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• Published Subscription 22 May 2021

  Synthesis of Novel Series of Coumarin Derivatives

  By Khalid M Darwish, Hussniya A Al-difar, Al Khansaa El-hawat, M. G. Elarfi, T. M. Awin, Haneen Al- difar

  Abstract: In a synthetic method similar to Knoevenagel reaction, 3-acetyl coumarin was prepared in the same way through a cyclization condensation reaction betweensalicylaldehyde and ethyl acetoacetate under basic condition using piperidine. Hence, 3-acetyl coumarin as a starting material was reacted with bromine in ether using a Lewis acid as a reactioncatalyst to produce the corresponding α–bromoaceyl cromen-2-one derivative. In application ofHantzsch synthesis, the reaction of α–bromoaceyl cromen-2-one with thioacetamide in ether …

  Published in Journal of Modern Chemistry & Chemical Technology · Vol. 12, Issue 1, 2021 · pp. 1–8 Read article →