All articles
36 articles
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Role of PI3K/AKT/mTOR Signaling Pathways in Breast Cancer
Abstract: Abstract: Breast cancer is among the most commonly diagnosed cancers and remains a leading cause of mortality among women globally. Although early detection and interventions aimed at curtailing tumor progression have significantly improved breast cancer survival rates, there is an ongoing demand for more potent systemic therapies to effectively prevent metastasis. A central pathway frequently associated with the growth, survival, and motility of breast cancer cells is the PI3K/AKT/mTOR signaling …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 23–34 Read article
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Assessing Supportive Care Needs Among Breast Cancer Survivors: A Cross-Sectional Study
Abstract: Breast cancer poses a significant global health challenge and ranks among the primary causes of cancer-related morbidity and mortality worldwide. The objective of this study was to evaluate the supportive care needs of survivors of breast cancer and examine how these needs are related to various background factors. To accomplish this, a cross-sectional study was carried out with 116 breast cancer survivors, selected using a convenient sampling method. Data were …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 39–42 Read article
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Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in Philadelphia Chromosome-Positive Leukemias: An Overview of Mechanisms, Clinical Implications, and Management Strategies
Abstract: Tyrosine kinase inhibitors have greatly enhanced the outlook for individuals diagnosed with Philadelphia chromosome-positive leukemias, including chronic myeloid leukemia and acute lymphoblastic leukemia. However, these therapeutic agents are associated with Cardiotoxicities and can manifest as left ventricular dysfunction, which may progress to heart failure, along with electrocardiographic abnormalities, dysrhythmias, hypertension, myocardial ischemia, and thromboembolic events. The unclear frequency of drug-induced cardiovascular complications, coupled with uncertainties regarding their reversibility and long-term …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 18–24 Read article
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Mystic Malignant Melanoma Modalities
Abstract: Melanoma is a highly aggressive form of cancer with four recognized subtypes. In about 90% of cases, melanoma is diagnosed as a primary tumor, without signs of spreading. If caught early, the survival rate is quite high, reaching around 94%. However, for metastatic melanoma, the survival rate drops significantly to about 40%. Diagnosing melanoma can be tricky, as it shares features with benign conditions like seborrheic keratosis, benign moles, blue …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 1–10 Read article
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Cancer Tumor Markers And Its Latest Trends
Abstract: Almost one in six deaths occurs due to abnormal cell division; these cells are termed cancer cells in general. Cancer cells collaborate to multiply and metastasize. Our aim is to awaken awareness in people to understand their bodies and motivate them for early diagnosis,as cancer is the second leading cause of death after cardiovascular disease. The human body is a marvellous creation in nature; in response to cancer, it creates …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 25–38 Read article
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Lung Cancer Detection and Classification Using Deep Learning
Abstract: Lung cancer is a disease that can be effectively treated if detected early. Various technologies, such as magnetic resonance imaging, isotopes, X-rays, and computed tomography scans, are employed for diagnosis. One of the most crucial strategies in combating cancer is early detection, which greatly enhances a patient’s likelihood of survival; this is where artificial intelligence plays a significant role. The approach proposed in this study leverages historical medical data to …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 11–17 Read article
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A Study on the Knowledge of Arterial Blood Gas (ABG) Analysis Among Staff Nurses in a Rural Hospital Setting
Abstract: To evaluate the comprehension of Arterial Blood Gas (ABG) analysis among staff nurses in a designated Rural Hospital, this study aimed to assess their knowledge level and correlate it with specific demographic variables. Utilizing a descriptive approach, the study encompassed all staff nurses within the Rural Hospital, with a sample of 50 individuals meeting the inclusion criteria: completion of either a Diploma in Nursing and Midwifery (GNM) or a Degree …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 2, 2024 · pp. 1–21 Read article
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An Effective Convolutional Neural Network for Identifying Cancer Blood Disorder Cells Using Microscopic Images
Abstract: Blood, bone marrow, and lymphatic systems are all impacted by hematological cancer is known as a cancer blood disorder. Blood malignancies and various blood disorders pose significant health challenges across all age groups. Early disease detection is essential for effective cancer blood disorder treatment and management. If a blood cancer is not identified in time, it may be hazardous. It results in abnormal white blood cell production by the bone …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 2, 2024 · pp. 29–35 Read article
