STM Journals Peer-reviewed research from Consortium e-Learning Network

Research and Reviews: A Journal of Pharmacology

A Review: An Introduction to Atypical Lipoma and their Brief Natural Treatment

  1. Brijesh Dasvani
  2. Avani Khristi

Abstract

Atypical lipomatous are rare tumours arising from soft tissues of the body and most commonly affect adults. Lipomas are benign tumors composed of mature fat cells. These slow growing tumors, almost always benign, are generally in the form of round, motile, non-painful masses with a characteristic soft and soggy feel. Lipomas are seen in the hypodermic area of skin. Lipomas can be associated with syndromes such as multiple hereditary lipomatosis, colorless adipose, Gardner's syndrome and Madelung's disease. Keyword: Rare tumor, fat cells, soft tissues, surgical removal, herbal therapy Cite this ArticleBrijesh Dasvani, Avani Khristi. A Review: An Introduction to Atypical Lipoma and their Brief Natural Treatment. Research & Reviews: A Journal of Pharmacology. 2019; 9(2): 30–36p.

Keywords

References (85)

  1. Evans HL, Soule EH, Winkelmann RK. Atypical lipoma, atypical intramuscular lipoma, and well -differentiated retroperitoneal liposarcoma: a reappraisal of 30 cases formerly classified as well - A Review: An Introduction to Atypical Lipoma and their Brief Natural Treatment Dasvani and Khristi RRJoP (2019) 30-36 © STM Journals 2019. All Rights Reserved Page 33 differentiated liposarcoma. Cancer 1979; 43:574–584.
  2. Lucas DR, Nascimento AG, Sanjay BK, Rock MG. Well -differentiated liposarcoma: The Mayo Clinic experience with 58 cases. Am J Clin Pathol 1994; 102:677–683.
  3. Dei Tos AP. Liposarcoma: new entities and evolving concepts. Ann Diagn Pathol 2000; 4:252–266.
  4. Matsumoto K, Hukuda S, Ishizawa M, Chano T, Okabe H. MRI findings in intramuscular lipomas. Skeletal Radiol 1999; 28:145–152.
  5. Allen PW, Strungs I, MacCormac LB. Atypical subcutaneous fatty tumors: a review of 37 referred cases. Pathology 1998; 30:123–135.
  6. Stewart MG, Schwartz MR, Alford BR. Atypical and malignant lipomatous lesions of the head and neck. Arch Otolaryngol Head Neck Surg 1994; 120:1151–1155.
  7. Laurino L, Furlanetto A, Orvieto E, Del Tos AP. Well -differentiated liposarcoma (atypical lipomatous tumors ). Arch Otolaryngol Head Neck Surg 2001; 18:258–262.
  8. Kindblom LG, Angervall L, Fassina AS. Atypical lipoma. Acta Pathol Microbiol Immunol Scand [A] 1982; 90:27–36.
  9. Forus A, Larramendy ML, Meza -Zepeda LA, et al. Dedifferentiation of a well - differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22 -q24 associated with metastases. Cancer Genet Cytogenet 2001; 125:100–111.
  10. Ohguri T, Aoki T, Hisaoka M, et al. Differential diagnosis of benign peripheral lipoma from well -differentiated liposarcoma on MR imaging: is comparison of margins and internal characteristics useful? AJR 2003; 180:1689–1694.
  11. Matsumoto K, Takada M, Okabe H, Ishizawa M. Foci of signal intensities different from fat in well -differentiated liposarcoma and lipoma: correlation between MR and histological findings. Clin Imaging 2000; 24:38–43.
  12. Yang YJ, Damron TA, Cohen H, Hojnowski L. Distinction of well - differentiated liposarcoma from lipoma in two patients with multiple well - differentiated fatty masses. Skeletal Radiol 2001; 30:584–589.
  13. Meis JM, Enzinger FM. Chondroid lipoma: a unique tumor simulating liposarcoma and myxoid chondrosarcoma. Am J Surg Pathol 1993; 17:1103–1112.
  14. Gomez-Ortega JM, Rodilla IG, Basco Lopez de Lerma JM. Chondroid lipoma: a newly described lesion that may be mistaken for malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 81:586–589.
  15. Lakshmiah SR, Scott KW, Whear NM, Monoghan A. Chondroid lipoma: a rare but diagnostically important lesion. Int J Oral Maxillofac Surg 2000; 29:445–446.
