All articles
50 articles
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Advancements in Solubility Enhancement Through Liquisolid Compact Technology: A Comprehensive Review
Abstract: The study examines Liquisolid Compact Technology as an innovative approach for improving the bioavailability and solubility of drugs that are poorly soluble in water. Liquisolid systems, comprising solid carriers and liquid drugs, offer advantages such as improved drug release and bioavailability, reduced manufacturing costs, and controlled drug delivery. The technique involves dissolving or suspending the drug in non-volatile solvents, adding carrier materials, super disintegrants, and coating materials, and then compressing …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 25–34 Read article
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Simultaneous Determination And Stability Indicating Method For Telmisartan, Metoprolol Succinate And Cilnidipine In Tablet Dosage Form.
Abstract: There are several medicinal agents available for antihypertensive activity. Telmisartan, metoprolol and cilnidipine are among them. Quantitative and qualitative analysis plays a pivotal role in safeguarding patients. Here, the estimation of these drugs was performed by using the chromatographic technique RP-HPLC. It was conducted with Phosphate buffer (pH 3.5 ± 0.01): Methanol (50:50 v/v) mobile phase. The system was operated at 1 ml/min. Drug volume to the system was 20μl. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 32–38 Read article
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Protective Effects Of Curcumin Against Osteoporosis And Its Molecular Mechanism
Abstract: One of the most prevalent metabolic disorders is osteoporosis (OP), which primarily affects postmenopausal women and the elderly. It is often associated with gradual loss of bone density, ongoing destruction of bone microstructure, and increased risk of osteoporosis. Pharmacotherapy is the primary approach for treating and preventing osteoporosis. However, persistent medication therapy invariably results in drug responses and particular adverse effects. Therefore, scientists continue to search for new monomeric compounds …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 16–23 Read article
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Navigating the Horizon: Current Trends in Elevating Quality Assurance in Clinical Research
Abstract: The landscape of clinical research quality management has evolved significantly in recent years, driven by stringent regulatory frameworks and globalization of trials. This evolution underscores the importance of integrating quality into all aspects of the clinical trial process from design to postresearch activities. Concepts such as Good Clinical Practice (GCP) and Quality by Design (QbD) are central to ensuring the reliability and accuracy of trial data while safeguarding patient safety …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 1–8 Read article
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In Silico Assessment of Demethoxycurcumin: Molecular Docking and Computational Insights into its various therapeutic Potential
Abstract: Natural compounds are increasingly explored for their therapeutic potential in medical research. Here, we focused on demethoxycurcumin (DMC), a polyphenolic bioactive compound extracted from Curcuma longa, commonly found in turmeric. DMC, with a chemical formula of C20H18O5 and a molecular weight of 340 g/mol, possesses two aromatic ring systems, each featuring a β-diketone moiety connected by a seven-carbon chain. This unique structure allows DMC to engage in tautomerism, which is …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 9–15 Read article
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Fast Dissolving Oral Thin Films: A Review
Abstract: Fast-dissolving oral thin films (FDOFs) represent a significant advancement in drug delivery technology, offering advantages over traditional solid dosage forms, especially for patients with swallowing difficulties. FDOFs dissolve rapidly in the mouth, releasing the active ingredient without the need for water or chewing. They have picked up ubiquity due to their comfort, taste veiling capabilities, and progressed persistent compliance. Ideal drugs for FDOFs should possess characteristics such as solubility, stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 24–31 Read article
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A Comparative Study of Atibalāmūla Kvātha and Bhūmyāmalakī Cūrṇa in the Management of Diabetic Sensory Polyneuropathy
Abstract: Bhūmyāmalakī and atibalāmūla is being used in certain hospital since long time with satisfactory results in the patients of diabetic sensory polyneuropathy. An observational study on the use of these plants in diabetic polyneuropathy is published in a peer reviewed journal. Therefore it was selected to evaluate the individual effect of bhūmyāmalakī and atibalāmūla in comparison with the combination of both the drugs in the patients of diabetic sensory polyneuropathy.
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 3, 2023 · pp. 1–11 Read article
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Pharmacognosy and Phytochemical Study of Guduchi
Abstract: Guduchi is most easily and widely available drug with various positive health effect. It is difficult to obtain swarasa of Guduchi due to unavailability of fresh drug. Therefore, this study will focus to find the possibilities of other dosage forms of Guduchi like kwatha and churna, where dry form is being used.
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 2, 2023 · pp. 35–44 Read article
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Distinctive Approaches for Improving the Aqueous Solubility of BCS Class II Drugs
Abstract: The most difficult feature of many novel chemical entities is their solubility behaviour, as 60 percent of new promising products suffer solubility limitations. This is the most common reason for novel medicine compounds failing to reach the market or performing to their full potential. The proportion of the aqueous phase when the solution is in equilibrium with the pure substance in its normal phase is referred to as aqueous solubility. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 3, 2023 · pp. 52–56 Read article
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A Review on Amino Acids
Abstract: Protein is made up of amino acids, which are the building blocks of the molecule. Only 20 amino acids are involved in protein synthesis, even though more than 300 amino acids have been identified. In nature, all twenty amino acids did not appear at the same time. Rather, some of them appeared first, while others were later incorporated into the genetic code. It is vital to include them in one's …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 3, 2023 · pp. 19–27 Read article