Cabazitaxel

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• Published Subscription 8 Oct 2018

  Neuropathic Potential of Cabazitaxel Comparative to Paclitaxel and Ameliorative Effect of Capsaicin

  By S Pal, A Shukla, P Bigoniya

  Abstract: Paclitaxel and cabazitaxel both are the cytotoxic anticancer drugs having microtubule damaging property. The study aims at comparative neuropathic potential evaluation of cabazitaxel against paclitaxel and to assess the efficacy level of intraperitoneally applied capsaicin isolated from Capsicum annuum seed against both paclitaxel and cabazitaxel-induced neuropathy. Neuropathy was evaluated of heat hyperalgesia, cold allodynia, tactile mechanical hyperalgesia and extent of motor incoordination and motor impairment development on mice. Alternate day …

  Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 5, Issue 2, 2018 · pp. 25–38 Read article →