  16. Logan PM, Janzen DL, O'Connell JX, Munk PL, Connell DG. Chondroid lipoma: MRI appearances with clinical and histologic correlation. Skeletal Radiol 1996; 25:592–595.
  17. Furlong MA, Fanburg -Smith JC, Miettinen M. The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am J Surg Pathol 2001; 25:809–814.
  18. Rozental TD, Khoury LD, Donthineni-Rao R, Lackman RD. Atypical lipomat ous masses of the extremities: outcome of surgical treatment. Clin Orthop 2002; 398:203–211.
  19. Weiss SW, Rao VK. Well -differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites: a follow -up study of 92 cases with analysis of the incidence of “dedifferentiation.” Am J Surg Pathol 1992; 16:1051–1058.
  20. Galant J, Marti -Bonmati L, Saez F, Soler R, Alcala -Santaella R, Navarro M. The value of fat suppressed T2 or STIR sequences in distinguishing lipom a from well-differentiated liposarcoma. Eur Radiol 2003; 13:337–343.
  21. Hosono M, Kobayashi H, Fujimoto R, et al. Septum -like structures in lipoma and liposarcoma: MR imaging and pathologic Research & Reviews: A Journal of Pharmacology Volume 9, Issue 2 ISSN: 2230-9861 (Online), ISSN: 2349-1299 (Print) RRJoP (2019) 30-36 © STM Journals 2019. All Rights Reserved Page 34 correlation. Skeletal Radiol 1997; 26:150–
  22. 22. Keskin G, Ustundag E, Ercin C. Multiple infiltrating lipomas of the tongue . J Laryngol Otol2002; 116:395-7.
  23. Jelinek JS, Kransdorf MJ, Shmookler BM, Aboulafia AJ, Malawer MM. Liposarcoma of the extremities: MR and CT findings in the histologic subtypes. Radiology 1993; 186:455–459.
  24. Kransdorf MJ, Bancroft LW, Peterson JJ, Murphey MD, Foster WC, Temple HT. Imaging of fatty tumors: distinction of lipoma and well -differentiated liposarcoma. Radiology 2002; 224:99 –
  25. 25. Ezirmik N, Yildiz K. Deep intramuscular lipoma in thigh . Med J Bakirkoy 2011; 7:167-9.
  26. Collela G, Lanza A, Rossiello L, Rossiello R. Infiltrating lipoma of the tongue . Oral Oncology Extra2004; 40:33-5.
  27. Einarsdottir H, Soderlund V, Larson O, Jenner G, Bauer HC. MR imaging of lipoma and liposarcoma. Acta Radiol 1999; 40:64–68.
  28. Einarsdottir H, Soderlund V, Larsson O, Mandahl N, Bauer HC. 110 subfascial lipomatous tumors: MR and CT findings versus histopathological diagnosis and cytogenetic analysis. Acta Radiol 1999; 40:603–609.
  29. Akbulut M, Aksoy A, Bir F. Intramuscular lipoma of the tongue: a case report and review of the literature . Aegean Pathol 2005; 2:146-9.
  30. Lipoma: Causes, Symptoms, Diagnosis, Treatments and Prevention Available from: https://www.medlife.com/web/lipoma- causes-symptoms-diagnosis-treatments- prevention/access on [April 2019].
  31. Billing V, Mertens F, Domanski HA, Rydholm A. Deep-seated ordinary and atypical lipomas: histopathology, cytogenetics, clinical feat ures, and outcome in 215 tumours of the extremity and trunk wall. J Bone Joint Surg Br 2008; 90:929-33.
  32. Bassett MD, Schuetze SM, Disteche C, et al. Deep-seated, well differentiated lipomatous tumors of the chest wall and extremities. The role of cytogeneti cs in classification and prognostication . Cancer2005; 103:409-16.
  33. Su CH, Hung JK, Chang IL. Surgical treatment of intramuscular, infiltrating lipoma. Int Surg2011; 96:56-9.
  34. Lee Y, Jung J, Baek G, Chung M. Intramuscular Lipoma in the Thenar or Hypothenar Muscles. Hand Surgery 2004; 9:49-54.
  35. Matsumoto K, Hukuda S, Ishizawa M, Chano T, Okabe H. MRI findings in intramuscular lipomas . Skeletal Radiol 1999; 28:145-52.
  36. Elbardouni A, Kharmaz M, Salah Berrada MS, et al. Well-circumscribed deep-seated lipomas of the upper extremity. A report of 13 cases . Othop Traumatol Surg Res 2011; 97:152-8.
