Immunomodulatory Activity of Alcoholic Extract of Onosma bracteatum in Mice

Gajendra Pratap Choudhary

Abstract

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} The primary objective behind present study was to investigate the immunomodulatory potential of the ethanolic extract of Onosma bracteatum on cellular and humoral immunity. The ethanolic extract of ariel parts of Onosma bracteatum, was administered orally at a dose of 100mg/kg in mice, which dose-dependently potentiated the delayed-type hypersensitivity reaction. It significantly enhanced the production of circulating antibody titre in mice with response to SRBCs (Sheep red blood cells).

Abstract

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