Recurrent Pregnancy Loss and Thrombophilia: An insight

Mudasir Maqbool; Irfat Ara; Mehrukh Zehravi; Imran Gani

Abstract

By definition, thrombophilia refers to acquired and/or hereditary diseases that predispose people to venous and arterial thromboembolic events. The most common cause of death on the planet is thrombosis. Myocardial infarction and stroke are major causes of morbidity and mortality in the vascular system. The deep veins of the lower extremity are the most usually involved in venous thromboembolic events, which can lead to pulmonary emboli. Thromboembolism is the major cause of antepartum and postpartum maternal mortality, as pregnancy is a hypercoagulable state. Recurrent Pregnancy Loss (RPL) is a major public health issue, with about 15-20 percent of all clinically diagnosed pregnancies ending in a miscarriage. RPL affects about 1% to 2% of women and is defined as three successive pregnancy losses before 20 weeks. Patients' lives are severely impacted by recurrent pregnancy loss. Each miscarriage leaves you feeling bereft and bewildered. The link between thrombophilia and recurrent pregnancy loss (RPL) has been shown beyond a shadow of a doubt. The physiologic changes of pregnancy, which create a relative hypercoagulable condition, as well as physical alterations that contribute to greater stasis, and the impact of both inherited and acquired thrombophilias, all play a role in the development of thrombosis in pregnancy. The importance of each of these factors in the development of thrombophilia is discussed in this review, as well as the evidence regarding the influence of pregnancy-related thrombosis on pregnancy outcomes.