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Research and Reviews: A Journal of Pharmacology Original Research

A Prospective Observational Study of Prescription and Quality of Life: Gastroesophageal Reflux Disease in Territory Care Hospital

  1. Nicky Kumar Jaiswal School of Pharmacy, Desh Bhagat University, Mandi, Gobindgarh
  2. Priyanka Singh Department of Dental Sciences, Adesh Institute of Dental Sciences and Research, Adesh University, Bathinda
  3. Kirti Department of Pharmaceutical Sciences, Amritsar Group of Colleges, Amritsar
  4. Vishal Kumar School of Pharmacy, Desh Bhagat University, Mandi, Gobindgarh

Abstract

Aims and objective: The main aim of the study is to know the quality of life in GERD patients and the management of GERD with the help of prescription patterns and patient counseling.

Methodology: After receiving approval from Departmental Research Committee AIPBS with the reference no AIPBS/2021/4586/11 on dated 30 September 2021 and also approved from the Ethics Committee of Biomedical and Health Research, Adesh University with the reference no AU/EC/PH/2K22/87, the study was performed at Adesh Hospital, Bathinda. The study was a prospective observational study with a total number of 100 GERD patients and a study duration of 6 months. The data were recorded in the self-structured questionnaire.

Result: A total number of 100 GERD patients were studied along with their prescription pattern and quality of life. It was determined that particular classes of drugs were prescribed to the patients with their dose details, and age, health condition, gender, and smoking are the factors that affect the quality of life. Gastroesophageal reflux disease is a chronic condition characterized by the backflow of stomach acid or bile into the oesophagus, causing irritation of the lining. GERD is a condition characterized by the occurrence of uncomfortable symptoms and discomfort caused by the backflow of stomach contents. GERD, or gastroesophageal reflux disease, is a common condition affecting the upper gastrointestinal tract. It is estimated that one-third of the population suffers from GERD, with around 10 million cases occurring annually in India. In Western countries, a weekly occurrence of GERD symptoms is reported by 10% to 20% of the population. The diagnosis of GERD is established by evaluating the patient's clinical history and anamnesis, which involves identifying the specific symptoms, their duration, intensity, frequency, triggers, and factors that provide relief. It is also important to assess the progression of symptoms over time and their impact on the patient’s quality of life. Commonly reported symptoms include heartburn and acid regurgitation.

Keywords

References (23)

