STM Journals Peer-reviewed research from Consortium e-Learning Network

Research and Reviews: A Journal of Pharmaceutical Science

Advances in Wound Healing Products and Procedures: A Review

  1. Iswar Hazarika
  2. Anju Das
  3. Vineeth Chandy

Abstract

Victorious wound care involves optimizing patient’s local and systemic conditions in combination with an ideal wound healing environment. Numerous products have been developed till date to influence this wound environment and to provide a pathogen-free, protected, and an area free from moisture for healing to occur in acceleration. Many novel products are being introduced to replace or augment various substrates in the wound healing cascade. With the abundance of available products, the goal is to find the most appropriate modality or combination of modalities to optimize healing. This review looks at the most modern applications of silver in microbial prophylaxis and treatment, including issues involving resistance and side effects, the latest uses of negative pressure wound devices, advanced dressings and skin substitutes, biologic wound products including growth factor applications, and hyperbaric oxygen as an adjunct in wound healing.  Keywords: Wound healing, silver, negative pressure wound devices, hyperbaric oxygen, skin substitutesCite this Article Iswar Hazarika, Anju Das, Vineeth Chandy. Advances in Wound Healing Products and Procedures: A Review. Research & Reviews: A Journal of Pharmaceutical Science. 2016; 7(2): 40–51p.

Keywords

References (66)

