Subacidic 0.5% NaF-HF gel

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• Published Subscription Original Research 26 Feb 2026

  Caries-Preventive Effects of Self-Applied Subacidic 0.5% NaF-HF Gel via Toothbrushing in 7–8-Year-Old Schoolchildren: A Randomized Controlled Clinical Trial

  By Ki-Ho Rim, Chol-Jun Hwang, So Yon Kim, Chol Ho Kim, Byong-So Ri, Sun-Yong Choe, Jin-Hyok Kim

  Abstract: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years Objective: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years. Methods: This 1-year, multi-arm, double-blind, placebo-controlled, parallel-group randomized study evaluated the caries-preventive efficacy of self-applied 0.5% NaF-HF gel among primary schoolchildren. A total of 1200 …

  Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 1, 2026 · pp. 14–19 Read article →