  1. Wang YK, Hsu WH, Wang SSW, Lu CY, Kuo FC, Su YC, et al. Current Pharmacological Management of Gastroesophageal Reflux Disease. Gastroenterology Research and Practice. 2013;2013:1-12. doi:10.1155/2013/983653
  2. Badillo R. Diagnosis and treatment of gastroesophageal reflux disease. World Journal of Gastrointestinal Pharmacology and Therapeutics. 2014;5(3):105. doi:10.4292/wjgpt.v5.i3.105
  3. Henry MACDA. Diagnosis and management of gastroesophageal reflux disease. ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo). 2014;27(3):210-215. doi:10.1590/s0102-67202014000300013
  4. Tutuian R, Castell DO. Management of Gastroesophageal Reflux Disease. The American Journal of the Medical Sciences. 2003;326(5):309-318. doi:10.1097/00000441-200311000-00007
  5. Al-Zahrani S, Mohamed M, Mohammed A, Al-Harbi N, Al-Qatari B, Alatwi S, et al. Gastroesophageal reflux disease and heartburn among the general population of Saudi Arabia. International Journal of Medicine in Developing Countries. 2019:933-940. doi:10.24911/ijmdc.51-1567426442
  6. Peery AF, Dellon ES, Lund J, Crockett SD, McGowan CE, Bulsiewicz WJ, et al. Burden of Gastrointestinal Disease in the United States: 2012 Update. Gastroenterology. 2012;143(5):1179-1187.e3. doi:10.1053/j.gastro.2012.08.002
  7. Butt AK, Hashemy I. Risk factors and prescription patterns of gastroesophageal reflux disease: HEAL study in Pakistan. J Pak Med Assoc. 2014;64(7):751–757.
  8. Abrahão-Junior LJ, Lemme EMO. Manifestações extra-esofágicas da DRGE. J Bras Med. 2012; 100(5):17–21.
  9. Gyawali CP, Fass R. Management of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):302-318. doi:10.1053/j.gastro.2017.07.049
  10. Heidelbaugh JJ, Nostrant TT, Kim C, Van Harrison R. Management of gastroesophageal reflux disease. Am Fam Physician. 2003;68(7):1311–1319.
  11. El–Serag HB. Time Trends of Gastroesophageal Reflux Disease: A Systematic Review. Clinical Gastroenterology and Hepatology. 2007;5(1):17-26. doi:10.1016/j.cgh.2006.09.016
  12. Katzka DA, Kahrilas PJ. Advances in the diagnosis and management of gastroesophageal reflux disease. BMJ. 2020:m3786. doi:10.1136/bmj.m3786
  13. Velanovich V. Comparison of generic (SF-36) vs. disease-specific (GERD-HRQL) quality-of-life scales for gastroesophageal reflux disease. Journal of Gastrointestinal Surgery. 1998;2(2):141-145. doi:10.1016/s1091-255x(98)80004-8
  14. El-Serag HB, Sweet S, Winchester CC, Dent J. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2013;63(6):871-880. doi:10.1136/gutjnl-2012-304269
  15. Andrade FJC, et al. Qualidade de vida do paciente submetido à cirurgia videolaparoscópica para tratamento para doença do refluxo gastroesofagico. ABCD Arq Bras Cir Dig. 2012;25(3):154–160.
  16. Chua YC, Aziz Q. Perception of gastro-oesophageal reflux. Best Practice & Research Clinical Gastroenterology. 2010;24(6):883-891. doi:10.1016/j.bpg.2010.10.003
  17. Esubi JU, Olojede SO, Lawal SK, Medubi LJ, Adekoya AJ, Dauda FF, Olusegun AP, Osinubi AA. Comparative studies on safety of glimepiride and glipizide on renal microarchitecture and oxidative stress markers of pregnant streptozotocin-induced diabetic wistar rats. J Pharm Pharmacol Res. 2019;3(1):3–18.
  18. Arivan R, Deepanjali S. Prevalence and risk factors of gastro-esophageal reflux disease among undergraduate medical students from a southern Indian medical school: a cross-sectional study. BMC Research Notes. 2018;11(1). doi:10.1186/s13104-018-3569-1
  19. Alrashed A, Aljammaz K, Pathan A, Mandili A, Almatrafi S, Almotire M, et al. Prevalence and risk factors of gastroesophageal reflux disease among Shaqra University students, Saudi Arabia. Journal of Family Medicine and Primary Care. 2019;8(2):462. doi:10.4103/jfmpc.jfmpc_443_18
  20. Eusebi LH, Ratnakumaran R, Yuan Y, Solaymani-Dodaran M, Bazzoli F, Ford AC. Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis. Gut. 2018;67(3):430–440. doi:10.1136/gutjnl-2016- 313589.
  21. Singh S, Sharma AN, Murad MH, Buttar NS, El–Serag HB, Katzka DA, et al. Central Adiposity Is Associated With Increased Risk of Esophageal Inflammation, Metaplasia, and Adenocarcinoma: A Systematic Review and Meta-analysis. Clinical Gastroenterology and Hepatology. 2013;11(11):1399-1412.e7. doi:10.1016/j.cgh.2013.05.009
  22. Spantideas N, Drosou E, Bougea A, Assimakopoulos D. Gastroesophageal reflux disease symptoms in the Greek general population: prevalence and risk factors. Clinical and Experimental Gastroenterology. 2016:143. doi:10.2147/ceg.s103485
  23. Awadalla NJ. Personal, academic and stress correlates of gastroesophageal reflux disease among college students in southwestern Saudi Arabia: A cross-section study. Annals of Medicine and Surgery. 2019;47:61-65. doi:10.1016/j.amsu.2019.10.009
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