  1. Trop M, Novak M, Rodl S, et al. Silver- Coated Dressing Acticoat Caused Raised Liver Enzymes and Argyria-Like Symptoms in Burn Patien t. J Trauma . 2006; 60(3): 648–652p.
  2. Mooney EK, Lippitt C, Friedman J. Silver Dressings (Safety and Efficacy Repo rts). Plast Reconstr Surg. 2006; 117(2): 666– 669p.
  3. Stanford W, Rappole BW, Fox CL. Clinical Experience with Silver Sulfadiazine, a New Topical Ag ent for Control of Pseudomonas Infect ions in Burns. J Trauma. 1969; 9(5): 377–388p. Research & Reviews: A Journal of Pharmaceutical Science Volume 7, Issue 2 ISSN: 2229-7006(online) RRJoPS (2016) 40-51 © STM Journals 2016. All Rights Reserved Page 48
  4. Warriner R, Burrell R. Infection and the Chronic Wound: A F ocus on Silver. Adv Skin Wound Care. 2005; 18: 2–12p.
  5. Atiyeh BS, Costagliola M, Hayek SN, et al. Effect of Silver on Burn Wound Infection Control and Healing: Review of the Literature. Burns. 2007; 33(2): 139– 148p.
  6. Khundkar R, Malic C, Burge T. Use of Acticoat Dressings in Burns: What is the Evidence? Burns. 2010; 36(6): 751–758p.
  7. McHugh GL, Moellering RC, Hopkins CC, et al. Salmonella Typhimurium Resistant to Silver Nitrate, Chloramphenicol, and Ampicillin. Lancet. 1975; 1(7901): 235–240p.
  8. Deshpande LM, Chopade BA. Plasmid mediated Silver Resistance in Acineto Bacter baumannii. Bio Metals. 1994; 7(1): 49–56p.
  9. Hendry AT, Stewart IO. Silver-Resistant Enterobacteriaceae from Hospital Patients. Can J Microbiol. 1979; 25(8): 915–921p.
  10. Haefeli C, Franklin C, Hardy K. Plasmid- Determined Silver Resist ance in Pseudomonas Stutzeri Isolated from a Silver Mine. J Bacteriol . 1984; 158(1): 389–392p.
  11. Gupta A, Matsui K, Lo JF, et al. Molecular Basis for Resistance to Silver Cations in Salmonella . Nat Med. 1999; 5(2): 183–188p.
  12. Yin HQ, Langford R, Burrell RE. Comparative Evaluation of the Antimicrobial Ac tivity of Acticoat Antimicrobial Barrier Dressing . J Burn Care Rehabil. 1999; 20(3): 195–200p.
  13. Wright JB, Lam K, Burrell RE. Wound Management in an Era of Increasing Bacterial Antibiotic Resistance : A Role for Topical Silver Treat ment. Am J Infect Control. 1998; 26(6): 572–577p.
  14. Huang Y, Li X, Liao Z. A Randomized Comparative Tr ial between Acticoat and SD-Ag in the Treatment of Residual Burn Wounds, Including Safety Analysis. Burns. 2007; 33(2): 161–166p.
  15. Fong J, Wood F, Fowler B. A Silver Coated Dressing Reduces the Incidence of Early Burn Wound Cellu litis and Associated Costs of Inpatient Treatment: Comparative Patient Care Au dits. Burns. 2005; 31(5): 562–567p.
  16. Tredget EE, Shankowsky HA, Groeneveld A, et al. A Matched-Pair, Randomized Study Evalua ting the Efficacy and Safety of Acticoat Silver-Coated Dressing for the Treatment of Burn Wounds. J Burn Care Rehabil. 1998; 19(6): 531–537p.
  17. Liedberg H, Lundeberg T. Assessment of Silver-Coated Urinary Catheter Tox icity by Cell Cult ure. Urol Res . 1989; 17(6): 359–360p.
  18. Lam PK, Chan ESY, Ho WS, et al. In vitro Cytotoxicity Testing of a Nanocrystalline Silver Dressing (Acticoat) on Cultured Keratinocytes. Brit J Biomed Sci. 2004; 61(3): 125–127p.
  19. Innes ME, Umraw N, Fish JS, et al. The Use of Silver Coated Dressing s on Donor Site Wounds: A Prospective, Controlled Matched Pair Stu dy. Burns. 2001; 27(6): 621–627p.
  20. Argenta LC, Morykwas MJ. Vacuum- Assisted Closure: A New Method for Wound Co ntrol and Treatment: Clin ical Experience. Ann Plast Surg . 1997; 38(6): 563–577p.
  21. Argenta LC, Morykwas MJ, Marks MW, et al. Vacuum-Assisted Closure: Sta te of Clinic Art. Plast Reconstr Surg . 2006; 117(7): 127S–142Sp.
  22. Venturi ML, Attinger CE, Mesbahi AN, et al. Mechanisms and Clinical Applications of the Vacuum-Assisted Closu re (VAC) Device: A Review. Am J Clin Dermatol . 2005; 6(3): 185–194p.
  23. Quah HM, Maw A, Young T, et al. Vacuum Assisted Closure in the Management of the Open Abdomen : Plastic Surgery International. Report of a Case and Initial Experiences. J Tissue Viability. 2004; 14(2): 59–62p.
  24. Kaplan M. Managing the Open Abdomen. Ostomy/Wound Manag. 2004; 50(1): C2– 8p.
  25. Herscovici D, Sanders RW, Scaduto JM, et al. Vacuum-Assisted Wound Cl osure (VAC Therapy) for the Management of Patients with High-Energy Soft Tissue Injuries. J Orthop Trauma . 2003; 17(10): 683–688p.
