Research & Reviews: A Journal of Drug Design & Discovery
Volume 8, Issue 1 (2023)
Published
Table of contents
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Evaluation of the Effect of Sodium Lauryl Sulphate on Curcumin Microspheres
Abstract: Purpose: To evaluate the effect of the surfactant - sodium lauryl sulphate (SLS) on curcumin microspheres.Methods: Curcumin microspheres were prepared by solvent evaporation method by varying the ratios of the polymers like Eudragit S 100, ethyl cellulose (EC). Ethanol/dichloromethane blend was used as solvent in a ratio of 1:1 to prepare the drug-polymer dispersion and the surfactant SLS was used to prepare the aqueous phase. The prepared microspheres were evaluated …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 1, 2023 · pp. 1–11 Read article
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A Review on Targeted Protein Degradation and Its Novel Therapeutic Approaches
Abstract: A new concept of drug development is drug-induced degradation of a target protein. Protein degradation is one of the cell's methods for permanently inactivating proteins. The Ubiquitin-Proteasome System (UPS) and autophagy are two main intracellular protein degradation pathways in eukaryotes. Autophagy has been shown to be induced by inhibiting proteasomal activities, suggesting a coordinated and complementary relationship between these two mechanisms. However, little is known about autophagy's function in UPS …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 1, 2023 · pp. 12–23 Read article
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Development of Validated Stability Indicating RP-HPLC Method for Amisulpride Injection
Abstract: Objective of the present work is to develop and validate a simple, cost effective, sensitive and fast RPHPLC method for the analysis of Amisulpride injection. A Waters HPLC system with Octacysilane 150 mm × 4.6 mm column is employed for the analysis using pH 4.5 phosphate buffer solution, acetonitrile and methanol in the ratio of (75:20:5 v/v) as mobile phase. Signal from Amisulpride is detected at 280 nm by UV …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 1, 2023 · pp. 24–40 Read article
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Concept of Arthritis Diseases
Abstract: Arthritis is a chronic disease caused by the inflammation of the joints. It can affect one or more than one joints. It affects more women than men and also the older people above 60 years of age. Its symptoms include reduction of the weight. Muscle weakness, its inability to use the hands or walk, difficulty in moving the joints, improper sleep, inflammation, malaise and tiredness, unbending nature, muscle pain etc. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 1, 2023 · pp. 41–45 Read article
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Therapeutic Effects of Metformin on Cancer: A Possible Option in Cancer Chemotherapy
Abstract: Metformin is being used for an elongated period of an antidiabetic medicine for type 2 diabetes. It is used moreover as a monotherapy or in mixture with additional antidiabetic medications. The drug derived into importance in diabetes and other circumstances with cardiovascular risk after the landmark study of 1995 by the United Kingdom Prospective Diabetes Study which highlighted its reputation. The usage of metformin, the usually given drug for type …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 1, 2023 · pp. 46–68 Read article