oral controlled drug delivery systems
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Formulation Development and Evaluation of Furosemide Loaded Solid Lipid Microparticles
Abstract: Furosemide is a loop diuretic because of having very low half-life, low oral bioavailability, degraded in gastric juice; it was chosen to formulate as the solid lipid microparticle (SLMs) to overcome above. In this study, an attempt was made to improve the oral bioavailability of furosemide by preparing SLMs using stearic acid (SA) and cetostearyl alcohol (CsA) as lipid polymers by hot homogenization method at different drug: polymer ratios (1:5, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 6–18 Read article