  26. Dobke MK, Nguyen D, Trott SA. A Novel Approach to Acute Infecti on of the Glenohumeral Joint Following Rotato r Products and Procedures in Wound Healing Hazarika et al. RRJoPS (2016) 40-51 © STM Journals 2016. All Rights Reserved Page 49 Cuff Repair: A Case Serie s. Wounds. 2005; 17(6): 137–140p.
  27. Heugel JR, Parks KS, Christie SS, et al. Treatment of the Exposed Achilles Tendon Using Negative Pressure Wound Therapy: A Case Report. J Burn Care Rehabil. 2002; 23(3): 167–171p.
  28. Morin RJ, Tomaselli NL. Interactive Dressings and Topical Agents. Clin Plast Surg. 2007; 34(4): 643–658p.
  29. Hansen SL, Voigt DW, Wiebelhaus P, et al. Using Skin Replacement Produ cts to Treat Burns and Wounds. Adv Skin Wound Care. 2001; 14(1): 37–45p.
  30. Pham C, Greenwood J, Cleland H, et al. Bioengineered Skin Substitut es for the Management of Burns: A Systematic Review. Burns. 2007; 33(8): 946–957p.
  31. Noordenbos J, Dor´e C, Hansbrough JF. Safety and Efficacy of TransCyte for the Treatment of Partial-Thickness Burns. J Burn Care Rehabil . 1999; 20(4): 275– 281p.
  32. Demling RH, DeSanti L. Closure of Partial-Thickness Facial Bur ns with a Bioactive Skin Substit ute in the Major Burn Population Decreas es the Cost of Care and Improves Outcome. Wounds. 2002; 14(6): 230–234p.
  33. Hansbrough JF, Mozingo DW, Kealey GP, et al. Clinical Trials of a Biosynthetic Temporary Skin Replacement, Dermagraft-Transitional Covering, Compared with Cryopreserved Human Cadaver Skin for Temporary Coverage of Excised Burn Wounds . J Burn Care Rehabil. 1997; 18(1): 43–51p.
  34. Spielvogel RL. A Histologic Stud y of Dermagraft-TC Inpatients’ Burn Wounds. J Burn Care Rehabil . 1997; 18(1): S16– S18p.
  35. Jones I, Currie L, Martin R. A Guide to Biological Skin Substitutes. Brit J Plastic Surg. 2002; 55(3): 185–193p.
  36. Falanga V, Margolis D, Alvarez O. Rapid Healing of Venous Ulcer s and Lack of Clinical Reject ion with an Allogeneic Cultured Human Skin Equiva lent. Arch Dermatol. 1998; 134(3): 293–300p.
  37. Gottlieb ME. Management of Complex and Pathological Wounds with Integra . The Wound Management Manual . 2004; 226–289p.
  38. Lineen E, Namias N. Biologic Dressing in Burns. J Craniofac Surg . 2008; 19(4): 923–928p.
  39. Jeng JC, Fidler PE, Sokolich JC. Seven Years’ Experience with Integra as a Reconstructive Tool. J Burn Care Res . 2007; 28(1): 120–126p.
  40. Gottlieb ME. Histogenesis Versus Wound Repair: The Anato my of Integra’s Properties. In Proceedings of the Boswick Burn and Wound Meeting , Maui . Feb 2003.
  41. Cianfarani F, Tommasi R, M. Failla CM. Granulocyte/Macrophage Colony - Stimulating Factor Tr eatment of Human Chronic Ulcers Promotes Angiogenesis Associated with de novo Vascular Endothelial Growth Factor Transcr iption in the Ulcer Be d. Br J Dermatol . 2006; 154(1): 34–41p.
  42. Marques da Costa R, Ribeiro Jesus FM, Aniceto C, et al. Randomized, Double- Blind, Placebo -Controlled, Dose -Ranging Study of Granulocyte-Macrophage Colony Stimulating Factor in Patients with Chronic Venous Leg Ulc ers. Wound Repair Regen. 1999; 7(1): 17–25p.
  43. Cruciani M, Lipsky BA, Mengoli C, et al. Are Granulocyte Colony -Stimulating Factors Benef icial in Treating Diabetic Foot Infe ctions? A Meta-Analysis. Diabetes Care. 2005; 28(2): 454–460p.
  44. Bennett SAL, Birnboim HC. Receptor- Mediated and Protein Kinase -Dependent Growth Enhance ment of Primary Human Fibroblasts by Platelet Activating Fac tor. Mol Carcinog. 1997; 20(4): 366–375p.
  45. Steed DL, Webster MW, Ricotta JJ. Clinical Evaluation of Recombinant Human Platelet -Derived Gr owth Factor for the Treatment of Lower Extremity Diabetic Ulcers. J Vasc Surg. 1995; 21(1): 71–81p.
  46. Margolis DJ, Bartus C, Hoffstad O, et al. Effectiveness of Recombinant Human Platelet-Derived Growth Factor for the Treatment of Diabetic Neuropathic Foo t Ulcers. Wound Repair Regen. 2005; 13(6): 531–536p.
  47. Shackelford DP, Fackler E, Hoffman MK, et al. Use of Topical Recombinant Human Platelet-Derived Growth Factor BB in Abdominal Wound Separa tion. Am J Obstetr Gynecol. 2002; 186(4): 701–704p. Research & Reviews: A Journal of Pharmaceutical Science Volume 7, Issue 2 ISSN: 2229-7006(online) RRJoPS (2016) 40-51 © STM Journals 2016. All Rights Reserved Page 50
  48. Hom DB, Manivel JC. Promoting Healing with Recombinant Human Platelet - Derived Growth Fac tor-BB in a Previously Irradiated Problem Wound. Laryngoscope. 2003; 113(9): 1566–1571p.