  37. Bjerreagaard P, Hagen K, Daugaard S, Kofoed H. Intramuscular lipoma of the lower limb. Long -term follow -up afte r local resection. J Bone Joint Surg Br 1989; 71:812-5.
  38. Kindblom LG, Angervall L, Stener B, et al. Intermuscular and intramuscular lipomas and hibernomas: a clinical, roentgenologic, histologic, and prognostic study of 46 cases . Cancer 1974; 33:754-
  39. 39. Kransdorf MJ, Moser RP, Jr, Meis JM, Meyer CA. Fat-containing soft -tissue masses of the extremities . Radiographics 1991; 11:81-106.
  40. Lahrach K, Kadi K, Mezzani A, et al. An unusual case of an intramuscular lipoma of the biceps brachii . Pan African Med J 2013; 15:40.
  41. Pant R, Poh ACC, Hwang SG. An unusual case of an intramuscular breast mass . Ann Acad Med Singapore 2005; 34:275-6.
  42. Balabram D, Cabral CCdSR, Filho OdPR, Barros CPd. Intramuscular lipoma of the subscapularis muscle . Sao Paulo Med J 2014; 132:65-7.
  43. Oyama N, Oyama N, Hiroshi K, et al. Left ventricular asynchrony caused by an intramuscular lipoma: computed tomographic and magnetic resonance detection. Circulation 2003; 107: e200-1. A Review: An Introduction to Atypical Lipoma and their Brief Natural Treatment Dasvani and Khristi RRJoP (2019) 30-36 © STM Journals 2019. All Rights Reserved Page 35
  44. Takamori S., Miwa K., Hayashi A, Shirouzu K. Intramuscular lipoma in the chest wall. Eur J Cardiothorac Surg 2004; 26:1038.
  45. Ramos Pascua L, Alonso León A, Santos Sánchez JA, Ferrández Portal L. Intramuscular lipoma of the deltoid mimicking a sarcoma. A case reports. Chir Organi Mov 2001; 86:153-7.
  46. Warner JJ, Madsen N, Gerber C. Intramuscular lipoma of the deltoid causing shoulder pain: report of two cases. Clin Orthop 1990; 253:110-2.
  47. Egea Martinez JM, Mena JF. Lipoma of the supraspinatus muscle causing impingement syndrome a case report . J Shoulder Elbow Surg 2009; 18:3-5.
  48. Ferrari L, Haynes P, Mack J, DiFelice GS. Intramuscular lipoma of the supraspinatus causing impingement syndrome . Orthopedics 2009; 32:601.
  49. D’Alfonso TM, Shin SJ. Intramuscular lipoma arising within the pectoralis major muscle presenting as a radiographically detected breast mass . Arch Pathol Lab Med 2011; 135:1061-3.
  50. Gopal U, Patel MH, Wadhwa MK. Intramuscular lipoma of the pectoralis major muscle . J Postgraduate Med 2002; 48:330.
  51. Gutknecht DR. Painful intramuscular lipoma of the thigh . South Med J 2004; 97:1121-2.
  52. Harrington AC, Adnot J, Chesser RS. Infiltrating lipomas of the upper extremities. J Dermatol Surg Oncol 1990; 16:834-7.
  53. Fletcher CD, Martin -Bates E. Intramuscular and intermuscular lipoma: neglected diagnoses. Histopathology 1988; 12:275-87.
  54. Chernev I. Intramuscular lipoma: infiltrating vs. well -circumscribed variant. Pan Afr Med J2014; 17:170.
  55. Lee JH, Do HD, Lee JC. Well- circumscribed type of intramuscular lipoma in the chest wall . J Cardiothorac Surg 2013; 8:181.
  56. Morris AD, Jane MJ, Ritchie D, Helliwell T. Diffuse intramuscular lipomatosis of a lower limb. Sarcoma 1998; 2:53-6.
  57. Matsumoto K, Hukuda S, Ishizawa M, et al. Liposarcoma associated with multiple intramuscular lipomas. A case reports . Clin Orthop Relat Res 2000; 373:202-7.
  58. Usta U, Tü rkmen E, Mizrak B, et al. Spindle cell lipoma in an intramuscular lipoma. Pathol Int2004; 54:734-9.
  59. Atilla S, Eilenberg SS, Brown JJ. Hibernoma: MRI appearance of a rare tumor. Magn Reson Imaging 1995; 13:335–337.
  60. Peer S, Kuhberger R, Dessl A, Judmaier W. MR imaging findings in hibernoma. Skeletal Radiol 1997; 26:507.
  61. Cook MA, Stern M, de Silva RD. MRI of a hibernoma. J Comput Assist Tomogr 1996; 20:333–335.
  62. Geis JR, Russ PD, Adcock KA. Computed tomography of a symptomatic infarcted thoracic lipoma. J C omput Tomogr 1988; 12:54–56.
