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1071 articles for “interaction”
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In Silico Screening and Evaluation of Some Metabolites from Momordica charantia in the Treatment of Peptic Ulcers
Abstract: Peptic ulcers are also called as or duodenal ulcers or gastric ulcers that are open sores generally develop in the lining of the stomach due to food and climatic factors. H. pylori infections are potentially the most dangerous and are linked to several diseases like diabetes, cancer, cardiovascular diseases, etc. In the present study, in silico screening and evaluation of some metabolites from Momordica charantia like Momorcharin, Momordicin, Metformin, Pioglitazone, …
Published in Research and Reviews : Journal of Computational Biology Read article
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Prediction of Molecular Targets for Anthraquinone and Its Analogs for Treatment of Good Pasteur Syndrome
Abstract: Objective: In order to find prospective molecular targets for the treatment of Good Pasteur Syndrome (GPS), a rare autoimmune disease that affects the kidneys and other organs, computational methods and network pharmacology were applied in this work. The goal of the study is to identify particular human proteins that might interact with anthraquinone and its analogues as well as to uncover potential mechanisms of action by which these drugs might …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Integrating Network Pharmacology and Molecular Docking to Assess Rutin’s Pharmacological Properties
Abstract: Objectives: In the present research, the network pharmacology process was applied to determine the underlying mechanism of the pharmacological properties of Rutin. Network pharmacology was utilized to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The identification of diverse drug-target interactions using network pharmacology may be utilized to discover novel medications for difficult conditions like …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 20–33 Read article
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A Virtual Reality—Metaverse and Its Trends
Abstract: In 1992, the concept of a metaverse was first introduced to the public. Metaverse, as its name implies, is a mashup of the terms "meta" and "universe," where "meta" is Greek for "beyond”. As a result, it means beyond our current understanding of the universe. It exists in the virtual world but feels just as real. In a metaverse, various virtual spaces are combined into a single, persistent, 3D environment. …
Published in International Journal of Information Security Engineering · Vol. 1, Issue 1, 2023 · pp. 44–49 Read article
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A Structure-based Design Approach to Catharanthus roseus Phytoconstituents as Potential Inhibitors of B-Cell Lymphoma 6 Protein
Abstract: Objectives: Lymphoma is a cancerous disease. It develops into millions of people worldwide. Identify the naturally active compounds from Catharanthus roseus, they have multiple values in the medicinal field of Siddha, and Indian Ayurveda are used as a disease-preventing agent. Drug illness prediction, toxicity prediction, statistical information, molecular docking, as well as absorption, distribution, metabolism, and excretion (ADME) analysis are used to predict the fit ligand as a drug. Methods: …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 14–34 Read article
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Isolation and Evaluation of Aspergillus Niger : A Fungi Implicated in Infectious Diseases and its application as potential Biofertilizer
Abstract: In the quest to improve the agronomic effectiveness of Rock Phosphate (RP), a widely available and cost-effective phosphate fertilizer, this study aimed to overcome its limited solubility by isolating fungal strains capable of solubilizing rock phosphate. Soil samples were collected from Garhmukteshwar, Hapur, for the isolation process. Among several isolates, three strains exhibited the highest rock phosphate solubilization within a seven-day timeframe, coinciding with a significant decrease in soil pH. …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 29–34 Read article
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The effect of cooling time and colorant pigment on the dimensional accuracy of plastic injection molded closure
Abstract: Dimensional accuracy is a critical aspect of precision injection molding, with the products generally required to conform to set tolerances. Major causes of these deviations are reported to be related to the polymer material, part geometry, injection mold design, and process parameters. This study investigated the effects of material color pigment and its interaction with process cooling time on product dimensional accuracy. This study was conducted experimentally, where three levels …
Published in Journal of Polymer & Composites · Vol. 11, Issue 12, 2023 · pp. 93–100 Read article
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Assessment of Finerenone Safety and Efficacy in Individuals with Type 2 Diabetes and Chronic Kidney Disease
Abstract: Background: In this work, we provide strong evidence for the safety and efficacy of finerenone in people with type 2 diabetes and chronic kidney disease. Our goal is to improve patients' quality of life and general well-being through our research. Aim: Finerenone exhibited a significant decrease in the likelihood of renal and cardiovascular (CV) events in individuals with both type 2 diabetes and chronic kidney disease. This exploratory subgroup analysis …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 06–09 Read article
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Grid based docking study of some 2-(4-methylsulfonyl phenyl) pyrimidine derivatives (designed after QSAR studies) with Cyclooxygenase
Abstract: Molecular docking helps in studying drug/ligand or receptor/ protein interactions by identifying the suitable active sites in protein, obtaining the best geometry of ligand-receptor complex and calculating the energy of interaction for different ligands to design more effective ligands. In Grid based docking, after unique conformers of the ligand are generated, the receptor cavity of interest is chosen and a grid is generated around the cavity. Cavity points are found …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 23–41 Read article
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Machine Learning Based House Price Forecasting
Abstract: This research endeavours to craft a predictive model leveraging machine learning to estimate the market value of houses in Delhi. By integrating Python and its powerful libraries, pandas for data processing, Plot for interactive visualizations, scikit-learn for implementing machine learning algorithms, XGBoost for boosting the model's prediction accuracy, and to evaluate the model's performance cross-validation techniques are used. An interactive user interface is created using a Flask web application to …
Published in Current Trends in Information Technology · Vol. 14, Issue 1, 2024 · pp. 5–11 Read article
