Extended-spectrum beta-lactamases (ESBLs)

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• Published Subscription Review Article 28 Feb 2025

  Extended-spectrum beta-lactamases (ESBLs) and Metallo-beta-lactamases (MBLs): A Review

  By Arun Singha, Bharti Minhas, Naveen Minhas

  Abstract: Gram-negative bacteria produce extended-spectrum beta-lactamases (ESBLs) and metallo-beta-lactamases (MBLs), enzymes that play a crucial role in antibiotic resistance. These enzymes enable the bacteria to withstand a wide array of beta-lactam antibiotics, including penicillins, cephalosporins, and carbapenems. The production of these enzymes, particularly by organisms, such as Escherichia coli and Klebsiella pneumoniae, complicates treatment options for severe infections, leading to increased morbidity and mortality in clinical settings. ESBLs are primarily responsible …

  Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 2, 2025 · pp. 8–19 Read article →