  63. Andac N, Baltacioglu F, Cimsit NC, Tuney D, Aktan O. Fat necrosis mimicking liposarcoma in a patient with pelvic lipomatosis: CT findings. Clin Imaging 2003; 27:109–111.
  64. Evans H. Liposarcomas and atypical lipomatous tumors: a s tudy of 66 cases followed for a minimum of 10 years. Surg Pathol 1988; 1:41–54.
  65. Shane McTighe and Ivan Chernev . Intramuscular Lipoma: A Review of the LiteratureOrthop Rev (Pavia). 2014 Oct 27; 6(4): 5618.
  66. Spano JP, Taillibert S, Khayat D, Terrier P. Hibernoma: an uncommon tumor as a differential diagnosis of liposarcoma of the thigh. Anticancer Res 2000; 20:4803– 4804.
  67. Anderson SE, Schwab C, Stauffer E, Banic A, Steinbach LS. Hibernoma: imaging characteristics of a rare benign soft tissue tumor. Skeletal Radiol 2001; 30:590–595.
  68. Murphey MD, Carroll JF, Flemming DJ, et al. From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics 2004; 24:1433-66.
  69. Ramos-Pascua LR, Guerra -Álvarez OA, Sánchez-Herráez S , et al. Intramuscular lipomas: Large and deep benign lumps not to be underestimated. Review of a series of 51 cases . Rev Esp Cir Ortop Traumatol2013; 57:391-7. Research & Reviews: A Journal of Pharmacology Volume 9, Issue 2 ISSN: 2230-9861 (Online), ISSN: 2349-1299 (Print) RRJoP (2019) 30-36 © STM Journals 2019. All Rights Reserved Page 36
  70. Regan JM, Bickel WH, Broders AC. Infiltrating benign lipomas of the extremities. West J Surg1946; 54:87-93.
  71. Austin RM, Mack GR, Townsend CM, Lack EE. Infiltrating (intramuscular) lipomas and angiolipomas: a clinicopathologic study of six cases . Arch Surg 1980; 115:281-4.
  72. Dutton J, Wright J. Intramuscular lipoma of the superior oblique muscle . Orbit 2006; 25:227-33.
  73. Dionne GP, Seemayer TA. Infiltrating lipomas and angiolipomas revisited . Cancer 1974; 33:732-8.
  74. Greenberg SD, Isensee C, Gonzalez - Angulo A, Wallace SA. Infiltrating lipomas of the thigh . Am J Clin Pathol 1963; 39:66-72.
  75. Wurlitzer F, Bedrossian C, Ayaia A, et al. Problems of diagnosing and treating infiltrating lipomas . Am Surg 1973; 39:240-3.
  76. Goldman AB, DiCarlo EF, Marcove RC. Case report 774. Coincidental parosteal lipoma with osseous excrescence and intramuscular lipoma . Skeletal Ra diol 1993; 22:138-45.
  77. Laliotis A, Bree E, Vasilaki S, et al. Co- existence of intramuscular spindle cell lipoma with an intramuscular ordinary lipoma: report of a case . Pol J Pathol 2013; 64:224-7.
  78. Momin TA, Deyrup AT, Grist WJ, et al. Laryngeal squamous cell carcinoma metastatic to a flank intramuscular lipoma. Am Surg 2008; 74:447-8.
  79. Nishida J, Morita T, Ogose A, et al. Imaging characteristics of deep -seated lipomatous tumors: intramuscular lipoma, intermuscular lipoma, and lipoma -like liposarcoma. J Orthop Sci 2007; 12:533-41.
  80. Garavaglia J, Gnepp D. Intramuscular (infiltrating) lipoma of the tongue. Oral Surg Oral Med Oral Pathol 1987; 63:348-50.
  81. Colella G, Biondi P, Caltabiano R, et al. Giant intramuscular lipoma of the tongue: a case report and literature review. Cases J 2009; 2:7906.
  82. Pichierri A, Marotta N, Raco A, Delfini R. Intramuscular infiltrating lipoma of the longus colli muscle: a very rare cause of neck structures compression . Cent Eur Neurosurg 2010; 71:157-9.
  83. Charles NC, Palu RN. Intramuscular lipoma of the eyelid . Ophthalmic Surg Lasers 2000; 31:340-1.
  84. Allen B, Rader C, Babigian A. Giant lipomas of the upper extremity . Can J Plast Surg 2007; 15:141-4.
  85. Kapetanakis S, Papathanasiou J, Dermon A, et al. Unusual intramuscular lipoma of the deltoid muscle . Folia Medica 2010; 52:68-71. Cite this Article Brijesh Dasvani, Avani Khristi. A Review: An Introduction to Atypical Lipoma and their Brief Natural Treatment . Research & Reviews: A Journal of Pharmacology . 2019; 9(2): 30–36p.
Support