The Era of Pharmacology Toward Pharmacogenomics

Rajavarman kittu; Anuja Mishra

Abstract

In both Modern Laboratory medicine as well medical science both the Pharmacogenomics is fast, emerging, outcome driven approach which is generally termed as precision medicine. Understanding the importance of gene-drug association and clinical implementation, effect of drug choices over the clinical subjects are kind of need of hour as it is proof of concept for evidence driven therapeutic approach. Also, in research prospective the genome wide association studies (GWAS) which helps the researches to corelate genotype data captured from the population with drug-response phenotypes gives the scopes to discover the drug efficacy and adverse drug reactions. Also, the concepts of pharmacokinetics or pharmacodynamics are having strong impacts based on the coding regions of the genes in polymorphism resolution which affects the disparate treatment outcomes. This review article focused on highlighting the nomenclatures used in pharmacogenomics, well characterised classifications, definitions provided but serval consortium of pharmacogenomics, understanding the standards of gene-drug corelation, drug efficacy, drug relations in order to improve the clinical implication and outcome of patience.

Abstract

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