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245 articles for “sequencing”
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Unveiling Actionable Pathogenic Genes for Precision Oncology in Brain Cancers: Glioblastoma and Astrocytoma
Abstract: Glioblastoma (GBM) and astrocytoma are aggressive primary brain tumors characterized by significant molecular heterogeneity, complicating effective treatment. This study employed targeted next-generation sequencing of 529 cancer-associated genes on matched tumor-normal pairs from GBM and astrocytoma patients. Somatic variants were identified using a rigorous bioinformatic pipeline adhering to GATK Best Practices, with variant allele frequencies (VAF) calculated to assess clonal dominance. Functional annotation and driver mutation classification were performed using Ensemble …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 · pp. 43–59 Read article
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Proteins: Structure, Functions, Sources, Types, Advantages and Biological Importance
Abstract: Proteins are essential biological macromolecules composed of amino acids linked by peptide bonds and folded into specific three-dimensional structures. Their structural organization is closely associated with their biological functions, including structural support, catalysis, transport, regulation, defense, movement and storage. This review summarizes the basic features of proteins, including amino-acid composition, levels of structural organization, classification, major biological functions and important dietary sources. It also discusses the relationship between amino-acid sequence, …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 4, Issue 2, 2026 Read article
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Harnessing Artificial Intelligence for Precision Physics: A Machine Learning Framework for Data Reconstruction in Support of India's Deep-Tech Missions
Abstract: India's emergence as a global leader in deep-tech innovation is driven by ambitious scientific megaprojects, including the Laser Interferometer Gravitational-Wave Observatory (LIGO)-India, the X-ray Polarimeter Satellite (XPoSat), the Aditya-L1 solar observatory, and the National Quantum Mission (NQM). However, the unprecedented scale and complexity of the observational data generated by these missions present severe computational bottlenecks. Traditional analytical frameworks struggle with non-stationary noise transients, diffusion blurring, and the exponential scaling limits …
Published in Research & Reviews : Journal of Physics · Vol. 15, Issue 2, 2026 · pp. 48–55 Read article
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Numerical Investigation of Ply-by-Ply Failure and Strength Degradation in Composite Laminates Under Transverse Loading
Abstract: This paper represents the failure analysis of composite symmetric and antisymmetric laminate, when laminates were subjected to the transverse loading conditions. The load is uniformly distributed in a transverse direction. The analysis includes failure load and nature of failure by using theories of failure. The ply degradation material model is used to modify and update the properties of failed lamina and upgrades the properties of laminate. Laminate is modelled as …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
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Next-Generation Biorepositories: Accelerating Infectious Disease Research and Vaccine Innovation
Abstract: Next-generation biorepositories have emerged as critical infrastructure for advancing infectious disease research and accelerating vaccine development. By integrating cellular, genomic, and clinical data within harmonized frameworks, these repositories overcome traditional limitations of fragmented datasets and limited interoperability. The evolution from conventional biobanks to digitally enabled, multi-omics platforms has enabled comprehensive analysis of pathogen–host interactions, facilitating the identification of novel vaccine targets and correlates of protection. The COVID-19 pandemic underscored the …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 Read article