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Artificial Intelligence Threat to Human Activities
Abstract: This study explores the multifaceted impacts of Artificial Intelligence (AI) across human activities which must be employment, privacy, social interactions, proper decision-making, and also the ethical considerations. It tries to get closer to the bottom of AI's complicated behavior by focusing on its changes, problems, and moral roots in human activities. A careful review of the research shows where there are holes and gives a full picture of the dangers …
Published in Journal Of Network security · Vol. 12, Issue 1, 2024 · pp. 8–12 Read article
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Using AIML to Enhance Demand Forecasting in Business
Abstract: Artificial intelligence machine learning (AIML) can play a significant role in enhancing demand forecasting in business. AIML is a programming language designed for creating chatbots and conversational agents, but its application extends beyond simple interactions. In the context of demand forecasting, AIML can be utilized to analyze historical data, customer interactions, and market trends. By implementing AIML algorithms, businesses can create intelligent models that learn from past demand patterns, customer …
Published in Journal of Computer Technology & Applications · Vol. 15, Issue 1, 2024 · pp. 35–40 Read article
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In Silico Assessment of Demethoxycurcumin: Molecular Docking and Computational Insights into its various therapeutic Potential
Abstract: Natural compounds are increasingly explored for their therapeutic potential in medical research. Here, we focused on demethoxycurcumin (DMC), a polyphenolic bioactive compound extracted from Curcuma longa, commonly found in turmeric. DMC, with a chemical formula of C20H18O5 and a molecular weight of 340 g/mol, possesses two aromatic ring systems, each featuring a β-diketone moiety connected by a seven-carbon chain. This unique structure allows DMC to engage in tautomerism, which is …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 9–15 Read article
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Study of Pros and Cons of Today’s Modern Operating System
Abstract: This research paper delves into the intricate realm of modern computer systems, which serve as the backbone of our daily digital interactions. These systems play a crucial role in powering the devices we rely on, from smartphones and tablets to laptops and desktop computers. By examining the positives and challenges inherent in these systems, this paper aims to shed light on their profound impact on our digital lives. One key …
Published in Journal of Operating Systems Development & Trends · Vol. 11, Issue 1, 2024 · pp. 17–23 Read article
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Navigating the Digital Frontier: An In-depth Analysis of Classroom Digitalization
Abstract: When we talk about the Internet, we think about the likes of social media, or platforms like Google which has an unfathomable archive of information which is available for any and every individual to use up to their own likings. However, there are several challenges and complexities associated with the Internet's impact on social interactions. The issues of online harassment, privacy, and the addictive nature of social media have become …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 1, Issue 2, 2023 · pp. 14–20 Read article
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Real-time Voice-over Translation
Abstract: The real-time voice-over translation project stands as a pioneering endeavor poised to reshape the landscape of cross-cultural communication. In response to the escalating demand for fluid interaction amidst linguistic diversity, this initiative sets out to engineer a transformative solution. Its core objective lies in the seamless mediation of language barriers during real-time exchanges. Through the fusion of cutting-edge speech recognition and machine translation technologies, the project endeavors to fabricate a …
Published in International Journal of Computer Science Languages · Vol. 2, Issue 1, 2024 · pp. 24–32 Read article
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Integration of Taguchi and MCDM Techniques for the Optimization of Experimental Parameters in Electrical Discharge Machining: A Research
Abstract: Electric discharge machining (EDM) represents a non-conventional approach to machining, particularly beneficial for processing hard-to-machine materials or components with high length-to-diameter ratios or intricate shapes. Widely employed across various industries such as automotive, chemical, aerospace, biomedical, and tool and die, EDM offers a unique method for achieving precise shapes and dimensions. Unlike traditional machining methods where form is attained through the interaction of the tool and workpiece, EDM operates without …
Published in Trends in Mechanical Engineering & Technology · Vol. 14, Issue 1, 2024 · pp. 6–14 Read article
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Introduction to Biological Networks and their Contributions to Systems Biology
Abstract: Biological networks provide a conceptual framework to represent and analyze the intricate interconnections among the numerous components that make up living systems. This review paper elucidates the foundational principles of networks and their diverse applications in systems biology, highlighting their crucial role in understanding the inherent complexity of biological processes. Utilizing graph theory, these networks represent entities like genes, proteins, and metabolites as nodes, with their interactions depicted as edges. …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 53–70 Read article
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Precision Medicine for Neurofibromatosis Type 1: Progress and Prospects in Drug Discovery
Abstract: Objective: The development of neurofibromas, café-au-lait spots, and other neurological problems are the hallmarks of neurofibromatosis type 1 (NF1), a hereditary disorder. The dearth of efficacious pharmaceutical therapies underscores the need for novel therapeutic approaches, even in the face of clinical variability. Through very accurate prediction of the binding affinity of possible therapeutic drugs with the target protein, the computational technique known as “molecular docking” has become a potent tool …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 01–15 Read article
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Smart Door Lock System Using IOT
Abstract: The Internet of Things (IoT) represents a revolution in the way we interact with technology and the world around us. It incorporates a network of interconnected devices, sensors, and systems that collect, share, and analyze information to be effective, enhance decision-making, and improve every aspect of our lives. This content aims to provide an indepth look at the evolution, current state and future potential of the Internet of Things. The …
Published in International Journal of Satellite Remote Sensing · Vol. 1, Issue 2, 2023 · pp. 10–13 Read article