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Journal of Modern Chemistry & Chemical Technology

Hydrotropes as effective reaction Media for the Synthesis of Chlorothiazide

  1. MANOHAR V LOKHANDE
  2. Jagannath Kadam
  3. Ajay Patil
  4. Vijay Gangan
  5. Vijay Bhawe

Abstract

The paper describes the synthesis of Chlorothiazide. It is a thiazide diuretic (water pill). It decreases theamount of fluid in the body by increasing the amount of salt and water lost in the urine. It is also used tolower the blood pressure as antihypertensive and to decrease edema (swelling). The synthesis ofChlorothiazide was carried out using four different hydrotropes, the effect of hydrotropes on yield, rateconstant and activation energy at various temperatures and concentrations were studied.

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