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Impact of Amiloride-Hydrochlorthiazide Diuretic Against the Pathway of Uric Acid – VLDL and Peroxynitrite in Essential HypertensionBy Ansam Naji Al-Hasani, Omeed Jaleel Daloe
Abstract: Thiazides induce metabolic derangement in terms of hyperlipidemia, glucose intolerance, hyperuricemia and electrolytes imbalance. Co-amiloride-hydrochlorthiazide therapy favorably corrects the hypokalemia that is induced by thiazides alone. This study was aimed to identify the interactions between serum uric acid, very-low-density-lipoprotein (VLDL) and peroxynitrite in essential hypertensive patients using amiloride-hydrochlorthiazide as antihypertensive therapy. A total number of fifty patients (12 males and 38 females) with a history of hypertension were admitted in …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 3, 2015 · pp. 6–11 Read article →