Research & Reviews: A Journal of Bioinformatics
Volume 1, Issue 2 (2014)
Published
Table of contents
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Pharmacophore Mapping of Dengue Virus Inhibitors of Natural Origin Using Phase and Self Organizing Neural Networks
Abstract: Dengue virus (DENV) infection is an important arthropod-born viral infection infecting about 2.5 billion people worldwide. To date there are no effective vaccine or antiviral treatment for dengue. Dengue patients are usually supportively treated until they recover without any specific treatment measures. Plants and plant’s derived compounds remain an important source for the discovery and the development of new antiviral drugs because of their expected low side effects and their …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 1, Issue 2, 2014 · pp. 1–18 Read article
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Comparative Genomics of Heat Shock Protein in Pathogenic Bacteria
Abstract: Genome comparison has recently become a common research topic in computer science. The development of computer-assisted mathematics (using products such as Mathematica or Matlab) has helped engineers, mathematicians, and computer scientists to start operating in this domain, and a public collection of case studies and demonstrations is growing, ranging from whole genome comparisons to gene expression analysis. This has increased the introduction of different ideas, including concepts from systems and …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 1, Issue 2, 2014 · pp. 19–34 Read article
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Novel Activity of NrnA Homolog Signifies Engineering at Cellular Level
Abstract: Exonuclease homolog protein cloned, expressed, purified and found to have multiple exonuclease activities. This study highlights the importance of cellular engineering at protein level, where one protein can do multiple functions under different conditions. Keywords: exonuclease, homolog, NrnA, DNA replication, RecJ
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 1, Issue 2, 2014 · pp. 35–37 Read article
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Structural Studies of Alternatively Sliced Transcript Isoforms in Context of Esophageal Cancer
Abstract: Microarray one of the high throughput technologies is used to measure the gene expression, which serves as the primary source for different types of analysis. The results of these experiments are stored in several repositories/databases of which many are made publically available. GEO-Gene Expression Omnibus is one among them. Alternative splicing is a regulated process whose deregulation influences cancer. In the present work, the expression array data sets of esophageal …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 1, Issue 2, 2014 · pp. 38–45 Read article