, business, and notably, education. Its application in the educational domain is gaining momentum, aiming to create more efficient, engaging, and personalized learning environments. Incorporating …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 3, 2025 · pp. 39–44 Read article
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Comparative Evaluation of GPBB and CK-MB in Early Diagnosis of Acute Myocardial Infarction in Diabetic and Non-Diabetic Patients
Abstract: Background: Acute myocardial infarction (AMI) continues to be a leading cause of morbidity and death among people worldwide. To lower the risk of problems, early and precise diagnosis is essential, particularly for diabetes patients. The study investigates the diagnostic value of Glycogen Phosphorylase BB (GPBB), a potential early biomarker of myocardial necrosis, and compares it with CK-MB, a widely used cardiac marker, in AMI diagnosis. Inflammatory markers (hs-CRP, IL-6, TNF-α) …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 33–37 Read article
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Experimental Study on Heart Disease Prediction Using Different Machine Learning Algorithms
Abstract: Heart disease which can also be referred to as the cardiovascular disease is one of the raising concerns in today’s world. It is one of the major health problems causing death among humans irrespective of the age group and therefore has made it necessary to look into different medical factors that are required to predict the same in advance using the collected historical datasets of various patients. Thus we have …
Published in Journal of Artificial Intelligence Research & Advances Read article
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Clinical Profile of Dengue Patients who had a Prior Infection with the Covid 19 Virus in a Tertiary Care Centre
Abstract: This cross-sectional analytical study conducted in a tertiary care center aims to investigate the clinical profile of Dengue virus-infected patients with a prior history of COVID-19 within the last three years. Dengue, a prevalent tropical disease, ranges from mild fever to severe conditions like hemorrhagic fever and shock syndrome. The study utilizes the World Health Organization's 2009 classification for Dengue and delineates the febrile, critical, and recovery phases of infection. …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 34–38 Read article
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Screening Phytocompounds of Tinospora cordifolia to Find Potential Drug Targets for Cystic Fibrosis
Abstract: This study aimed to evaluate the therapeutic potential of phytocompounds derived from Tinospora cordifolia in treating cystic fibrosis (CF), a genetic disorder caused by mutations in the CFTR gene that lead to severe respiratory and digestive complications. Phytocompounds were retrieved from the IMPPAT database and subjected to molecular docking simulations using PyRx to assess their binding affinity to the CFTR protein. The top-scoring compounds – sterol, magnoflorine, tembetarine, kaempferol, and …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 16–24 Read article
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Exploring Glucagon-like peptide-1 as a Target Protein for Diabetes Mellitus Treatment: Molecular Docking and Pharmacokinetic Analysis of Phytocompounds from Momordica charantia
Abstract: Objective: This study aimed to use molecular docking techniques to explore the potential of GLP-1 (glucagon-like peptide-1) as a target protein for the treatment of diabetes mellitus, a chronic metabolic disease marked by elevated blood glucose levels. Given its crucial role in maintaining insulin secretion and glucose homeostasis, GLP-1 may serve as a future target for diabetes therapy. Method: The study employed a multi-phase method. Initially, protein extraction was carried …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 8–20 Read article
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Comparison of Several Clinical Scoring Systems in Predicting the Outcome of Variceal Bleeding
Abstract: Background: Stratification of variceal bleeding patients into high-risk and low-risk group is very important to guide them through the suitable clinical pathway and to save the medical costs. We purposed to find out the best scoring system in the prediction of rebleeding and death after variceal bleeding by comparing four clinical scoring systems(clinical Rockall score, complete Rockall score, AIMS65 score, Child-Pugh score) which seemed to be applicable and simple. Method: …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 2, 2025 Read article
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Smart Framework for Personal Fuel Expense Tracking and Carbon Emission Assessment
Abstract: This study presents a smart system that is intended to assist individuals and administrators in tracking their fuel costs and keeping an eye on their daily carbon emissions. It makes it simpler to make decisions by examining fuel consumption and its effects on the environment. The technology gathers real-time emissions data from vehicles equipped with Internet of Things devices. It can predict future trends of emissions by utilizing AI-based predictive …
Published in Journal of Thermal Engineering and Applications · Vol. 11, Issue 3, 2024 · pp. 36–44 Read article
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Challenges And Constraints Affecting Female-Owned Rural Farm Businesses in Plateau State, Nigeria
Abstract: This study examined the challenges and constraints affecting female-owned rural farm businesses in Plateau State, Nigeria. No prior study had conducted a comprehensive, quantitative, state-wide investigation covering all 17 local government areas (LGAs) of the state, and this study addressed that gap. The objectives were to identify the challenges faced by female-owned rural farm businesses, assess their relationship with business performance, and determine how strongly these challenges predicted performance outcomes. …
Published in International Journal of Rural and Regional Development · Vol. 4, Issue 1, 2026 · pp. 1–13 Read article
