Short-Chain Fatty Acids (SCFAs)

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• Published Subscription Review Article 25 Mar 2026

  Gut Microbial Metabolites in Inflammatory, Metabolic, and Neurologic Disorders.

  By Atul Khajuria *1,, Ashish Kumar 2,, Prabhdeep Singh, Mahesh Gaba,

  Abstract: The human gut microbiota transforms dietary and hostderived substrates into a diverse array of metabolites—including shortchain fatty acids (SCFAs), hydrogen sulfide (H₂S), bile acid derivatives, indoles, trimethylamine Noxide (TMAO), branchedchain amino acid (BCAA) derivatives, and lipopolysaccharide (LPS)—that act as key signaling mediators along epithelial, immune, endocrine, and neural axes. These metabolites regulate barrier integrity, energy homeostasis, inflammation, and gut–brain communication and are increasingly implicated in the pathogenesis of inflammatory bowel …

  Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 58–64 Read article →