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183 articles for “protein-protein interaction”
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In silico analysis of Abrus precatorius L. as a potential agonist of PPARγ : A novel approach to the treatment of diabetes
Abstract: Diabetes mellitus is a chronic disorder that is characterized by a lack of insulin secretion by the pancreas or a defect in insulin action, or both. If diabetes is not controlled, over time it can cause damage to blood vessels and nerves, leading to life-threatening complications such as, kidney damage, heart disease and vision impairment. It can also weaken the immune system, making patients more prone to infection. Although treatments …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 13–24 Read article
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Development of Biodegradable Poly (Lactic-Co-Glycolic Acid) (PLGA) Nanoparticles for Sustained Release of Insulin
Abstract: This research outlines the creation of biodegradable composite nanoparticles made from poly (lactic-co-glycolic acid) (PLGA) designed for the sustained release of insulin. The emphasis is on the interactions between the polymer and the drug at the interface, along with the dynamics of the release matrix. The in vitro release kinetics, surface morphology, encapsulation efficiency, particle size, and polydispersity of insulin-loaded PLGA nanoparticles were analyzed following their production via a double …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1690–1699 Read article
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article