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International Journal of Advance in Molecular Engineering Review Article

Flavonoids: An Answer to Chronic Diseases

  1. Mousumi Karmakar Department of Dietetics and Applied Nutrition, Amity Institute of Applied Science, Amity University
  2. Bandita Datta Department of Chemistry, Amity Institute of Applied Science, Amity University

Abstract

It has been shown that inflammation is closely associated with the onset or exacerbation of quite a few non-communicable human diseases. Several chronic diseases, such as cancer, diabetes, cardiovascular dysfunction and central nervous system damage are also developed following tissue injury produced by the high fragments of low-grade inflammation surrounding a compromised tissue or organ due to its acquired genomic changes. Current therapies for many of these diseases are associated with undesirable, and at times more severe side effects than the actual condition leaving little choice but to seek cheaper options that would be less toxic; this has thus prompted a need for safe treatments. Flavonoids and their compounds have been used in traditional medicine wrongly before ethnomedicines, also for a wide variety of human diseases with use continuing to this day. The aim of this review is to showcase the role of flavonoids which help in reducing inflammation in several chronic illnesses, including diabetes, cancer, heart disease, and neuroinflammation.

Keywords

References (11)

  1. Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017;9(6):7204-7218. doi:10.18632/oncotarget.23208
  2. Ginwala R, Bhavsar R, Chigbu DGI, Jain P, Khan ZK. Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin. Antioxidants. 2019;8(2):35. doi:10.3390/antiox8020035
  3. Cory H, Passarelli S, Szeto J, Tamez M, Mattei J. The Role of Polyphenols in Human Health and Food Systems: A Mini-Review. Frontiers in Nutrition. 2018;5. doi:10.3389/fnut.2018.00087
  4. Soares R, Azevedo I, Sawatzky DA, Rossi AG. Apigenin: Is It a Pro- or Anti-Inflammatory Agent? The American Journal of Pathology. 2006;168(5):1762-1763. doi:10.2353/ajpath.2006.060087
  5. Ullah A, Munir S, Badshah SL, Khan N, Ghani L, Poulson BG, et al. Important Flavonoids and Their Role as a Therapeutic Agent. Molecules. 2020;25(22):5243. doi:10.3390/molecules25225243
  6. Ginwala R, Bhavsar R, Chigbu DGI, Jain P, Khan ZK. Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin. Antioxidants. 2019;8(2):35. doi:10.3390/antiox8020035
  7. Kopustinskiene DM, Jakstas V, Savickas A, Bernatoniene J. Flavonoids as Anticancer Agents. Nutrients. 2020;12(2):457. doi:10.3390/nu12020457
  8. Gandhi GR, Vasconcelos ABS, Wu DT, Li HB, Antony PJ, Li H, et al. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies. Nutrients. 2020;12(10):2907. doi:10.3390/nu12102907
  9. Vezza T, Rodríguez-Nogales A, Algieri F, Utrilla M, Rodriguez-Cabezas M, Galvez J. Flavonoids in Inflammatory Bowel Disease: A Review. Nutrients. 2016;8(4):211. doi:10.3390/nu8040211
  10. Ciumărnean L, Milaciu MV, Runcan O, Vesa ȘC, Răchișan AL, Negrean V, et al. The Effects of Flavonoids in Cardiovascular Diseases. Molecules. 2020;25(18):4320. doi:10.3390/molecules25184320
  11. Thilakarathna S, Rupasinghe H. Flavonoid Bioavailability and Attempts for Bioavailability Enhancement. Nutrients. 2013;5(9):3367-3387. doi:10.3390/nu5093367