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Breast Cancer: Susceptible Genes and Significant Risk Factors
Abstract: Breast cancer is the most common malignancy affecting women globally. In 2012, around 1.67 million new cases were reported worldwide. With the increase in life expectancy in developed countries, the incidence of breast cancer among older adults has risen significantly. In 2017, an estimated 252,710 new cases of invasive breast cancer were recorded, along with 6,341 cases of breast cancer in situ in the USA. About 24% of all breast …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 2, 2024 · pp. 36–43 Read article
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Cancer Chronicles: An Overview of its Origins, Types, Treatment, and Prevention
Abstract: Cancer is a multifaceted illness characterized by abnormal cell growth and dissemination throughout the body. Its onset usually arises from a mix of genetic mutations and environmental factors. There exist more than 100 distinct forms of cancer, each possessing unique attributes, risk elements, and therapeutic alternatives. Cancer is a pervasive health challenge that knows no boundaries of age, race, or background, continuing to rank among the foremost causes of mortality …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 2, 2024 · pp. 36–42 Read article
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Platelets A Tiny Cell Fragments
Abstract: Platelets are disc-shaped, anucleate cells that are approximately 2-3 μm in diameter. Their primary function is to control hemostasis, or blood clotting, but they also play important roles in angiogenesis (the formation of new blood vessels) and innate immunity (the body's first line of defence against infection). With a diameter of just 2-3 microns, platelets are tiny, disc-shaped cells that lack a nucleus. While their main responsibility is to ensure …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 2, 2024 · pp. 22–28 Read article
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Analyzing Failures and Challenges in Oncology: Integration of Artificial Intelligence in Healthcare
Abstract: The present study focused on investigating the challenges and failures that had been embarked during the deployment of artificial intelligence technologies within the field of oncology in healthcare. Through precise research and statistical analysis, we aimed to elucidate the specific circumstances surrounding each failure, providing insights into the root causes, consequences, and subsequent developments. The present study was aimed to offer a detailed understanding of the challenges faced through artificial …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 42–50 Read article
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Recent Development Technique in Management of Cancer
Abstract: Cancer develops when a change in one's genetic makeup leads to the development of tumour cells. These clusters of malignant cells eventually develop into tumours. Tumours can shed cancerous cells, which can then travel through the lymphatic system or the circulatory system to other organs. In the medical field, this occurrence is referred to as metastasis. Cancer cells proliferate even when they have no instructions to do so. Despite the …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 25–41 Read article
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Efficacy of Combination Therapy with Osimertinib and Afatinib in epidermal growth factor receptor-mutant non-small-cell lung cancer Patients
Abstract: Treatment options for patients with non-small-cell lung cancer who have epidermal growth factor receptor mutations are constrained by the emergence of resistance to epidermal growth factor receptor tyrosine kinase inhibitors. Osimertinib or afatinib alone, when tested in a laboratory model, led to the formation of drug-resistant clones harboring epidermal growth factor receptor secondary mutations. However, combining these drugs prevented the emergence of such mutations. In a Phase II clinical trial, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 13–24 Read article
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An Insight into Childhood Malignancy
Abstract: Childhood cancers represent a significant public health concern, affecting a vulnerable population with unique biological and developmental characteristics. The aim of this article is to describe the main causes and different types of malignancies in childhood. By understanding the contributing factors towards malignancy in childhood one can plan for the preventive measures and early diagnosis and treatment modalities can be adopted. Even though the treatment patterns have improved, people are …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 07–12 Read article
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A Case Report of Advanced Periampullary Carcinoma: Palliative Chemotherapy Following Whipple’s Surgery
Abstract: This case report delves into the complex management of a 60-year-old female patient diagnosed with Stage 4 periampullary carcinoma, encompassing the pancreatic head. Presenting with difficulty in eating, diagnostic investigations, including ERCP, confirmed the diagnosis, leading to Whipple's surgery. Postoperatively, liver metastasis was identified, prompting palliative intervention through stenting and the initiation of a GEMOX chemotherapy regimen. The patient responded favorably to the initial chemotherapy cycle, leading to a planned …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article