Research and Reviews: A Journal of Toxicology
Volume 8, Issue 3 (2018)
Published
Table of contents
-
Acute Toxicity, Morphological Changes and Behavioral Responses Induced by Sodium Perfluorooctanoate in Indian Major Carp Labeo rohita (Ham.)
Abstract: Sodium perfluorooctanoate (NaPFO) is an anthropogenic ubiquitous environmental pollutant mainly used in textile, paper and ink industries, for specialized usage as emulsifiers, firefighting foam, lubricants etc. It finds entry into aquatic ecosystem through effluents from these industries. Static renewal bioassay test was conducted to determine 96 h LC50 of NaPFO on Indian major carp, Labeo rohita. The behavioral and morphological alterations in fingerlings were observed critically during the whole experiment …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 3, 2018 · pp. 1–8 Read article
-
Ameliorating Effect of Vitamin C on Acid Orange 7 Induced Oxidative Stress in the Gill of the Fish, Anabas testudineus (Bloch, 1792)
Abstract: Acid orange 7, an azo dye, was exposed to Anabas testudineus at a sublethal concentration (0.27 g/l) for 24, 72 and 96 h in order to evaluate the antioxidant status in the gill tissue. In addition, vitamin C at 0.55 g/l was exposed for 7 days after the dye exposure. Acid orange 7 decreased the body weight of fish, whereas mucous deposition increased significantly as the first line of defensive …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 3, 2018 · pp. 15–27 Read article
-
PHD-2 Activation to Stabilize HIF-1α and FASN in Mammary Gland Cancer
Abstract: Activation of prolyl hydroxylase-2 (PHD2) has emerged as an attractive target to counteract tumor hypoxia and thereby uncontrolled cellular proliferation. We utilized an integrated strategy to identify new PHD2 activators using series of in silico tools and in vitro methods. The in silico screening helped to identify 4-ethyl-3-(4-methoxyphenyl)-2,2-dimethyl-2H-chromen-7-yl acetate (BBAP-3), [4-(7-acetyloxy-4-ethyl-2,2-dimethylchromen-3-yl)phenyl]acetate (BBAP-4), 3-(4-methoxyphenyl)-2,2,4-trimethyl-2H-chromen-7-yl acetate (BBAP-5) as an activator, who are structurally similar to KRH102140 (a known activator of PHD2). All …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 3, 2018 · pp. 28–33 Read article
-
Speech and Language Profile in a Client Diagnosed with Drug-Induced Parkinsonism
Abstract: Drug-induced Parkinsonism (DIP) is the second-most common cause of Parkinsonism. Researchers differentiate Parkinsonism and DIP through several potent factors. Patients diagnosed with DIP exhibit characteristics such as tremors, rigidity, akinesia, postural instability etc similar to Parkinsonism but the basic difference is that the symptoms would resolve or turn better after the cessation of the drug leading to the deficits. This study deals with a 60-year-old lady diagnosed with Parkinsonism after …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 3, 2018 · pp. 34–36 Read article
-
A Research Project on Identification and Reporting of Adverse Drug Reactions in General Medicine Ward of an ESI Hospital
Abstract: Aim: The study aims at identifying and reporting the adverse drug reactions (ADRs) in general medicine ward of an ESI hospital, Bangalore, Karnataka, India. Objective: Prescription study, analysis and prevention of medication-related problems (ADRs), identifying and minimizing medication-related problems, improving patient safety initiatives, improving the patient health-related outcomes, reducing work burden of physicians, and providing better therapy to large number of patients. Methodology: Study Design: It was a prospective and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 3, 2018 · pp. 9–14 Read article