Research & Reviews: A Journal of Bioinformatics
Volume 2, Issue 3 (2015)
Published
Table of contents
-
3D Structure Determination and Analysis of ER-Lipid Raft Associated 1 Protein from Homo sapiens
Abstract: ER-lipid raft associated 1(ERIN 1) is a protein coding gene encoded by ERLIN 1 gene. Autosomal Recessive HSP associated with ERLIN 1 .Structure prediction of ERLIN 1 was done using a server based approach. I-Tasser an online structure prediction tool was used for tertiary structure prediction of the protein. The best model was selected by using model evaluation tools like PROSA, ERRAT and Ramachnadran plot. Keywords: ERLIN 1, Hereditary Spastic …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 3, 2015 · pp. 1–7 Read article
-
Molecular Interaction and Simulation Studies of Inhibitors for Endothelin-1 Receptors
Abstract: High altitude cerebral edema (HACE) is a life threatening severe form of acute mountain sickness (AMS) which causes headache, unbalanced gait, behavioral changes, and altered mental status. It also carries features like hallucinations or coma, as well as a variety of neurological deficits. Prevention of edema fluid formation with minimal side effects remains to be discovered. Endothelin-1 receptors were found to be involved in the pathogenesis of HACE. Due to …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 3, 2015 · pp. 15–26 Read article
-
Phylogenetics of Anopheles and Aedes Mosquito Species in View of Ordant-Binding Protein Motifs of Drosophila
Abstract: Various species of mosquitoes were identified, based on the DNA sequences and subjected to multiple sequence alignment considering the motifs as hallmarks and in turn evolved a phylogenetic cladogram. Keywords: Sequence, phylogenetics, motif, anopheles and aedesCite this ArticleDamodaran Divya, Rani Vimala Grace, Sekar T, et al. Phylogenetics of anopheles and Aedes mosquito species in view of ordant-binding protein motifs of drosophila. Research & Reviews: A Journal of Bioinformatics. 2015; 2(3): …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 3, 2015 · pp. 27–37 Read article
-
Methodologies for in silico and in vitro Test of Biphenylalanine Compounds as Potential HIV-1 gp120 Attachment Inhibitors
Abstract: We postulate that biphenylalanine and its derivatives are propitious candidates to inhibit the binding of HIV-gp120 to CD4 T-cell. Many biphenylalanine derivatives are synthesized chemically and also prevailing in nature. We have proposed atom- and bond-based 2D TOMOCOMD-CARDD approach to identify the best derivative. Moreover, according to our proposition, the principal law simulated from in silico interaction of gp120 with CD4 can be tested by ELISA in vitro. Furthermore, the …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 3, 2015 · pp. 38–42 Read article
-
Analysis of Transcription Factor Binding Sites of Co-expressed Genes in Colorectal Tumor by Microarray Data Analysis
Abstract: The utilization of global gene expression profiling to find genes with similar expression patterns is rapidly becoming an extensive approach for understanding the complex cellular processes and disease mechanism. The polygenic nature of colorectal tumor, one of the most deadly cancers worldwide is believed to be caused not only by defects in single gene, but rather by the variation in multiple genes and their complex interactions. However, the regulatory mechanisms …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 3, 2015 · pp. 8–14 Read article