  49. Hunter S, Langemo DK, Anderson J, et al. Hyperbaric Oxygen Therapy for Chronic Wounds. Adv Skin Wound Care . 2010; 23(3): 116–119p.
  50. Boykin JV. Hyperbaric Oxygen Therapy: A Physio logical Approach to Selected Problem Wound Heal ing. Wounds. 1996; 8(6): 183–198p.
  51. Bauer SM, Bauer RJ, Velazquez OC. Angiogenesis, Vasculogenesis, and Induction of Healing in Chronic Wounds. Vasc Endovascular Surg . 2005; 39(4): 293–306p.
  52. Velazquez OC. Angiogenesis and Vasculogenesis: Inducing the Growth of New Blood V essels and Wound Heali ng by Stimulation of Bone Marrow -Derived Progenitor Cell Mobilization and Homing. J Vascular Surg. 2007; 45(6): 39–47p.
  53. Tepper OM, Galiano RD, Capla JM. Human Endothelial Progenitor C ells from Type II Diabetics Exhi bit Impaired Proliferation, Adhesion, and Incorporation into Vascular Structures. Circulation. 2002; 106(22): 2781–2786p.
  54. Loomans CJM, De Koning EJP, Staal FJT. Endothelial Progenitor Cell Dysfunction: A Novel Concep t in the Pathogenesis of Vascular Complica tions of Type 1 Diabetes. Diabetes. 2004; 53(1): 195– 199p.
  55. Ii M, Takenaka H, Asai J. Endothelial Progenitor Thrombospondin -1 Mediates Diabetes-Induced Dela y in Plastic Surgery International Re- Endothelialization Following Arterial Injury. Circ Res. 2006; 98(5): 697–704p.
  56. Thom SR, Bhopale VM, Velazquez OC, et al. Stem Cell Mobilization by Hyperbaric Oxygen. Am J Physiol . 2006; 290(4): H1378–H1386p.
  57. Goldstein LJ, Gallagher KA, Bauer SM. Endothelial Progenitor Cell Re lease into Circulation is Triggered by Hyperoxia- Induced Increases in Bone Marrow Nitric Oxide. Stem Cells . 2006; 24(10): 2309– 2318p.
  58. Gallagher KA, Goldstein LJ, Thom SR, et al. Hyperbaric Oxygen and Bone Marrow- Derived Endothelial Progenitor Cell s in Diabetic Wound Healing. Vascular. 2006; 14(6): 328–337p.
  59. Jones SR, Carpin KM, Woodward SM. Hyperbaric Oxygen Inhibits Ischemia - Reperfusion-Induced Neutrophil CD18 Polarization by a Nitric Oxide Mechanism. Plast Reconstr Surg . 2010; 126(2): 403– 411p.
  60. Khiabani KT, Bellister SA, Skaggs SS, et al. Reperfusion-Induced Neutrophil CD18 Polarization: Effect of Hyperbaric Oxygen. J Surg Res . 2008; 150(1): 11– 16p.
  61. Gabriel A, Porrino ML, Stephenson LL, et al. Effect of L -Arginine on Leukocyte Adhesion in Ischemiare Perfusion Injury. Plast Reconstr Surg . 2004; 113(6): 1698– 1702p.
  62. Zamboni WA, Wong HP, Stephenson LL, et al. Evaluation of Hyperbaric Oxygen for Diabetic Woun ds: A Prospective Study. Undersea Hyperb Med . 1997; 24(3): 175–179p.
  63. Kranke P, Bennett M, Roeckl -Wiedmann I, et al. Hyperbaric Oxygen Thera py for Chronic Wounds. Cochrane Database Syst Rev. 2004; 2. Article CD004123.
  64. Londahl M, Katzman P, Nilsson A, et al. Hyperbaric Oxygen Therapy Facilitates Healing of Chronic Foot Ulcers in Patients with Diabetes. Diabetes Care . 2010; 33(5): 998–1003p.
  65. Abidia A, Laden G, Kuhan G. The Role of Hyperbaric Oxygen Therapy in Ischaemic Diabetic Lower Extremity Ulcers : A Double-Blind Randomized-Controlled Trial. Eur J Vasc Endovas Surg . 2003; 25(6): 513–518p.
  66. Bedi MK. Herbal Therapy in Dermatology. Arch Dermatol . 2002; 138: 232–242p. AUTHOR BIBLIOGRAPHY Iswar Hazarika Iswar Hazarika is an Assistant Professor at “T John College of Pharmacy, Bangalore”. Iswar keeps keen interest on teaching and research. He is an M. Products and Procedures in Wound Healing Hazarika et al. RRJoPS (2016) 40-51 © STM Journals 2016. All Rights Reserved Page 51 Pharm in Pharmacology from “The Oxford College of Pharmacy, Bangalore” and B. Pharm from “Regional Institute of Paramedical and nursing sciences, Aizawl” and always a rank holder in the universities. He completed his entire schooling from “Jawahar Navodaya Vidyalaya, Dhemaji”. Cite this Article Iswar Hazarika, Anju Das, Vineeth Chandy. Advances in Wound Healing Products and Procedures: A Review. Research & Reviews: A Journal of Pharmaceutical Science . 2016; 7(2): 40–51p.

You might also find these relevant

Read more of it

Subscribe to one journal or build your own list of several. One invoice, one payment, access for a full year.

Subscribe to journals →

Publish your article

Peer-reviewed journals across every subject, with open access options. Send your manuscript to the right editor today.

Publish with us → Calculate your APC
Support