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480 articles for “Drug Delivery”
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Recent Advances in Delivering Strategies of Domperidone Challenges and Opportunities
Abstract: Domperidone (DMP), a potent gastroprokinetic and antiemetic drug, exhibits poor aqueous solubility and limited oral bioavailability. Therefore, to develop oral preparations with optimized oral bioavailability, the pharmacokinetic parameters of DMP need to be controlled. The present review aimed to discuss the physicochemical characteristics of DMP causing its unfavorable oral delivery, to explore the viable oral formulation approaches, and to propose some recent formulation approaches that can mitigate the above mentioned …
Published in Trends in Drug Delivery · Vol. 8, Issue 2, 2023 · pp. 13–24 Read article
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Evaluation of Mucoadhesive Polymers for Nasal Delivery of Herbal Bioactives
Abstract: A study assessed mucoadhesive polymers for intranasal herbal bioactive administration with higher residence time and mucosal permeability. Chitosan, Carbopol® 934P, and HPMC K15M were utilized to manufacture mucoadhesive nasal gels with standardized herbal bioactive fractions. Formulations were examined for pH, viscosity, spreadability, drug content, mucoadhesive strength, in-vitro release, ex-vivo penetration, and short-term stability. All formulations demonstrated a suitable pH for nasal usage and uniform drug content (97.48 ± 1.12% to …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1680–1689 Read article
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Polymeric Micelles for Medicinal Plant Solubilization and Delivery of Bioactive Compounds
Abstract: This study involved the design, fabrication, and characterization of polymeric micellar nanocomposites utilizing amphiphilic block copolymers to effectively encapsulate and transport hydrophobic phytoconstituents. The selected bioactive molecule is curcumin, a polyphenol with limited water solubility. A polymeric system known as PEG-PCL was utilized to fabricate core-shell nanostructures by a solvent evaporation-induced self-assembly method. The resulting nanocomposites exhibited homogeneity and colloidal stability, characterized by a zeta potential of −18.7 ± 1.4 …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 208–219 Read article
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Chewable Healthcare: The Rising Impact of Gummy Supplements in Modern Medicine
Abstract: Gummy supplements, a chewable dosage form historically associated with pediatric vitamin products, are increasingly recognized as a versatile platform for delivering a wide range of nutraceutical and pharmaceutical agents. Their consumer appeal lies in their palatability, convenience, and the ability to overcome swallowing difficulties—a significant barrier to adherence in multiple patient populations. Recent advances in formulation science have expanded the potential of gummy supplements beyond basic vitamin delivery to include …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 52–68 Read article
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Formulation and Evaluation of Aqueous Azadirachta indica Phytosome
Abstract: A phytosome is a complex created through the union of a natural compound, typically a plant extract, with a phospholipid. Phospholipids play a crucial role in cell membranes, possessing a structure comprising a hydrophilic (water-attracting) head and hydrophobic (water-repelling) tails. This distinctive structure enables phospholipids to construct lipid bilayers, fundamental elements of cell membranes. Phytosome increases the bioavailability, and absorption of active chemical constituents in the extract with the help …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 1, 2024 · pp. 17–30 Read article
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Nanorobots: The Fight against Cholesterol
Abstract: Cardiovascular disease (CVD) rests leading reason of death globally, with atherosclerosis, the buildup of plaque in arteries, playing a central role. Current treatment strategies, including lifestyle changes and medications, often fall short in completely reversing or preventing the progression of atherosclerosis. This has spurred the exploration of innovative approaches, with nanorobotics emerging as a promising avenue for targeted plaque control and high-density lipoprotein (HDL) enhancement. This article discusses how nanorobots …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 2, 2025 · pp. 23–32 Read article
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Advancements in Nanotechnology and Biosensor Integration for Detection and Treatment of Alice in Wonderland Syndrome
Abstract: Alice in Wonderland Syndrome (AIWS) is an uncommon neurological condition characterized by profound distortions in perception. Individuals with AIWS experience altered body image and spatial awareness, often perceiving objects, surroundings, or even their own body as being unusually large, small, or distorted. The condition presents a unique challenge for both diagnosis and management due to its elusive and varied symptoms. This paper explores how advancements in nanotechnology and biosensor integration …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 26, Issue 3, 2024 · pp. 1–12 Read article
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Revolutionizing Artificial Organs: Next-Generation Membrane Technologies for Precision Medicine and Global Health
Abstract: Membrane technology has emerged as a cornerstone in the advancement of artificial organ systems, offering critical functionalities in selective molecular filtration, tissue scaffolding, and controlled therapeutic delivery. Recent innovations have propelled the field beyond traditional polymeric membranes to include nanostructured, biomimetic, and stimuli-responsive materials, significantly enhancing biocompatibility, selectivity, and durability. The integration of smart technologies, such as AI-driven membrane design, bioelectronic sensors, and personalized fabrication via 3D printing, is ushering …
Published in International Journal of Membranes · Vol. 2, Issue 2, 2025 · pp. 29–39 Read article
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Oral Thin Films of Ondanetron Hcl: Formulation and Performance Evaluation
Abstract: This study had the goal to formulate oral polymeric thin film that would dissolve and disintegrate instantly, while also having high mechanical features. These are the most advanced forms of solid dosage forms. Solvent casting was the technique employed to create oral thin films. These are additionally referred to as buccal films/strip, mouth dissolving films, oral thin films, as well as oral strips of paper. These films are suitable for …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 1–6 Read article
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Formulation Development and Evaluation Technique for Immediate and Modified Release Capsule
