2 publications

• Published Subscription 17 May 2022

  Design and Evaluation of Itraconazole Niosomes

  By Panner Selvam R, Jaidul Islam, Vineeth Chandy

  Abstract: The present study was undertaken with an aim to fabricate and characterize and evaluate niosomes of Itraconazole, where the drug is released in a sustained manner for a period of 12 hours. Itraconazole is Class-2 drug having low solubility and have short half-life between 3–4 hours. Due to high first pass metabolism, the drug is rapidly excreted from the body indicating the need of sustained release delivery. To overcome these …

  Published in Trends in Drug Delivery · Vol. 9, Issue 1, 2022 · pp. 62–68 Read article →

• Published Subscription 1 Jun 2019

  Design and Evaluation of Promethazine Hydrochloride Rapimelts

  By R. Panner Selvam, M. P. Gowrav, Vineeth Chandy

  Abstract: Objective: In the present study, efforts were taken to develop rapimelts of promethazine HCl—an antiemetic agent with an objective to achieve rapid disintegration, and further improve thebioavailability of drug.Methods:Rapimelts were prepared by direct compression methodusing superdisintegrants such as crospovidone (cp), croscarmellose sodium (ccs), sodiumstarch glycolate (ssg). The prepared formulations were evaluated for precompressionparameters such as bulk density, tapped density, Carr’s compressibility, Hausner ratio andangle of repose. The prepared batches of …

  Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 1, 2019 · pp. 11–19 Read article →