Research & Reviews: A Journal of Bioinformatics
Volume 2, Issue 2 (2015)
Published
Table of contents
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In- silico Design of Novel Inhibitors for Benzimidazole Receptor against Cryptosporidium parvum
Abstract: Cryptosporidium parvum is an obligate, intracellular, protozoan parasite belonging to the phylum Apicomplexa. Cryptosporidium parvum is increasingly being recognized as an important pathogen causing diarrhea in children, with the highest associated morbidity and mortality, especially among children in developing countries. The highest prevalence of cryptosporidiosis has been documented in children aged 6–12 months. 3D QSAR studies were carried out on benzimidazole derivatives to identify new improved possible inhibitors. kNN-MFA methodology …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 2, 2015 · pp. 1–10 Read article
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In- silico Design of Novel Inhibitors for 5-HT2A Receptor to Recuperate Schizophrenia
Abstract: Schizophrenia is a mental disorder characterized by positive symptoms such as disorganized speech, delusions and hallucinations and negative symptoms such as deficits of attention, affective flattening and social withdrawal in nature. There are several receptor involve in schizophrenia, one of these 5-HT2A receptor i.e. serotonin receptor. The serotonin receptor 5-HT2A has been involved in several neurological conditions and potent 5-HT2A inhibitors have therapeutic effects that use for the treatment of …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 2, 2015 · pp. 11–17 Read article
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Computational Approach in Characterization and Structural Perspective of HPSE2 Gene
Abstract: HPSE2 gene is a gene encoded by heparanase2 enzyme in humans. The gene is found to be associated with urofacial syndrome in humans. The gene is found to be located at Chromosome 10:100.22–101 Mb in human and Chromosome 19:42.79–43.39 Mb in mouse. The current work is done to annotate the gene HPSE2 both functionally as well as sequentially. It includes analysis of the mutation at various sites in the sequences …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 2, 2015 · pp. 18–24 Read article
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Deciphering Neuroinformatics in the Gene Profiling of Mental Retardation using the Tool Geneious Pro and Cytoscape Software
Abstract: Mental retardation (MR) is defined as an overall intelligence quotient lower than 70, associated with functional deficit in adaptive behavior, such as daily-living skills, social skills and communication. Genetic abnormalities frequently give rise to a mental retardation phenotype. The prevalence of mental disability in India was found to be 2.3%. The prevalence was higher among females (3.1%) than among males (1.5%) with a higher finding among the elderly age group …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 2, 2015 · pp. 25–48 Read article
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Evaluation of Penalized Estimation Methods for Big Data Analysis
Abstract: In this paper we described the sparse Laplacian shrinkage (SLS) method which is a penalized method for variable selection and estimation in big data analysis that uses a combination of the minimax concave penalty (MCP) and Laplacian quadratic as the penalty. The SLS uses the MCP to promote sparsity and Laplacian quadratic penalty to encourage smoothness among coefficients associated with the correlated predictors. An important advantage of the MCP over …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 2, Issue 2, 2015 · pp. 49–55 Read article