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Integrated Surface Water–Groundwater Dynamics: Implications for Pollution Pathways, Prevention, and Environmental Control
Abstract: Water resources worldwide are increasingly threatened by pollution pressures amplified by climate change and intensified human activities. The vulnerability of surface water and groundwater systems to contamination is strongly governed by their dynamic hydrologic connectivity, which is often overlooked in pollution prevention and control frameworks. Rising global temperatures, altered precipitation regimes, land-use change, and intensified abstraction patterns modify recharge processes, flow paths, and contaminant transport mechanisms across environmental landscapes. This …
Published in International Journal of Pollution: Prevention & Control · Vol. 4, Issue 1, 2026 · pp. 34–40 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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Forecasting Climate-Driven Healthcare Demand in Agricultural Regions: A Multi-Modal AI Approach
Abstract: The rapidly increasing instability of world climatic regimes has made past meteorological thresholds irrelevant, especially in the agricultural areas where monetary stability and well-being of humans are closely intertwined with an environmental situation. The more the frequency of 1 in every 1000-year events, i.e., heatwaves and catastrophic flooding increase, the greater the rural healthcare systems are in crisis, i.e., unable to predict a surge in demand because of data scarcity, …
Published in International Journal of Climate Conditions · Vol. 2, Issue 2, 2025 · pp. 28–38 Read article
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Exploring the Potential of Allium sativum Phytocompounds as B-Cell Leukemia 2 Inhibitors in Acute Lymphoblastic Leukemia: Molecular Docking Study
Abstract: Objective: Acute lymphoblastic leukemia (ALL) is a lymphoid progenitor cell malignancy that could be treated with plant-based drugs, thus alleviating the off-target effects caused by conventional chemotherapy. Since ancient days, Allium sativum has been an integral part of traditional medicine and an excellent antimicrobial, antioxidant, and antiproliferative agent. Hence, this study aims to assess the anti-leukemic potential of A. sativum phytoconstituents as the B-cell leukemia 2 protein (Bcl-2) natural inhibitor …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 53–80 Read article
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AI: Revolutionizing Pharmacy Practice and Enhancing Patient Care and Safety
Abstract: The use of artificial intelligence (AI) in pharmacy is transforming medication management, improving patient care, and boosting safety. By leveraging cutting-edge technologies, such as machine learning, natural language processing, and predictive analytics, AI enables pharmacists to develop personalized treatment plans and anticipate possible adverse drug reactions. AI-driven systems enhance operational efficiency by streamlining inventory management, prescription processing, and administrative duties, allowing pharmacists to devote more time to patient care. Additionally, …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 1, 2025 · pp. 13–20 Read article
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Energy Management Using Hybrid Energy Storage System In DC Microgrid: A Review
Abstract: The purpose of this paper is to study the power management of a hybrid energy storage system in a DC microgrid. The energy storage system for microgrids is bound to face several challenges, such as a lack of conventional power sources and load imbalance. There are many losses in using HEMS that require a microgrid to optimize performance and extend hybrid energy storage systems. The HESS incorporates a battery energy …
Published in Trends in Electrical Engineering · Vol. 14, Issue 1, 2024 · pp. 37–43 Read article
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Computational Investigation of Phytochemicals Targeting AKT1 for Major Depressive Disorder: A Molecular Docking and ADMET Study
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric condition affecting approximately 280 million individuals worldwide, with women exhibiting a 50% higher likelihood of diagnosis than men. Despite significant advancements in treatment, MDD remains a chronic and relapsing disorder, necessitating the exploration of novel therapeutic interventions. This study focuses on the AKT1 gene, a key player in neuropsychiatric disorders, and investigates its interactions with natural phytochemicals as potential alternatives to conventional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Targeting Dystrophin Restoration and Neuroprotection in Duchenne Muscular Dystrophy: Insights from Withania somnifera
Abstract: Duchenne muscular dystrophy is a genetic disorder. This disease affects men more common than women. Main objective of the present study was to identify the naturally active phytocompounds from Withania somnifera (Ashwagandha). Ashwagandha has a great value in the field of Ayurveda and Indian medicine and is used for treating muscular and neurological disorders. Toxicity prediction, molecular docking, statistical information, drug illness prediction, and Absorption, distribution, metabolism, excretion, and toxicity …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 64–84 Read article
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Evaluating Delay Impacts: From Root Cause Analysis to Dispute Resolution
Abstract: Construction projects inherently involve complex coordination among multiple stakeholders, interdependent tasks, and unpredictable external challenges, which frequently cause schedule overruns and disputes. Traditional contractual mechanisms—such as extensions of time (EoT), liquidated damages, and force majeure clauses—serve to define responsibilities, allocate risk, and establish formal dispute pathways when delays arise. For example, EoT provisions protect contractors from penalties when delays are beyond their control, provided proper notice and evidence are submitted …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 3, 2025 · pp. 11–25 Read article