Abstract: The development and evaluation of formulations for immediate-release (IR) and modified-release (MR) capsules represent a critical aspect of pharmaceutical dosage form design, offering distinct advantages in terms of drug release profiles and therapeutic outcomes. This study focuses on the formulation strategies, techniques, and evaluation methods used to develop both IR and MR capsules. Immediate-release capsules are designed to disintegrate quickly in the gastrointestinal tract, ensuring rapid drug absorption, while modified-release …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 1–9 Read article
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Formulation, Evaluation and Development of Multipurpose Cream Containing kokum Butter
Abstract: The creation of the multipurpose polyherbal crack-healing cream, which shields the skin from cracks and can also serve as a multifunctional cream to shield the skin from other skin issues. The polyherbal cosmetic formulation can be used to give skin a protective barrier and is safe to use. Over the course of the study, this multipurpose polyherbal cream demonstrated good homogeneity, pH, consistency, spreadability, and lack of phase separation. This …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 78–89 Read article
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Review on Sustained Released Matrix Tablet
Abstract: Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 60–69 Read article
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Chitosan-based Polymer Composites for Antibacterial and Antiviral Drug Applications
Abstract: The natural substance chitosan is made from chitin. It is used a lot in medicine because it is safe for the body, breaks down naturally, and kills germs. To find out how chitosan-based polymer mixes could be used to make drugs that kill germs and viruses, this study looks into them. By reacting with the cell walls of bacteria, chitosan has been shown to kill bacteria and stop viruses from …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 609–620 Read article
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Formulation and Evaluation of Transdermal Patch to Enhance Treatment of Alopecia
Abstract: The improvement of novel topical sedate conveyance frameworks has picked up noteworthy consideration due to their potential in upgrading the helpful viability and persistent compliance whereas minimizing systemic side impacts. This thinks about centers on the definition and assessment of transdermal patches planned to discharge allicin, the essential naturally dynamic compound determined from garlic (Allium sativum) extricate. Allicin is eminent for its wide range of pharmacological properties, counting antimicrobial, anti-inflammatory, …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 20–33 Read article
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Biodegradable Polymer Nanocarriers Composites for Biomedical Applications
Abstract: Smart polymeric nanocarriers, or SPNs, have evolved into a fascinating means of delivering medications especially to cancer cells. By improving the efficacy of chemotherapeutic treatments while lowering their negative effects, they have achieved a significant progress in exact medicine. Made to respond to certain elements in the tumours microenvironment, such as enzymes, temperature, pH, and redox conditions, these nanocarriers this reaction to triggers guarantees the release of the medicine at …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 293–305 Read article
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Biodegradable and Natural Fiber-Reinforced Polymer Composites for Antimicrobial Coatings in Biomedical Applications
Abstract: Since they make medical equipment more biocompatible and practical, biomedical polymers are quite crucial for the advancement of medical technologies. One of the most exciting applications for biomedical polymers is their possible use as protective drug coatings for devices. These coatings aim to limit bacterial binding and biofilm growth, two key causes of illnesses acquired after implantation. Scientists are searching for fresh approaches to combat microorganisms as the issue of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 392–405 Read article
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Evaluation of Polyethylene Glycol (PEG)-Based Polymers for Improving Solubility and Bioavailability of Poorly Soluble Drugs
Abstract: A significant barrier to optimizing oral bioavailability is the inadequate water solubility of numerous pharmaceutical compounds. This study examined whether polymer systems utilizing polyethylene glycol (PEG) may enhance the solubility and bioavailability of a poorly soluble model drug. Multiple PEG polymers with molecular weights between 2,000 and 10,000 Da were utilized to produce PEGylated preparations. The formulations were subsequently evaluated for dissolution efficacy, medication loading capacity, particle size, and solubility …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 489–499 Read article
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Biopolymer-Based 3D Composite Scaffolds for Bone Tissue Engineering: Photothermal-Responsive Systems with Controlled Pt (IV) Prodrug Release
Abstract: Biopolymer-based composite scaffolds have attracted significant attention as multifunctional platforms at the intersection of polymer science, regenerative medicine, and cancer nanotherapy. In this study, a dual-functional scaffold was developed for simultaneous osteosarcoma treatment and bone regeneration using poly (L-lactic acid) (PLLA) reinforced with bioactive glass (BG) and integrated with a glutathione-responsive platinum (IV) prodrug system (PDA@Pt). To improve interfacial adhesion, photothermal conversion efficiency, and tumor-specific activation, the Pt (IV) prodrug …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 351–361 Read article
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Applications of Nano-Chemical Compounds
Abstract: The review study collected good information about nano-chemicals such as nano-polymers and nano-chemicals that are included in the fields of materials sciences and polymers and the connections of these sciences with physics, mechanical engineering, bio-engineering and chemical engineering from multiple branches and sub-specialties within these sciences, all related to the investigation of the properties of matter at this small level. Nanotechnology is a scientific application that produces things by assembling …
Published in Journal of Materials & Metallurgical Engineering · Vol. 11, Issue 3, 2021 · pp. 11–20 Read article
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Development of Biodegradable Stents from Polymeric Composites for Cardiovascular Applications
Abstract: Cardiovascular diseases are still one of the leading health complications in the world, and coronary artery disease remains one of the toughest ones to crack. The introduction of stent implantation in interventional cardiology is a breakthrough concept which helps to restore blood flow and maintain patency of the arteries. On the other hand, long-term results of bare-metal stents and drug-eluting stents indicate the presence of complications, such as in-stent restenosis, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 181–191 Read article