In silico Bioprospection and Identification of Propitious Herbal Mitigators Against Highly Virulent Pathogenic Strains of Bacteria Like Vancomycin Resistant Enterococci

Raman Chawla; Pallavi Thakur; Raghav Nagpal; Rajeev Goel; Shyam Sunder Grover; Alka Narula; Rajesh Arora; Rakesh Kumar Sharma

doi:10.37591/rrjohs.v4i1.707

Abstract

Vancomycin resistance genes have been isolated from various strains of Enterococci, owing to the high rate of recombination and vast potential of disseminating resistant genes between Enterococcal strains. Various virulent factors contribute towards the dissemination of infections caused by such Multi-Drug Resistant (MDR) strains, ultimately leading to a devastating state of environmental contamination and cross infection. Minimizing the prevalence of these strains by multiple control efforts therefore is of paramount importance. Thus effective strategic measures are needed for mitigation of Vancomycin resistant strains. The new therapeutic regimen should be efficacious at lower doses with significantly reduced side effects and should trim down treatment duration. The current bioprospective study aims to investigate the probable potential of various herbals against Vancomycin Resistant Enterococcal infections dependent on bioactivity parameters using matrix based modeling and herbal informatics. The outcomes of the lead identification need verification for confirming the bactericidal potential against Vancomycin Resistant Enterococci at both in vitro and in vivo level. Keywords: antibacterial agents, herbal mitigation, ethno pharmacology, drug resistance, molecular dockingCite this Article:Thakur P, Chawla R, Nagpal R, et al,In silico Bioprospection and Identification of Propitious Herbal Mitigators Against Highly Virulent Pathogenic Strains of Bacteria Like Vancomycin Resistant. Enterococci Research and Reviews: Journal of Herbal Science. 2015; 5(1): 1–14p.